Current Opportunities for Targeting Dysregulated Neurodevelopmental Signaling Pathways in Glioblastoma.
BMP signaling
GBM subtypes
Hippo signaling
Notch signaling
RA signaling
SHH signaling
TGFβ signaling
Wnt/β-catenin signaling
glioblastoma
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
15 08 2022
15 08 2022
Historique:
received:
07
06
2022
revised:
06
08
2022
accepted:
09
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
Glioblastoma (GBM) is the most common and highly lethal type of brain tumor, with poor survival despite advances in understanding its complexity. After current standard therapeutic treatment, including tumor resection, radiotherapy and concomitant chemotherapy with temozolomide, the median overall survival of patients with this type of tumor is less than 15 months. Thus, there is an urgent need for new insights into GBM molecular characteristics and progress in targeted therapy in order to improve clinical outcomes. The literature data revealed that a number of different signaling pathways are dysregulated in GBM. In this review, we intended to summarize and discuss current literature data and therapeutic modalities focused on targeting dysregulated signaling pathways in GBM. A better understanding of opportunities for targeting signaling pathways that influences malignant behavior of GBM cells might open the way for the development of novel GBM-targeted therapies.
Identifiants
pubmed: 36010607
pii: cells11162530
doi: 10.3390/cells11162530
pmc: PMC9406959
pii:
doi:
Substances chimiques
Temozolomide
YF1K15M17Y
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
J Pharm Sci. 2006 Nov;95(11):2348-60
pubmed: 16886178
Cell Rep. 2020 Jun 9;31(10):107738
pubmed: 32521263
Biomedicines. 2020 Jul 31;8(8):
pubmed: 32752069
Cancers (Basel). 2022 Jan 25;14(3):
pubmed: 35158868
FEBS Open Bio. 2015 Jun 22;5:542-9
pubmed: 26199863
Cancer Res. 2016 Jun 15;76(12):3593-603
pubmed: 27197169
Oligonucleotides. 2007 Summer;17(2):201-12
pubmed: 17638524
Acta Neuropathol. 2018 Aug;136(2):181-210
pubmed: 29967940
PPAR Res. 2016;2016:7175067
pubmed: 27313600
Mol Med. 2010 Jan-Feb;16(1-2):1-9
pubmed: 19809523
Neuro Oncol. 2015 Feb;17(2):266-73
pubmed: 25239666
Nat Commun. 2020 Jul 8;11(1):3406
pubmed: 32641768
EXCLI J. 2022 Feb 14;21:387-399
pubmed: 35368464
Brain. 2013 Feb;136(Pt 2):564-76
pubmed: 23378223
J Biol Chem. 2013 Jul 19;288(29):20868-20882
pubmed: 23723072
Cold Spring Harb Perspect Biol. 2017 Jul 5;9(7):
pubmed: 28062563
Cancer Lett. 1997 Jan 30;112(2):251-6
pubmed: 9066736
PLoS Biol. 2008 Oct 21;6(10):e257
pubmed: 18942891
Acta Biochim Biophys Sin (Shanghai). 2018 Oct 1;50(10):941-949
pubmed: 30165534
Hum Genomics. 2019 Dec 3;13(1):61
pubmed: 31796115
Cell. 2006 Mar 10;124(5):985-96
pubmed: 16530045
Sci Rep. 2019 Jul 22;9(1):10555
