Elevated Vascular Sympathetic Neurotransmission and Remodelling Is a Common Feature in a Rat Model of Foetal Programming of Hypertension and SHR.
fibrosis
foetal programming of hypertension
foetal undernutrition
sympathetic innervation
sympathetic neurotransmission
vascular remodelling
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
05 Aug 2022
05 Aug 2022
Historique:
received:
01
07
2022
revised:
01
08
2022
accepted:
04
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
27
8
2022
Statut:
epublish
Résumé
Hypertension is of unknown aetiology, with sympathetic nervous system hyperactivation being one of the possible contributors. Hypertension may have a developmental origin, owing to the exposure to adverse factors during the intrauterine period. Our hypothesis is that sympathetic hyperinnervation may be implicated in hypertension of developmental origins, being this is a common feature with essential hypertension. Two-animal models were used: spontaneously hypertensive rats (SHR-model of essential hypertension) and offspring from dams exposed to undernutrition (MUN-model of developmental hypertension), with their respective controls. In adult males, we assessed systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), sympathetic nerve function (
Identifiants
pubmed: 36009448
pii: biomedicines10081902
doi: 10.3390/biomedicines10081902
pmc: PMC9405620
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fundação para a Ciência e Tecnologia
ID : UIDB/QUI/50006/2020
Organisme : Spanish Ministry of Science and Innovation
ID : TI 2018-097504-B-I00
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
J Physiol. 2003 Oct 1;552(Pt 1):185-95
pubmed: 12844513
Am J Obstet Gynecol. 2007 May;196(5):486.e1-8
pubmed: 17466715
Eur J Pharmacol. 2004 Nov 3;504(1-2):17-25
pubmed: 15507216
Hypertens Res. 2016 Jul;39(7):501-5
pubmed: 26911229
Reprod Sci. 2014 May;21(5):601-11
pubmed: 24155066
Am J Physiol Regul Integr Comp Physiol. 2005 Jan;288(1):R80-4
pubmed: 15458966
Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R745-53
pubmed: 17507434
Diabet Med. 2000 Dec;17(12):848-53
pubmed: 11168327
J Dev Physiol. 1983 Apr;5(2):77-87
pubmed: 6853981
J Epidemiol Community Health. 2014 Jun;68(6):542-9
pubmed: 24616351
Circulation. 2003 Aug 5;108(5):566-71
pubmed: 12860905
Kidney Int. 2001 Jan;59(1):238-45
pubmed: 11135076
Reprod Sci. 2011 Feb;18(2):180-9
pubmed: 20978179
Neurochem Int. 2003 Feb;42(3):261-7
pubmed: 12427480
Eur J Neurosci. 2008 Aug;28(4):744-58
pubmed: 18671739
Hypertens Res. 2009 Aug;32(8):658-64
pubmed: 19521419
Physiol Res. 2015;64(4):547-59
pubmed: 25470520
PLoS One. 2014 Aug 26;9(8):e105540
pubmed: 25158061
J Endocrinol. 2015 Nov;227(2):117-27
pubmed: 26475702
Compr Physiol. 2015 Apr;5(2):997-1025
pubmed: 25880521
Circ Res. 2007 Mar 2;100(4):520-6
pubmed: 17255528
J Physiol. 2018 Jun;596(12):2345-2358
pubmed: 29604078
Int J Hypertens. 2013;2013:808353
pubmed: 23970958
Chin J Traumatol. 2018 Oct;21(5):293-300
pubmed: 30342984
Clin Invest Med. 1983;6(3):191-5
pubmed: 6652985
Reprod Sci. 2010 Mar;17(3):227-38
pubmed: 19923380
Can Vet J. 2003 Nov;44(11):885-97
pubmed: 14664351
J Physiol. 2001 Jun 1;533(Pt 2):561-70
pubmed: 11389212
Am J Physiol Renal Physiol. 2004 Aug;287(2):F262-7
pubmed: 15100095
Cardiovasc Res. 2006 Feb 15;69(3):764-71
pubmed: 16199024
Drug Discov Today. 2020 Apr;25(4):739-747
pubmed: 32032706
Nephrol Dial Transplant. 2010 Feb;25(2):380-8
pubmed: 19793932
