Hypergravity Attenuates Reactivity in Primary Murine Astrocytes.
astrocyte reactivity
astrogliosis
cytoskeletal remodeling
glial scarring
gravitational biology
hypergravity
neuronal regeneration
neuroscience
primary astrocytes
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
13 Aug 2022
13 Aug 2022
Historique:
received:
04
07
2022
revised:
31
07
2022
accepted:
11
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
27
8
2022
Statut:
epublish
Résumé
Neuronal activity is the key modulator of nearly every aspect of behavior, affecting cognition, learning, and memory as well as motion. Hence, disturbances of the transmission of synaptic signals are the main cause of many neurological disorders. Lesions to nervous tissues are associated with phenotypic changes mediated by astrocytes becoming reactive. Reactive astrocytes form the basis of astrogliosis and glial scar formation. Astrocyte reactivity is often targeted to inhibit axon dystrophy and thus promote neuronal regeneration. Here, we aim to understand the impact of gravitational loading induced by hypergravity to potentially modify key features of astrocyte reactivity. We exposed primary murine astrocytes as a model system closely resembling the in vivo reactivity phenotype on custom-built centrifuges for cultivation as well as for live-cell imaging under hypergravity conditions in a physiological range (2
Identifiants
pubmed: 36009513
pii: biomedicines10081966
doi: 10.3390/biomedicines10081966
pmc: PMC9405820
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : German Aerospace Center
ID : NeuroSpace
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