pubmed: 31332251
Nature. 2012 Aug 23;488(7412):522-6
pubmed: 22854781
J Neuropathol Exp Neurol. 2011 Jul;70(7):568-77
pubmed: 21666501
Cancers (Basel). 2020 Jun 19;12(6):
pubmed: 32575464
Semin Cancer Biol. 2022 Jul;82:162-175
pubmed: 33640445
Clin Cancer Res. 2019 Jan 15;25(2):844-855
pubmed: 30322879
Cytokine Growth Factor Rev. 2006 Feb-Apr;17(1-2):129-39
pubmed: 16377233
Mol Cancer Ther. 2018 May;17(5):1039-1050
pubmed: 29592882
Pharmaceuticals (Basel). 2021 Jan 12;14(1):
pubmed: 33445425
Oncogene. 2008 Sep 1;27(38):5099-109
pubmed: 18758478
Cells. 2021 Sep 20;10(9):
pubmed: 34572134
Mol Cell Biol. 2001 Sep;21(17):6071-9
pubmed: 11486044
Curr Top Dev Biol. 2010;92:367-409
pubmed: 20816402
Cancer Invest. 2012 Jan;30(1):48-56
pubmed: 22236189
Arch Med Res. 2010 Oct;41(7):519-29
pubmed: 21167391
Oncotarget. 2017 Jun 6;8(23):37511-37524
pubmed: 28415586
Stem Cells. 2010 Jan;28(1):17-28
pubmed: 19921751
J Biol Chem. 2006 Aug 11;281(32):22429-33
pubmed: 16793760
Mol Cell Biochem. 2022 May;477(5):1583-1595
pubmed: 35192123
N Engl J Med. 2009 Sep 17;361(12):1173-8
pubmed: 19726761
J Thorac Oncol. 2013 May;8(5):619-23
pubmed: 23546045
Sci Rep. 2019 Nov 7;9(1):16250
pubmed: 31700049
Front Oncol. 2021 Dec 03;11:718590
pubmed: 34926242
Brain Res Mol Brain Res. 2001 Feb 19;87(1):100-8
pubmed: 11223164
Clin Cancer Res. 2013 Aug 1;19(15):4124-36
pubmed: 23908450
Cancer Biol Ther. 2013 May;14(5):390-8
pubmed: 23380592
Seizure. 2014 Nov;23(10):830-5
pubmed: 25066904
Oncotarget. 2019 Mar 1;10(18):1716-1728
pubmed: 30899443
Cancer Res. 1993 Jun 15;53(12):2736-9
pubmed: 8504413
J Nat Prod. 2020 Mar 27;83(3):770-803
pubmed: 32162523
Cell Death Dis. 2012 Oct 18;3:e412
pubmed: 23076220
Front Immunol. 2021 Nov 25;12:706936
pubmed: 34899682
Medicine (Baltimore). 2020 Feb;99(9):e18997
pubmed: 32118710
Int J Oncol. 2011 Jan;38(1):51-9
pubmed: 21109925
Neurosurgery. 1990 Feb;26(2):248-54
pubmed: 2137904
Cancer Res. 2011 Nov 1;71(21):6764-72
pubmed: 21896639
J Natl Cancer Inst. 2011 Apr 6;103(7):598-606
pubmed: 21346226
Cancer Res. 2011 Dec 1;71(23):7155-67
pubmed: 22006998
Cancers (Basel). 2021 Feb 12;13(4):
pubmed: 33673104
Sci Rep. 2015 Jan 27;5:7979
pubmed: 25623281
Biochem Mol Biol Int. 1995 Aug;36(5):1097-105
pubmed: 7581005
Cold Spring Harb Perspect Biol. 2016 Jun 01;8(6):
pubmed: 27252362
Nature. 1996 Nov 14;384(6605):129-34
pubmed: 8906787
Handb Clin Neurol. 2016;134:97-120
pubmed: 26948350
PLoS One. 2017 Aug 24;12(8):e0181346
pubmed: 28837560
Carcinogenesis. 2016 Jul;37(7):656-68
pubmed: 27207652
Dev Cell. 2009 Jul;17(1):9-26
pubmed: 19619488
Mol Cell Biol. 2002 Nov;22(21):7688-700
pubmed: 12370315
J Clin Oncol. 2011 Sep 10;29(26):3529-34
pubmed: 21825264
J Drug Target. 2017 Jul;25(6):523-531
pubmed: 28140690
Biochem Biophys Res Commun. 2020 Mar 19;523(4):947-953
