Design, Synthesis and Mechanistic Studies of Novel Isatin-Pyrazole Hydrazone Conjugates as Selective and Potent Bacterial MetAP Inhibitors.
ESKAPE
Isatin-pyrazole hydrazone
MDR
MetAP
antibacterial
cytotoxicity
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
19 Aug 2022
19 Aug 2022
Historique:
received:
03
08
2022
revised:
13
08
2022
accepted:
16
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
27
8
2022
Statut:
epublish
Résumé
Methionine aminopeptidases (MetAPs) are attractive drug targets due to their essential role in eukaryotes as well as prokaryotic cells. In this study, biochemical assays were performed on newly synthesized Isatin-pyrazole hydrazones (
Identifiants
pubmed: 36009995
pii: antibiotics11081126
doi: 10.3390/antibiotics11081126
pmc: PMC9405123
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Science and Engineering Research Board
ID : CRG/2018/003967
Organisme : Science and Engineering Research Board
ID : EMR/2015/000461
Organisme : Science and Engineering Research Board
ID : CRG/2019/006013
Organisme : Science and Engineering Research Board
ID : ECR/ 2016/000288
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