Neurons: The Interplay between Cytoskeleton, Ion Channels/Transporters and Mitochondria.
axonal excitability
biomarkers
cytoskeleton
ion channels
transporters
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
11 08 2022
11 08 2022
Historique:
received:
19
04
2022
revised:
06
08
2022
accepted:
09
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
Neurons are permanent cells whose key feature is information transmission via chemical and electrical signals. Therefore, a finely tuned homeostasis is necessary to maintain function and preserve neuronal lifelong survival. The cytoskeleton, and in particular microtubules, are far from being inert actors in the maintenance of this complex cellular equilibrium, and they participate in the mobilization of molecular cargos and organelles, thus influencing neuronal migration, neuritis growth and synaptic transmission. Notably, alterations of cytoskeletal dynamics have been linked to alterations of neuronal excitability. In this review, we discuss the characteristics of the neuronal cytoskeleton and provide insights into alterations of this component leading to human diseases, addressing how these might affect excitability/synaptic activity, as well as neuronal functioning. We also provide an overview of the microscopic approaches to visualize and assess the cytoskeleton, with a specific focus on mitochondrial trafficking.
Identifiants
pubmed: 36010576
pii: cells11162499
doi: 10.3390/cells11162499
pmc: PMC9406945
pii:
doi:
Substances chimiques
Ion Channels
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Philos Trans R Soc Lond B Biol Sci. 2005 Jun 29;360(1458):1281-307
pubmed: 16147523
Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12272-7
pubmed: 11572947
J Neurosci. 2003 Apr 1;23(7):2655-64
pubmed: 12684451
J Peripher Nerv Syst. 2019 Oct;24 Suppl 2:S63-S73
pubmed: 31647152
Mol Neurobiol. 2016 Sep;53(7):5013-24
pubmed: 26377107
Dev Neurobiol. 2012 Feb;72(2):145-52
pubmed: 21557508
Nat Neurosci. 2013 Jul;16(7):790-7
pubmed: 23799471
Cold Spring Harb Perspect Biol. 2016 Nov 1;8(11):
pubmed: 27803112
Nat Methods. 2014 Jul;11(7):731-3
pubmed: 24859753
Cell. 2008 Jan 11;132(1):137-48
pubmed: 18191227
Exp Cell Res. 2006 Sep 10;312(15):2872-9
pubmed: 16824517
Cells. 2021 Jul 12;10(7):
pubmed: 34359929
JCI Insight. 2022 Mar 22;7(6):
pubmed: 35133982
Methods Mol Biol. 2017;1663:45-64
pubmed: 28924658
Brain Res. 1988 Dec 6;474(2):279-86
pubmed: 3208133
Ciba Found Symp. 1975;(31):191-203
pubmed: 1041242
J Neurocytol. 1978 Oct;7(5):571-82
pubmed: 214525
Biochim Biophys Acta. 2014 Feb;1838(2):514-20
pubmed: 23770358
Neuron. 2005 Dec 8;48(5):737-42
pubmed: 16337912
Am J Hum Genet. 2014 Apr 3;94(4):634-41
pubmed: 24702957
J Neurosci. 2000 Jun 15;20(12):4545-54
pubmed: 10844024
Biochim Biophys Acta. 2006 Nov-Dec;1762(11-12):1094-108