pubmed: 31964531
Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12550-5
pubmed: 25114226
Front Oncol. 2019 Aug 20;9:779
pubmed: 31482066
J Nucl Med. 2015 Sep;56(9):1310-4
pubmed: 26135113
Glia. 2015 Oct;63(10):1850-9
pubmed: 25944104
N Engl J Med. 2010 Aug 19;363(8):711-23
pubmed: 20525992
Cancer Res. 2011 Sep 15;71(18):6061-72
pubmed: 21788346
Anticancer Res. 2017 Nov;37(11):6047-6053
pubmed: 29061784
J Cancer. 2020 Jan 1;11(3):657-667
pubmed: 31942189
J Pathol. 2014 Sep;234(1):11-22
pubmed: 24604164
J Clin Invest. 2021 Jul 15;131(14):
pubmed: 34138753
Nature. 1997 Oct 9;389(6651):631-5
pubmed: 9335507
Mol Cells. 2014 Jul;37(7):547-53
pubmed: 25078449
PLoS One. 2009 Oct 13;4(10):e7443
pubmed: 19823589
MAbs. 2018 Nov-Dec;10(8):1157-1167
pubmed: 30183492
Neuroscience. 2014 Oct 24;279:44-64
pubmed: 25171789
Cancer Res. 2010 Mar 15;70(6):2455-64
pubmed: 20197461
Cancer Cell. 2010 Jan 19;17(1):98-110
pubmed: 20129251
Cancer Biother Radiopharm. 2011 Feb;26(1):77-83
pubmed: 21355779
Nat Cancer. 2021 Feb;2(2):141-156
pubmed: 33681822
Development. 1996 May;122(5):1373-83
pubmed: 8625826
Int J Dev Biol. 2006;50(6):511-21
pubmed: 16741866
Am J Cancer Res. 2015 Feb 15;5(3):945-55
pubmed: 26045979
Stem Cells Int. 2016;2016:7290686
pubmed: 27433166
Curr Biol. 2007 Jan 23;17(2):165-72
pubmed: 17196391
Nat Cancer. 2021 Feb;2(2):135-137
pubmed: 35122081
Bone Res. 2018 Jan 31;6:2
pubmed: 29423331
Clin Cancer Res. 2008 Jan 1;14(1):123-9
pubmed: 18172261
Cell Physiol Biochem. 2015;37(5):1693-711
pubmed: 26545287
Nature. 2004 Nov 18;432(7015):324-31
pubmed: 15549094
Cell Stem Cell. 2008 May 8;2(5):472-83
pubmed: 18462697
J Clin Oncol. 2004 Nov 1;22(21):4282-9
pubmed: 15514370
Nature. 2006 Dec 7;444(7120):761-5
pubmed: 17151667
Cancer Cell. 2021 Apr 12;39(4):509-528.e20
pubmed: 33577785
Front Cell Dev Biol. 2021 Apr 27;9:659055
pubmed: 34012965
Oncotarget. 2017 Dec 31;9(6):6659-6677
pubmed: 29467918
J Neurooncol. 2017 Jul;133(3):589-594
pubmed: 28510787
Neuro Oncol. 2012 Oct;14(10):1215-26
pubmed: 22962413
Trends Cancer. 2020 Mar;6(3):223-235
pubmed: 32101725
World J Stem Cells. 2021 Jul 26;13(7):877-893
pubmed: 34367482
Cancer Gene Ther. 2020 Sep;27(9):702-714
pubmed: 31619751
Oncol Lett. 2019 Aug;18(2):1938-1948
pubmed: 31423264
J Cancer Res Clin Oncol. 2020 Nov;146(11):2817-2828
pubmed: 32712753
Neoplasia. 2006 Dec;8(12):1072-82
pubmed: 17217625
Mol Cell Biochem. 2011 Mar;349(1-2):1-10
pubmed: 21221726
Cancer Cell. 2015 Dec 14;28(6):730-742
pubmed: 26669487
Int J Radiat Oncol Biol Phys. 2005 Apr 1;61(5):1454-9
pubmed: 15817350
Cell Rep. 2018 Sep 18;24(12):3237-3250
pubmed: 30232005
Dev Neurobiol. 2012 Jul;72(7):1068-84
pubmed: 22489086
Med Oncol. 2021 Feb 18;38(3):31
pubmed: 33599853
Nat Cancer. 2021 Feb;2(2):157-173
pubmed: 35122077
Nat Rev Drug Discov. 2014 Jan;13(1):63-79
