Investigation of Blood Coagulation Using Impedance Spectroscopy: Toward Innovative Biomarkers to Assess Fibrinogenesis and Clot Retraction.
blood coagulation
clot retraction
clotting time
confocal microscopy
electrical biomarker
fibrinogenesis
impedance spectroscopy
thrombosis
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
29 Jul 2022
29 Jul 2022
Historique:
received:
26
06
2022
revised:
18
07
2022
accepted:
27
07
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
27
8
2022
Statut:
epublish
Résumé
This study focused on a coagulation assessment based on the novel technique of blood-impedance-magnitude measurement. With the impedance characterization of recalcified human blood, it was possible to identify two significative biomarkers (i.e., measurable indicators) related to fibrin formation (1st marker) and clot retraction (2nd marker). The confocal microscopy of clotting blood provided a complete visual analysis of all the events occurring during coagulation, validating the significance of the impedance biomarkers. By analyzing the impedance phase angle (
Identifiants
pubmed: 36009382
pii: biomedicines10081833
doi: 10.3390/biomedicines10081833
pmc: PMC9404805
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Thromb Res. 2012 Jun;129(6):681-7
pubmed: 22221936
J Thromb Haemost. 2020 Aug;18(8):1813-1838
pubmed: 32356929
Biophys J. 2017 Feb 28;112(4):714-723
pubmed: 28256231
Diagnostics (Basel). 2022 May 16;12(5):
pubmed: 35626393
Biosensors (Basel). 2021 Nov 22;11(11):
pubmed: 34821686
J Thromb Haemost. 2007 Jun;5(6):1106-12
pubmed: 17388803
Blood. 2017 Dec 7;130(23):2453-2462
pubmed: 29074499
Vet Clin Pathol. 2011 Jun;40(2):140-53
pubmed: 21446994
Hamostaseologie. 2006 Aug;26(3 Suppl 1):S20-9
pubmed: 16953288
Crit Rev Biochem Mol Biol. 2015;50(4):326-36
pubmed: 26018600
IEEE Access. 2021;9:152322-152332
pubmed: 34888126
PLoS One. 2022 May 13;17(5):e0267980
pubmed: 35560137
Circulation. 2007 Feb 27;115(8):1051-8
pubmed: 17325255
Platelets. 2022 Apr 3;33(3):416-424
pubmed: 34115551
Nat Commun. 2017 Nov 2;8(1):1274
pubmed: 29097692
Small. 2016 Aug;12(29):3926-34
pubmed: 27248117
J Thromb Haemost. 2015 Jun;13 Suppl 1:S72-81
pubmed: 26149053
J Biomed Mater Res B Appl Biomater. 2007 Jul;82(1):100-8
pubmed: 17078085
Adv Healthc Mater. 2019 Nov;8(21):e1900527
pubmed: 31612646
Blood Coagul Fibrinolysis. 2005 Sep;16(6):447-52
pubmed: 16093737
ACS Appl Mater Interfaces. 2017 Nov 22;9(46):40107-40116
pubmed: 29091393
Front Physiol. 2020 Jul 14;11:843
pubmed: 32765300
Thromb Res. 2010 Apr;125(4):353-6
pubmed: 19942257
Toxicol Pathol. 2011 Jan;39(1):273-80
pubmed: 21119054
Oxid Med Cell Longev. 2020 Feb 13;2020:5756382
pubmed: 32148652
Scand J Trauma Resusc Emerg Med. 2013 Apr 16;21:29
pubmed: 23587157
Perfusion. 2011 Jul;26(4):334-40
pubmed: 21565974
Lancet. 2000 May 6;355(9215):1627-32
pubmed: 10821379
J Electr Bioimpedance. 2018 Dec 31;9(1):142-158
pubmed: 33584930