pubmed: 16730956
Annu Rev Biophys. 2021 May 6;50:549-574
pubmed: 33957056
Transl Psychiatry. 2017 Dec 11;7(12):1278
pubmed: 29225346
J Neurosci. 2007 May 30;27(22):5903-14
pubmed: 17537961
Int J Mol Sci. 2021 Jun 07;22(11):
pubmed: 34200511
J Cell Biol. 2014 Mar 31;204(7):1087-98
pubmed: 24687278
Annu Rev Biochem. 2004;73:749-89
pubmed: 15189158
J Neurosci. 2006 Mar 8;26(10):2599-613
pubmed: 16525039
Epilepsia. 2010 May;51(5):883-90
pubmed: 20067507
Cold Spring Harb Perspect Biol. 2017 Apr 3;9(4):
pubmed: 28373358
Acta Neuropathol. 2018 Jan;135(1):131-148
pubmed: 28780615
Cell Cycle. 2015;14(5):712-20
pubmed: 25590687
Trends Biochem Sci. 2015 Oct;40(10):597-610
pubmed: 26410600
Biophys J. 2014 Jan 7;106(1):L01-3
pubmed: 24411266
Int J Biol Macromol. 2019 Feb 1;122:1080-1089
pubmed: 30218739
J Cell Biol. 2007 Jun 4;177(5):857-70
pubmed: 17548513
Mol Cell Neurosci. 2016 Dec;77:113-124
pubmed: 27756615
J Comp Neurol. 2000 Nov 20;427(3):340-50
pubmed: 11054697
Cells. 2020 Mar 31;9(4):
pubmed: 32244264
Dev Neurobiol. 2021 Apr;81(3):284-299
pubmed: 32302463
Mult Scler. 2022 Sep;28(10):1553-1561
pubmed: 35282740
Neuroendocrinology. 2022;112(4):324-337
pubmed: 34034255
Arch Toxicol. 2020 Jul;94(7):2517-2522
pubmed: 32333051
Trends Biochem Sci. 2019 Oct;44(10):837-848
pubmed: 31078399
Biol Bull. 2003 Oct;205(2):190-1
pubmed: 14583523
Curr Top Membr. 2016;77:185-233
pubmed: 26781833
Neurology. 2016 Sep 27;87(13):1329-36
pubmed: 27581216
J Diabetes Res. 2020 Sep 16;2020:3634974
pubmed: 33015191
J Neuropathol Exp Neurol. 2012 Dec;71(12):1100-12
pubmed: 23147510
J Alzheimers Dis. 2022;87(1):131-140
pubmed: 35275542
Expert Opin Drug Metab Toxicol. 2019 Jun;15(6):487-497
pubmed: 31116618
J Neurosci. 2004 Feb 4;24(5):1236-44
pubmed: 14762142
Mol Neurobiol. 2008 Dec;38(3):270-84
pubmed: 18987787
Biophys Rev. 2018 Dec;10(6):1553-1569
pubmed: 30392063
Brain. 2003 Mar;126(Pt 3):590-7
pubmed: 12566280
Methods. 2015 Oct 15;88:109-21
pubmed: 26079924
J Neurochem. 2014 Apr;129(2):213-220
pubmed: 24147838
Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18982-7
pubmed: 19028874
Res Publ Assoc Res Nerv Ment Dis. 1987;65:89-102
pubmed: 2455314
Nat Rev Neurosci. 2005 Aug;6(8):603-14
pubmed: 16062169
Am J Hum Genet. 2016 Apr 7;98(4):597-614
pubmed: 27040688
Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):
pubmed: 33468672
J Cell Biol. 1983 Oct;97(4):963-73
pubmed: 6352712
J Neurosci. 2021 Jan 6;41(1):11-27
pubmed: 33408133
PLoS Biol. 2019 Jan 7;17(1):e3000100
pubmed: 30615611
Science. 2013 Jan 25;339(6118):452-6
pubmed: 23239625
Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8047-E8056
pubmed: 30082388
Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8870-5
pubmed: 16735477
Neuromuscul Disord. 2012 Aug;22(8):699-711
pubmed: 22595202