pubmed: 24336504
Cancer Res. 2007 Mar 1;67(5):2351-9
pubmed: 17332368
Development. 2011 Jan;138(1):9-22
pubmed: 21138973
Front Cell Dev Biol. 2020 Jul 08;8:605
pubmed: 32733895
Biochim Biophys Acta Gen Subj. 2017 Sep;1861(9):2282-2292
pubmed: 28687190
Clin Exp Metastasis. 2016 Jun;33(5):417-29
pubmed: 26957434
Cancers (Basel). 2020 Dec 26;13(1):
pubmed: 33375286
Cancers (Basel). 2020 Aug 14;12(8):
pubmed: 32823876
Int J Cancer. 2012 Oct 15;131(8):1963-8
pubmed: 22275178
Cancers (Basel). 2019 Mar 01;11(3):
pubmed: 30832246
Toxicol Lett. 2013 Jun 20;220(1):61-9
pubmed: 23542114
Cancer Cell. 2017 Jul 10;32(1):42-56.e6
pubmed: 28697342
BioData Min. 2021 Aug 23;14(1):42
pubmed: 34425860
J Transl Med. 2013 Apr 16;11:100
pubmed: 23590708
J Clin Neurosci. 2009 Feb;16(2):285-94
pubmed: 19091570
iScience. 2020 Aug 21;23(8):101365
pubmed: 32731171
J Biol Chem. 2000 Mar 31;275(13):9604-11
pubmed: 10734111
Oncol Rep. 2019 Jun;41(6):3404-3412
pubmed: 31002372
PLoS One. 2017 Aug 2;12(8):e0180541
pubmed: 28767654
Toxicol Appl Pharmacol. 2016 Aug 1;304:59-69
pubmed: 27236003
Nature. 1999 Apr 8;398(6727):518-22
pubmed: 10206645
Acta Neuropathol. 2007 Aug;114(2):97-109
pubmed: 17618441
Stem Cells. 2007 Oct;25(10):2524-33
pubmed: 17628016
J Bone Miner Res. 2008 Apr;23(4):525-35
pubmed: 18072873
Front Oncol. 2021 Feb 05;10:574012
pubmed: 33614476
J Surg Res. 2015 Aug;197(2):247-55
pubmed: 25998182
Cancer Res. 2011 Dec 1;71(23):7280-90
pubmed: 21990322
J Clin Oncol. 2012 Jul 1;30(19):2307-13
pubmed: 22547604
PLoS One. 2015 Mar 16;10(3):e0116390
pubmed: 25775002
Biochim Biophys Acta. 1988 Oct 6;944(2):249-55
pubmed: 3179289
Front Oncol. 2015 Mar 03;5:55
pubmed: 25785247
Neuron. 1999 Jan;22(1):103-14
pubmed: 10027293
Stem Cells. 2014 Jan;32(1):301-12
pubmed: 24038660
Cancers (Basel). 2021 Apr 09;13(8):
pubmed: 33918704
Acta Pharm Sin B. 2022 Apr;12(4):1781-1804
pubmed: 35847506
Cells. 2020 Oct 15;9(10):
pubmed: 33076453
Genome Biol. 2020 Jun 9;21(1):127
pubmed: 32513296
Biomolecules. 2021 Dec 13;11(12):
pubmed: 34944514
Cancer Cell. 2014 Nov 10;26(5):605-22
pubmed: 25517747
J Neurooncol. 2006 May;78(1):85-90
pubmed: 16391896
Cancer Res. 2004 Oct 15;64(20):7596-603
pubmed: 15492287
Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11717-22
pubmed: 22753465
Neoplasia. 2014 Jul;16(7):543-61
pubmed: 25117977
J Clin Oncol. 2012 Jul 1;30(19):2348-53
pubmed: 22529266
South Asian J Cancer. 2018 Jul-Sep;7(3):159-162
pubmed: 30112328
J Exp Clin Cancer Res. 2010 Aug 17;29:113
pubmed: 20716331
Cancer Cell. 2013 Mar 18;23(3):390-405
pubmed: 23434461
Nat Rev Clin Oncol. 2021 Mar;18(3):170-186
pubmed: 33293629
Front Cell Neurosci. 2013 Jun 04;7:87
pubmed: 23761735
Invest New Drugs. 2020 Oct;38(5):1570-1579
pubmed: 32140889
Cell. 2006 Mar 10;124(5):973-83
pubmed: 16530044