Rev Reprod. 1997 May;2(2):105-12
pubmed: 9414472
Hypertension. 2003 Mar;41(3):457-62
pubmed: 12623943
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Pediatr Res. 2004 Jun;55(6):1042-9
pubmed: 15071169
Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H804-12
pubmed: 16565305
Ann Intern Med. 2003 Nov 4;139(9):761-76
pubmed: 14597461
J Cardiovasc Pharmacol Ther. 2005 Sep;10(3):197-203
pubmed: 16211209
Endothelium. 2007 Nov-Dec;14(6):353-60
pubmed: 18080872
Clin Exp Pharmacol Physiol. 2016 Dec;43(12):1177-1184
pubmed: 27612187
Nutr Metab Cardiovasc Dis. 2015 Jan;25(1):123-30
pubmed: 25287449
Front Physiol. 2018 May 23;9:602
pubmed: 29875698
Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R1-R10
pubmed: 16352854
Hypertension. 1997 Dec;30(6):1455-64
pubmed: 9403567
Hypertension. 2013 Jan;61(1):180-6
pubmed: 23150514
Asia Oceania J Obstet Gynaecol. 1991 Dec;17(4):341-8
pubmed: 1801680
Neurochem Int. 2013 Mar;62(4):399-405
pubmed: 23416044
Am J Public Health. 1996 Mar;86(3):347-54
pubmed: 8604759
J Intern Med. 2007 May;261(5):480-7
pubmed: 17444887
Peptides. 2016 Apr;78:87-90
pubmed: 26944358
Am J Clin Nutr. 2011 Dec;94(6 Suppl):1980S-1985S
pubmed: 21613560
Clin Sci (Lond). 1998 Feb;94(2):149-55
pubmed: 9536923
J Vasc Res. 2005 Jul-Aug;42(4):348-58
pubmed: 16015033
Biomedicines. 2020 Oct 16;8(10):
pubmed: 33081182
PLoS One. 2017 Feb 17;12(2):e0171544
pubmed: 28212445
J Transl Med. 2015 Oct 15;13:327
pubmed: 26472248
Neurogastroenterol Motil. 2008 Nov;20(11):1212-26
pubmed: 18643894
Hypertension. 2014 Dec;64(6):1321-7
pubmed: 25267800
J Auton Nerv Syst. 1983 May;8(1):25-32
pubmed: 6875199
Cardiovasc Res. 2004 Sep 1;63(4):739-46
pubmed: 15306230
Hypertension. 2011 Mar;57(3):620-6
pubmed: 21220702
Early Hum Dev. 2015 Mar;91(3):169-72
pubmed: 25658874
Endocrinology. 2001 May;142(5):1692-702
pubmed: 11316731
J Physiol. 2018 Dec;596(23):5791-5806
pubmed: 29277911
J Nutr Biochem. 2015 Dec;26(12):1650-9
pubmed: 26350253
Curr Opin Neurobiol. 2000 Jun;10(3):328-36
pubmed: 10851182
Int J Mol Sci. 2022 Jan 22;23(3):
pubmed: 35163158
Matern Child Nutr. 2014 Apr;10(2):226-33
pubmed: 22625423
PLoS One. 2015 Jun 15;10(6):e0129224
pubmed: 26075386
Curr Vasc Pharmacol. 2014 Jan;12(1):4-15
pubmed: 23905597
Curr Opin Nephrol Hypertens. 2012 Jan;21(1):46-51
pubmed: 22080859
Neuroimmunomodulation. 2001;9(1):41-8
pubmed: 11435751
J Pharmacol Sci. 2013;122(2):59-70
pubmed: 23782593
Hypertension. 2014 Feb;63(2):324-9
pubmed: 24191284
Vascul Pharmacol. 2019 Jun;117:27-34
pubmed: 30326265
Clin Sci (Lond). 2008 Jan;114(1):1-17
pubmed: 18047465
PLoS Biol. 2020 Jul 14;18(7):e3000410
pubmed: 32663219
Peptides. 2016 Dec;86:133-144
pubmed: 27818235
Clin Sci (Lond). 2021 Aug 13;135(15):1791-1804
pubmed: 34338771
Brain Res. 1993 Sep 3;621(1):79-86
pubmed: 8221076
Blood Vessels. 1980;17(1):1-15
pubmed: 7357092
Exp Physiol. 2015 Dec;100(12):1400-11
pubmed: 26263443
Am J Physiol Heart Circ Physiol. 2008 Dec;295(6):H2299-307
pubmed: 18849339
BMJ. 1988 Jul 9;297(6641):134-5
pubmed: 3408942
J Am Soc Hypertens. 2016 May;10(5):457-66
pubmed: 27052349
Jpn Circ J. 1963 Mar;27:282-93
pubmed: 13939773
Pediatr Nephrol. 2015 Apr;30(4):549-60
pubmed: 24609827
Exp Physiol. 2010 May;95(5):581-6
pubmed: 20008032
J Clin Hypertens (Greenwich). 2021 May;23(5):1068-1076
pubmed: 33675159
Circ Res. 1981 Mar;48(3):309-19
pubmed: 7460205
Drugs Future. 2004 Dec;29(12):1235-1244
pubmed: 16871320
Am J Obstet Gynecol. 1999 Jul;181(1):S22-7
pubmed: 10411787