One-Year Changes in Urinary Microbial Phenolic Metabolites and the Risk of Type 2 Diabetes-A Case-Control Study.
Mediterranean diet
PREDIMED study
bioactive compounds
cardiovascular
liquid chromatography
mass spectrometry
phytochemicals
urinary microbial phenolic metabolites
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
08 Aug 2022
08 Aug 2022
Historique:
received:
20
07
2022
revised:
02
08
2022
accepted:
02
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
27
8
2022
Statut:
epublish
Résumé
The intake of polyphenols has been associated with a risk reduction of type 2 diabetes. Nevertheless, to the best of our knowledge, the molecules that might be metabolically active after ingestion are only starting to be investigated regarding this metabolic disease. To investigate the association between one-year changes in urinary microbial phenolic metabolites (MPM) and the incidence of type 2 diabetes, we performed a case-control study using data and samples of the PREDIMED trial including 46 incident type 2 diabetes cases of 172 randomly selected participants. Eight urinary MPMs were quantified in urine by liquid chromatography coupled to mass spectrometry and used to assess their associations with type 2 diabetes risk by multivariable logistic regression models. Compared to participants in the lowest tertile of one-year changes in hydroxybenzoic acid glucuronide, those in the highest tertile had a significantly lowered probability of developing type 2 diabetes (OR [95% CI], 0.39 [0.23−0.64]; p < 0.001 for trend). However, when additionally adjusting for fasting plasma glucose, the statistical significance was lost. Changes in the dietary pattern can increase the concentrations of this compound, derived from many (poly)phenol-rich foods, and might be changing the gut microbial population as well, promoting the production of the metabolite.
Identifiants
pubmed: 36009259
pii: antiox11081540
doi: 10.3390/antiox11081540
pmc: PMC9405292
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Government of Catalonia
ID : 2017SGR196
Organisme : Ministerio de Ciencia, Innovación y Universidades
ID : AEI/FEDER 10.13039/501100011033, UE
Organisme : Ministerio de Ciencia, Innovación y Universidades
ID : [AGL2016-75329-R] PID2020-114022RB-I00
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