Cancer Cell. 2018 May 14;33(5):874-889.e7
pubmed: 29681511
Sci Transl Med. 2020 Feb 26;12(532):
pubmed: 32102932
Cancer Res. 2011 Jan 1;71(1):19-28
pubmed: 21199795
Cell Death Differ. 2021 Jan;28(1):15-23
pubmed: 33262470
Neurol Res. 1994 Jun;16(3):184-6
pubmed: 7936086
Development. 2004 Apr;131(8):1663-77
pubmed: 15084453
Biochem Biophys Res Commun. 2015 Aug 7;463(4):638-43
pubmed: 26043698
Cell Biochem Biophys. 2010 Nov;58(2):91-6
pubmed: 20730570
J Exp Clin Cancer Res. 2016 Nov 28;35(1):184
pubmed: 27894350
Nat Genet. 2013 Mar;45(3):253-61
pubmed: 23354438
Infect Agent Cancer. 2019 Oct 18;14:27
pubmed: 31636696
Mol Cell. 2000 Feb;5(2):207-16
pubmed: 10882063
Clin Cancer Res. 2016 Oct 1;22(19):4786-4796
pubmed: 27154916
Mol Cancer Ther. 2016 Nov;15(11):2609-2619
pubmed: 27535971
Mol Med Rep. 2015 Jul;12(1):165-72
pubmed: 25760394
Drug Dev Ind Pharm. 2018 Sep;44(9):1536-1542
pubmed: 29848136
J Exp Clin Cancer Res. 2019 Jan 3;38(1):2
pubmed: 30606241
J Neurosurg. 2011 Oct;115(4):780-8
pubmed: 21721879
Biochim Biophys Acta Mol Cell Res. 2021 Mar;1868(3):118926
pubmed: 33316295
Neuron. 2017 Aug 30;95(5):1056-1073.e5
pubmed: 28803732
J Transl Med. 2012 Sep 03;10:183
pubmed: 22943793
J Cell Sci. 2005 Aug 15;118(Pt 16):3573-84
pubmed: 16105881
Int J Cancer. 2007 Sep 15;121(6):1205-11
pubmed: 17514648
Development. 2011 Sep;138(17):3593-612
pubmed: 21828089
Neuro Oncol. 2017 Oct 19;19(11):1542-1552
pubmed: 28605510
Am J Transl Res. 2020 Aug 15;12(8):4669-4682
pubmed: 32913540
J Neurooncol. 2016 Dec;130(3):571-579
pubmed: 27826680
J Biol Chem. 2008 Dec 19;283(51):35486-95
pubmed: 18948267
Genes Cancer. 2010 Aug;1(8):822-35
pubmed: 21127729
J Thorac Oncol. 2021 Sep;16(9):1547-1558
pubmed: 33607312
Angiogenesis. 2020 Feb;23(1):9-16
pubmed: 31679081
Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4009-14
pubmed: 23412337
J Agric Food Chem. 2014 Jul 30;62(30):7355-62
pubmed: 24754790
Int J Cancer. 2000 May 20;89(3):251-8
pubmed: 10861501
Neuro Oncol. 2018 Jan 10;20(1):37-43
pubmed: 29016805
Stem Cell Reports. 2021 Nov 9;16(11):2589-2606
pubmed: 34653403
Cancer Res. 2021 Jun 15;81(12):3347-3357
pubmed: 33820800
Cancer Treat Rev. 2018 Jan;62:50-60
pubmed: 29169144
Mol Ther Oncolytics. 2017 Oct 24;8:1-13
pubmed: 29234727
Oncol Lett. 2019 Oct;18(4):3646-3654
pubmed: 31579077
Cancer Cell. 2012 Oct 16;22(4):425-37
pubmed: 23079654
Oncol Rep. 2020 May;43(5):1580-1590
pubmed: 32323826
Clin Cancer Res. 2013 Aug 15;19(16):4392-403
pubmed: 23804423
Cell. 2009 Apr 17;137(2):216-33
pubmed: 19379690
J Cell Physiol. 2020 Apr;235(4):3798-3814
pubmed: 31613002
J Biol Chem. 2018 May 25;293(21):8285-8294
pubmed: 29523683
Nat Rev Drug Discov. 2021 Feb;20(2):125-144
pubmed: 33293690
Int J Clin Exp Pathol. 2015 May 01;8(5):5327-35
pubmed: 26191234
Neurosurgery. 2000 Feb;46(2):419-30
