Glycemic control and antioxidant potential of distinct fractions of camelus dromedaries fresh milk in streptozocin induced diabetic rats.


Journal

Pakistan journal of pharmaceutical sciences
ISSN: 1011-601X
Titre abrégé: Pak J Pharm Sci
Pays: Pakistan
ID NLM: 9426356

Informations de publication

Date de publication:
Jul 2022
Historique:
entrez: 26 8 2022
pubmed: 27 8 2022
medline: 30 8 2022
Statut: ppublish

Résumé

To analyze the antiglycemic effects and to evaluate the anti-oxidant levels in pre and post-camel milk fractions treated albino diabetic rats, sixty male Swiss albino rats weighing 30-40gm aged 2 to 3 months were randomly divided into six groups, A, B, C, D, E & F, each comprised of 10 animals. as Group A: Normal control, Group B: Streptozocin induced Diabetic group while Groups C, D, E & F were diabetic groups treated with various fractions of camel milk. Noteworthy alteration in blood glucose and antioxidant activity was observed between disease control (group B) and all the treated groups with a percentage decrease of about 25%, 12.98%, 11.57% and 10.17% in blood sugar in groups C, D, E and F respectively. Changes in total antioxidant capacity were significant with the rise of 92.30%, 30.76%, 46.15% and 38.46% respectively in groups C, D, E and F. Percentage difference in superoxide dismutase between group B and Group C of 85% was highest as compared to 45.90 %, 52.45% and 39.34% for groups D, E and F. Group C also showed a significantly higher increase in serum copper, zinc and Vitamin C. It is inferred that Camel milk has significant antiglycemic and antioxidant potential and may prove good complementary therapeutics for diabetes.

Identifiants

pubmed: 36008903

Substances chimiques

Antioxidants 0
Blood Glucose 0
Streptozocin 5W494URQ81

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1067-1076

Auteurs

Rizwan Ashraf (R)

University College of Medicine and Dentistry, The University of Lahore, Lahore, Pakistan.

Muhammad Sarwar (M)

Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan.

Noor Kamil (N)

Salim Habib University, Karachi, Pakistan.

Absar Qureshi (A)

College of Pharmacy, King Khalid University, Abha, KSA.

Shahid Waheed (S)

University College of Medicine and Dentistry, The University of Lahore, Lahore, Pakistan.

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Classifications MeSH