Sci Rep. 2017 Sep 18;7(1):11781
pubmed: 28924236
Toxics. 2015 Aug 07;3(3):322-341
pubmed: 29051467
J Peripher Nerv Syst. 2019 Oct;24 Suppl 2:S40-S51
pubmed: 31647157
Neurol Neuroimmunol Neuroinflamm. 2022 Mar 3;9(3):
pubmed: 35241571
Front Cell Neurosci. 2020 Jul 30;14:175
pubmed: 32848607
J Comp Neurol. 1992 Mar 22;317(4):396-406
pubmed: 1578003
Neuron. 2014 Oct 22;84(2):292-309
pubmed: 25374356
J Opt Soc Am B. 2017;34(5):B64-B77
pubmed: 29386746
J Neurochem. 2006 Sep;98(5):1345-52
pubmed: 16787401
Sci Rep. 2020 May 14;10(1):7995
pubmed: 32409710
Ageing Res Rev. 2022 Sep;80:101667
pubmed: 35714855
J Physiol. 2018 Jul;596(14):2773-2782
pubmed: 29380377
J Cell Biol. 2002 Jan 21;156(2):337-48
pubmed: 11807096
J Neurochem. 2014 Apr;129(2):221-34
pubmed: 24164353
J Biol Chem. 1997 Mar 7;272(10):6510-8
pubmed: 9045676
ACS Nano. 2020 Feb 25;14(2):1856-1865
pubmed: 31909985
J Hum Genet. 2022 Mar 18;:
pubmed: 35304567
J Physiol. 2006 May 15;573(Pt 1):17-34
pubmed: 16527853
Microsc Res Tech. 2021 Feb;84(2):217-237
pubmed: 32915487
Neuron. 2013 Feb 6;77(3):485-502
pubmed: 23395375
N Engl J Med. 2011 Dec 22;365(25):2377-88
pubmed: 22187985
Mol Med Rep. 2015 Apr;11(4):2729-34
pubmed: 25482575
Neurology. 2018 Feb 6;90(6):e518-e524
pubmed: 29321234
Nat Neurosci. 2008 Feb;11(2):178-86
pubmed: 18204443
Epilepsia. 2008 Jul;49(7):1239-76
pubmed: 18397299
J Microsc. 2021 Feb;281(2):125-137
pubmed: 32691851
Nat Rev Neurol. 2018 Oct;14(10):577-589
pubmed: 30171200
Nat Rev Mol Cell Biol. 2019 Jan;20(1):38-54
pubmed: 30323238
Science. 1982 Dec 10;218(4577):1129-31
pubmed: 6183745
J Neurochem. 2015 Nov;135(4):643-58
pubmed: 26222552
J Integr Neurosci. 2010 Jun;9(2):103-22
pubmed: 20589950
Neuroscientist. 2010 Feb;16(1):28-39
pubmed: 19429889
Methods Cell Biol. 2016;131:91-106
pubmed: 26794509
J Neurophysiol. 2006 Jun;95(6):3480-95
pubmed: 16495357
Am J Physiol Cell Physiol. 2021 May 1;320(5):C696-C702
pubmed: 33471624
Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):E2696-705
pubmed: 23821747
Biophys J. 2011 Sep 7;101(5):1277-84
pubmed: 21889466
J Cell Biol. 2003 Nov 10;163(3):445-50
pubmed: 14610051
Sci Rep. 2018 Jul 24;8(1):11138
pubmed: 30042445
Ann Transl Med. 2020 Jul;8(14):863
pubmed: 32793707
F1000Res. 2016 May 25;5:
pubmed: 27303635
J Cell Biol. 2008 Jan 14;180(1):173-86
pubmed: 18180363
Int J Cancer. 2010 Jan 1;126(1):256-65
pubmed: 19626589
J Cell Biol. 2021 Jul 5;220(7):
pubmed: 34014261
Curr Biol. 2000 Jul 13;10(14):865-8
pubmed: 10899006
Neuron. 2012 Dec 6;76(5):945-61
pubmed: 23217743
J Cell Biol. 1998 Nov 30;143(5):1295-304
pubmed: 9832557
Epilepsy Res. 2019 Aug;154:90-96
pubmed: 31112902
Curr Opin Neurobiol. 2003 Oct;13(5):607-11
pubmed: 14630226
Nat Commun. 2021 Jul 28;12(1):4578
pubmed: 34321481
J Physiol. 2021 Jan;599(2):431-441
pubmed: 32034761