pubmed: 10690732
ISRN Mol Biol. 2012 Dec 24;2012:381428
pubmed: 27340590
Science. 2014 Jun 20;344(6190):1396-401
pubmed: 24925914
Oncol Lett. 2017 Sep;14(3):2709-2714
pubmed: 28927033
Sci Rep. 2019 Aug 13;9(1):11724
pubmed: 31409851
Pharmacol Ther. 2015 Feb;146:1-11
pubmed: 25172549
Mol Cell Biol. 2002 Nov;22(22):7812-9
pubmed: 12391150
J Transl Med. 2009 Feb 05;7:13
pubmed: 19196452
Oncotarget. 2016 Nov 22;7(47):78206-78218
pubmed: 27661009
Int J Mol Sci. 2015 Oct 09;16(10):23823-48
pubmed: 26473829
PLoS One. 2015 Mar 12;10(3):e0114830
pubmed: 25763821
Oncologist. 2016 May;21(5):634-42
pubmed: 26984449
J Neurosci Res. 2002 Mar 1;67(5):670-9
pubmed: 11891779
Cancers (Basel). 2011 Aug 10;3(3):3242-78
pubmed: 24212955
Ther Adv Med Oncol. 2010 Jul;2(4):237-50
pubmed: 21789137
J Lipid Res. 2013 Jul;54(7):1761-75
pubmed: 23440512
Curr Opin Genet Dev. 2002 Aug;12(4):478-87
pubmed: 12100896
J Neurosci. 2010 Mar 3;30(9):3489-98
pubmed: 20203209
Oncotarget. 2018 Apr 27;9(32):22703-22716
pubmed: 29854309
Oncol Lett. 2020 Feb;19(2):1247-1254
pubmed: 31966054
Glia. 2011 Aug;59(8):1190-9
pubmed: 21446051
J Neurochem. 2015 Sep;134(5):811-8
pubmed: 25991372
Hum Vaccin Immunother. 2022 Nov 30;18(5):2055417
pubmed: 35344682
Oncotarget. 2015 May 10;6(13):10950-63
pubmed: 25860932
Mol Pharmacol. 2019 Feb;95(2):222-234
pubmed: 30459156
Cell. 2013 Oct 10;155(2):462-77
pubmed: 24120142
Clin Cancer Res. 2019 Feb 15;25(4):1261-1271
pubmed: 30397180
J Biomed Mater Res B Appl Biomater. 2020 Apr;108(3):619-628
pubmed: 31087625
Cancer Cell. 2013 Sep 9;24(3):331-46
pubmed: 23993863
Cold Spring Harb Perspect Biol. 2015 Dec 04;8(3):a018887
pubmed: 26637286
Cancer Res. 2010 Sep 1;70(17):6870-9
pubmed: 20736377
Biomed Res Int. 2019 Apr 17;2019:1321973
pubmed: 31119150
Nat Commun. 2020 Aug 26;11(1):4265
pubmed: 32848154
J Thorac Oncol. 2021 Sep;16(9):1570-1581
pubmed: 33823285
J Neurochem. 2009 Jun;109(6):1779-90
pubmed: 19457135
Science. 2022 Feb 18;375(6582):eabm4459
pubmed: 35175798
Cell Tissue Res. 2017 Dec;370(3):379-390
pubmed: 28815294
Neurochem Res. 2013 Nov;38(11):2313-22
pubmed: 24013885
Australas J Dermatol. 2021 Aug;62(3):394-397
pubmed: 34160825
Anticancer Res. 2009 Jun;29(6):2099-109
pubmed: 19528470
J Cell Physiol. 2019 Mar;234(3):2217-2228
pubmed: 30277583
Oncogene. 2011 Aug 4;30(31):3454-67
pubmed: 21383690
Int J Oncol. 2022 Jun;60(6):
pubmed: 35445737
Sci Rep. 2017 May 19;7(1):2213
pubmed: 28526832
Expert Opin Pharmacother. 2020 Apr;21(5):523-530
pubmed: 32027196
Genes Dev. 2007 Nov 1;21(21):2747-61
pubmed: 17974916
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Oct;33(10):892-7
pubmed: 19001730
Stem Cells. 2010 Jan;28(1):5-16
pubmed: 19904829
Cold Spring Harb Perspect Biol. 2017 Apr 3;9(4):
pubmed: 27920038
Cancer Immunol Immunother. 2007 May;56(5):615-25
