New Insights into the Molecular Interplay between Human Herpesviruses and Alzheimer's Disease-A Narrative Review.
Alzheimer’s disease viral hypothesis
amyloid beta (Aβ)
human herpesviruses
neuroinflammation
tau protein
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
30 Jul 2022
30 Jul 2022
Historique:
received:
01
07
2022
revised:
24
07
2022
accepted:
28
07
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
27
8
2022
Statut:
epublish
Résumé
Human herpesviruses (HHVs) have been implicated as possible risk factors in Alzheimer's disease (AD) pathogenesis. Persistent lifelong HHVs infections may directly or indirectly contribute to the generation of AD hallmarks: amyloid beta (Aβ) plaques, neurofibrillary tangles composed of hyperphosphorylated tau proteins, and synaptic loss. The present review focuses on summarizing current knowledge on the molecular mechanistic links between HHVs and AD that include processes involved in Aβ accumulation, tau protein hyperphosphorylation, autophagy, oxidative stress, and neuroinflammation. A PubMed search was performed to collect all the available research data regarding the above mentioned mechanistic links between HHVs and AD pathology. The vast majority of research articles referred to the different pathways exploited by Herpes Simplex Virus 1 that could lead to AD pathology, while a few studies highlighted the emerging role of HHV 6, cytomegalovirus, and Epstein-Barr Virus. The elucidation of such potential links may guide the development of novel diagnostics and therapeutics to counter this devastating neurological disorder that until now remains incurable.
Identifiants
pubmed: 36009073
pii: brainsci12081010
doi: 10.3390/brainsci12081010
pmc: PMC9406069
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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