Understanding the Mechanism of Action of Melatonin, Which Induces ROS Production in Cancer Cells.
apoptosis
cancer
melatonin
mitochondria
reactive oxygen species
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
20 Aug 2022
20 Aug 2022
Historique:
received:
29
07
2022
revised:
18
08
2022
accepted:
19
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
27
8
2022
Statut:
epublish
Résumé
Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have evolved as regulators of important signaling pathways. In this context, tumor cells have an altered redox balance compared to normal cells, which can be targeted as an antitumoral therapy by ROS levels and by decreasing the capacity of the antioxidant system, leading to programmed cell death. Melatonin is of particular importance in the development of innovative cancer treatments due to its oncostatic impact and lack of adverse effects. Despite being widely recognized as a pro-oxidant molecule in tumor cells, the mechanism of action of melatonin remains unclear, which has hindered its use in clinical treatments. The current review aims to describe and clarify the proposed mechanism of action of melatonin inducing ROS production in cancer cells in order to propose future anti-neoplastic clinical applications.
Identifiants
pubmed: 36009340
pii: antiox11081621
doi: 10.3390/antiox11081621
pmc: PMC9404709
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Ministerio de Ciencia e Innovación
ID : SAF2017-85903-P
Organisme : Ministerio de Economia y Competitividad
ID : PID2020-115112RB-I00
Organisme : Regional Government of Andalusia
ID : P07- CTS- 03135, P10- CTS- 5784, and CTS- 101
Références
Int J Mol Sci. 2017 Apr 17;18(4):
pubmed: 28420185
Biochim Biophys Acta. 2016 Apr;1865(2):176-83
pubmed: 26899267
PLoS One. 2017 Aug 11;12(8):e0183090
pubmed: 28800639
Antioxid Redox Signal. 2018 Mar 10;28(8):643-661
pubmed: 28891317
Cell Death Dis. 2020 Oct 24;11(10):911
pubmed: 33099572
Mol Cell Endocrinol. 2016 Feb 15;422:64-73
pubmed: 26607805
Altern Med Rev. 1999 Oct;4(5):304-29
pubmed: 10559547
News Physiol Sci. 2000 Oct;15:246-250
pubmed: 11390919
Heliyon. 2022 Jan 31;8(1):e08837
pubmed: 35141433
Oxid Med Cell Longev. 2018 Mar 21;2018:3510970
pubmed: 29725496
Biochim Biophys Acta. 2007 Jun;1772(6):629-44
pubmed: 17451912
J Pineal Res. 2001 Mar;30(2):65-74
pubmed: 11270481
Mol Cell. 2016 Mar 3;61(5):667-676
pubmed: 26942671
J Pineal Res. 2010 Mar;48(2):178-84
pubmed: 20449875
Int J Mol Sci. 2014 Aug 13;15(8):14102-21
pubmed: 25123138
Front Endocrinol (Lausanne). 2019 Nov 15;10:791
pubmed: 31803142
Cell Death Dis. 2020 Jan 2;11(1):2
pubmed: 31919413
J Pineal Res. 2011 Mar;50(2):140-9
pubmed: 21062352
Oxid Med Cell Longev. 2019 Feb 28;2019:7187128
pubmed: 30944696
Br J Cancer. 2013 Jul 9;109(1):83-91
pubmed: 23756865
J Pineal Res. 2021 Sep;71(2):e12755
pubmed: 34214200
Oncol Rep. 2015 Mar;33(3):1443-9
pubmed: 25606968
Eur J Biochem. 2003 Mar;270(5):832-40
pubmed: 12603316
Toxicol Appl Pharmacol. 2018 Mar 1;342:1-13
pubmed: 29407771
Neuron. 1994 Nov;13(5):1177-85
pubmed: 7946354
J Pineal Res. 2011 Jan;50(1):78-82
pubmed: 20969621
Anticancer Res. 2018 Jul;38(7):3951-3960
pubmed: 29970517
Theranostics. 2021 Mar 4;11(10):4839-4857
pubmed: 33754031
FEBS Lett. 2001 Aug 3;502(3):127-31
pubmed: 11583113
Brain Res Bull. 2020 Oct;163:40-48
pubmed: 32679060
J Pineal Res. 2015 Jan;58(1):34-49
pubmed: 25388914
Clin Exp Pharmacol Physiol. 2021 Dec;48(12):1712-1723
pubmed: 34396568