Prog Neurobiol. 2011 Jul;94(2):91-101
pubmed: 21527310
J Cell Biochem. 1999 Jul 1;74(1):11-22
pubmed: 10381257
Epilepsia. 2013 Mar;54(3):551-63
pubmed: 23350722
Cell Rep. 2015 Mar 3;10(8):1246-51
pubmed: 25732815
Nat Rev Neurosci. 2005 Mar;6(3):201-14
pubmed: 15711600
Trends Cell Biol. 2017 Jun;27(6):403-416
pubmed: 28228333
J Peripher Nerv Syst. 2018 Sep;23(3):174-177
pubmed: 29974556
Cell Tissue Res. 1981;214(2):323-41
pubmed: 6894105
Mol Cell Neurosci. 2011 Jan;46(1):9-20
pubmed: 20817096
J Cell Sci. 2007 Mar 15;120(Pt 6):953-63
pubmed: 17311847
Exp Neurol. 2018 Sep;307:129-132
pubmed: 29908147
J Cell Biol. 2017 Jun 5;216(6):1689-1703
pubmed: 28432079
Cell. 2009 Jan 9;136(1):163-74
pubmed: 19135897
J Neurosci. 2007 Mar 14;27(11):3017-29
pubmed: 17360925
EMBO J. 2019 Aug 1;38(15):e101183
pubmed: 31267565
J Neurosci. 2008 Jul 16;28(29):7260-72
pubmed: 18632930
Neuron. 2005 Jul 21;47(2):215-29
pubmed: 16039564
Science. 1982 Dec 10;218(4577):1127-9
pubmed: 6183744
Nat Med. 2011 Jul 24;17(8):968-74
pubmed: 21785432
Cell Mol Life Sci. 2020 Apr;77(8):1511-1530
pubmed: 31659414
Sensors (Basel). 2013 Mar 28;13(4):4170-91
pubmed: 23539026
Nat Commun. 2021 Jan 4;12(1):83
pubmed: 33397950
Nat Commun. 2020 Jun 19;11(1):3123
pubmed: 32561740
J Neurochem. 2019 May;149(4):471-487
pubmed: 30828804
J Peripher Nerv Syst. 2019 Oct;24 Suppl 2:S52-S62
pubmed: 31647153
Opt Lett. 2009 Jan 1;34(1):79-81
pubmed: 19109646
Front Cell Neurosci. 2017 May 09;11:136
pubmed: 28536506
J Vis Exp. 2020 Feb 9;(156):
pubmed: 32090993
Am J Physiol Cell Physiol. 2008 Aug;295(2):C538-44
pubmed: 18562484
J Biol Chem. 2003 Jul 25;278(30):27333-9
pubmed: 12716895
Neuron. 2015 Aug 5;87(3):492-506
pubmed: 26247859
Brain Res Mol Brain Res. 2002 Jan 31;98(1-2):145-52
pubmed: 11834307
Science. 2012 Feb 3;335(6068):551
pubmed: 22301313
Nat Rev Neurosci. 2017 Dec;18(12):713-726
pubmed: 29097785
Int Rev Neurobiol. 1996;39:113-43
pubmed: 8894846
Neurol Genet. 2018 Jun 05;4(3):e244
pubmed: 29888333
J Cell Biol. 2018 Jul 2;217(7):2235-2246
pubmed: 29752396
Expert Opin Drug Metab Toxicol. 2017 Mar;13(3):241-243
pubmed: 27819147
J Vis Exp. 2020 May 12;(159):
pubmed: 32478717
Crit Rev Oncol Hematol. 2012 Apr;82(1):51-77
pubmed: 21908200
EMBO J. 2018 Feb 1;37(3):321-336
pubmed: 29311115
J Neurosci. 1986 Mar;6(3):714-22
pubmed: 3514816
Protein Sci. 2020 Jun;29(6):1269-1284
pubmed: 32056317
Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6952-E6961
pubmed: 28760966
IEEE Trans Biomed Eng. 2019 Dec;66(12):3457-3471
pubmed: 30932816
J Cell Biol. 2021 Oct 4;220(10):
pubmed: 34342639
Nat Cell Biol. 2019 Jun;21(6):768-777
pubmed: 31061466
J Cell Biol. 2003 Apr 14;161(1):55-66
pubmed: 12682084
J Peripher Nerv Syst. 2022 Jun;27(2):166-174
pubmed: 35384143
Science. 2003 Jun 27;300(5628):2091-4
pubmed: 12829783