Molecules. 2018 Feb 27;23(3):
pubmed: 29495460
J Pineal Res. 2022 Aug 19;:e12824
pubmed: 35986493
Curr Mol Pharmacol. 2018;11(4):326-335
pubmed: 30173656
J Pineal Res. 2020 Oct;69(3):e12676
pubmed: 32597503
Semin Cell Dev Biol. 2018 Aug;80:50-64
pubmed: 28587975
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Bioimpacts. 2021;11(4):253-261
pubmed: 34631487
Cell Mol Life Sci. 2008 Dec;65(24):3981-99
pubmed: 18766298
Int J Mol Sci. 2021 Jan 14;22(2):
pubmed: 33466614
J Pineal Res. 2009 May;46(4):415-21
pubmed: 19552765
Toxicol Appl Pharmacol. 2013 Dec 15;273(3):442-55
pubmed: 24121054
Cell Death Differ. 2021 Nov;28(11):3105-3124
pubmed: 34021267
Toxicol Appl Pharmacol. 2009 Jul 15;238(2):170-7
pubmed: 19460395
Toxicol Appl Pharmacol. 2009 Aug 15;239(1):37-45
pubmed: 19463840
Drug Resist Updat. 2018 May;38:1-11
pubmed: 29857814
Antioxidants (Basel). 2021 Apr 14;10(4):
pubmed: 33919790
Mol Med Rep. 2015 Aug;12(2):2275-82
pubmed: 25873273
Front Mol Biosci. 2020 Jul 29;7:163
pubmed: 32850957
Genes Cancer. 2013 Mar;4(3-4):118-24
pubmed: 24020003
Physiol Rev. 2014 Jul;94(3):909-50
pubmed: 24987008
J Pineal Res. 2017 Mar;62(2):
pubmed: 28109165
Front Physiol. 2017 Jun 27;8:428
pubmed: 28701960
J Pineal Res. 2018 Apr;64(3):
pubmed: 29247557
Curr Med Chem. 2021;28(18):3514-3534
pubmed: 32814521
PLoS One. 2015 Dec 11;10(12):e0144517
pubmed: 26656265
J Pineal Res. 2013 Sep;55(2):121-30
pubmed: 23551342
Mol Pharmacol. 2000 Nov;58(5):967-75
pubmed: 11040043
Antioxidants (Basel). 2019 Aug 06;8(8):
pubmed: 31390791
Redox Biol. 2020 Sep;36:101632
pubmed: 32863233
Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E7997-E8006
pubmed: 28874589
J Pineal Res. 2014 Sep;57(2):131-46
pubmed: 25060102
Int J Mol Sci. 2020 Jul 14;21(14):
pubmed: 32674468
Life Sci. 2019 Jul 1;228:228-241
pubmed: 31077716
Biochimie. 2022 May 23;200:44-59
pubmed: 35618158
Heliyon. 2020 Oct 13;6(10):e05159
pubmed: 33088945
J Pineal Res. 2012 Mar;52(2):217-27
pubmed: 21884551
J Natl Cancer Inst. 2017 Nov 1;109(11):
pubmed: 29059435
Biol Signals Recept. 2000 May-Aug;9(3-4):137-59
pubmed: 10899700
Biomol Ther (Seoul). 2018 May 1;26(3):313-321
pubmed: 28822989
J Biol Chem. 2008 Aug 15;283(33):22700-8
pubmed: 18541534
Redox Biol. 2017 Aug;12:208-215
pubmed: 28259101
Life Sci. 2017 Sep 15;185:38-45
pubmed: 28739305
Anat Rec (Hoboken). 2019 Sep;302(9):1544-1551
pubmed: 30809951
J Pineal Res. 2018 Sep;65(2):e12491
pubmed: 29575122
Stem Cell Res Ther. 2020 Jun 29;11(1):259
pubmed: 32600435
Curr Top Med Chem. 2007;7(3):297-309
pubmed: 17305572
Restor Neurol Neurosci. 1998 Jun;12(2-3):143-50
pubmed: 12671309
Eur J Pharmacol. 2013 Sep 5;715(1-3):219-29
pubmed: 23726949
FASEB J. 2000 Sep;14(12):1677-9
pubmed: 10973915
J Pineal Res. 2016 Oct;61(3):253-78
pubmed: 27500468
Molecules. 2022 Jan 21;27(3):
pubmed: 35163973
J Neurosci Res. 2002 Jan 15;67(2):211-24
pubmed: 11782965
Anticancer Res. 2018 Apr;38(4):1993-2000
pubmed: 29599315
Free Radic Biol Med. 2001 May 15;30(10):1137-44
pubmed: 11369504
Oncotarget. 2016 Jan 19;7(3):2985-3001
pubmed: 26672764
Int J Oncol. 2018 Dec;53(6):2319-2331
pubmed: 30334567
Aging (Albany NY). 2021 Sep 27;13(18):22502-22515
pubmed: 34580235
Neuroscience. 2015 Dec 17;311:398-414
pubmed: 26523980
Biomed Pharmacother. 2019 Apr;112:108690
pubmed: 30798124
Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11960-5
pubmed: 11035810
Curr Neuropharmacol. 2010 Sep;8(3):194-210
pubmed: 21358970
Oxid Med Cell Longev. 2020 May 28;2020:5406284
pubmed: 32566089