pubmed: 16947022
Cancer Cell. 2007 Feb;11(2):147-60
pubmed: 17292826
World J Stem Cells. 2021 Oct 26;13(10):1417-1445
pubmed: 34786152
Apoptosis. 2007 Nov;12(11):2077-87
pubmed: 17701358
Clin Cancer Res. 2009 Nov 1;15(21):6551-9
pubmed: 19861464
Front Oncol. 2021 Sep 09;11:719623
pubmed: 34568049
Lab Invest. 2012 Mar;92(3):466-73
pubmed: 22083670
Biosci Rep. 2018 Aug 29;38(4):
pubmed: 30038061
Front Immunol. 2021 May 13;12:676301
pubmed: 34054867
Nat Commun. 2020 Jun 15;11(1):3015
pubmed: 32541784
Biomed Pharmacother. 2018 Jan;97:667-674
pubmed: 29101811
Mol Cancer Ther. 2010 Jan;9(1):202-10
pubmed: 20053782
Development. 1997 Jul;124(13):2659-70
pubmed: 9217007
Cancer Discov. 2021 Apr;11(4):960-970
pubmed: 33811126
Nat Rev Cancer. 2014 Feb;14(2):77-91
pubmed: 24442143
Proc Natl Acad Sci U S A. 2013 May 21;110(21):8644-9
pubmed: 23650391
Mol Cancer Res. 2020 Jul;18(7):981-991
pubmed: 32234828
Cancer Res. 2005 Mar 15;65(6):2353-63
pubmed: 15781650
Oncotarget. 2016 Jan 19;7(3):3217-32
pubmed: 26673007
Stem Cells. 2014 Aug;32(8):2201-14
pubmed: 24578327
Mol Aspects Med. 2015 Feb;41:1-115
pubmed: 25543955
Cancer Sci. 2012 Oct;103(10):1871-9
pubmed: 22747609
Int J Cancer. 2020 Oct 31;:
pubmed: 33128775
Neuro Oncol. 2019 Jan 1;21(1):59-70
pubmed: 30053126
Genes Dev. 2014 May 15;28(10):1085-100
pubmed: 24788093
Cell. 2019 Aug 8;178(4):835-849.e21
pubmed: 31327527
Front Oncol. 2021 Sep 10;11:687362
pubmed: 34568018
Oncologist. 2013;18(2):163-73
pubmed: 23340005
J Exp Clin Cancer Res. 2022 Jan 25;41(1):35
pubmed: 35078492
Stem Cells. 2010 Jun;28(6):1019-29
pubmed: 20506127
Immunity. 2019 Apr 16;50(4):924-940
pubmed: 30995507
Sci Rep. 2018 Sep 11;8(1):13621
pubmed: 30206363
Bioimpacts. 2017;7(4):269-277
pubmed: 29435435
Heliyon. 2018 May 31;4(5):e00638
pubmed: 29872770
Asian Pac J Cancer Prev. 2015;16(16):6813-23
pubmed: 26514451
Cancer Cell. 2016 Jun 13;29(6):783-803
pubmed: 27300434
Int J Mol Sci. 2021 Aug 05;22(16):
pubmed: 34445128
Toxicol Sci. 2004 Nov;82(1):341-58
pubmed: 15319485
Cancer Cell. 2020 May 11;37(5):630-636
pubmed: 32396858
Curr Oncol. 2012 Dec;19(6):308-14
pubmed: 23300356
Oncotarget. 2017 May 23;8(21):34362-34373
pubmed: 28416766
BMC Cancer. 2011 Feb 22;11:82
pubmed: 21342503
Eur J Cancer. 2001 Mar;37(4):520-30
pubmed: 11267863
Oncogene. 2008 Feb 7;27(7):918-30
pubmed: 17684491
Chin J Nat Med. 2017 Jun;15(6):401-416
pubmed: 28629530
Cancer Res. 1995 Apr 1;55(7):1452-7
pubmed: 7882352
Cancer Res. 2017 Sep 15;77(18):4973-4984
pubmed: 28754668
Int J Mol Sci. 2018 Sep 13;19(9):
pubmed: 30217088
Expert Opin Ther Targets. 2013 Jul;17(7):743-60
pubmed: 23651053
Stem Cells. 2007 Jan;25(1):63-8
pubmed: 16973830
Cell Commun Signal. 2018 Mar 20;16(1):11
pubmed: 29558958
Nat Commun. 2014 Jun 19;5:4196
pubmed: 24943270
Lab Invest. 2017 May;97(5):498-518
pubmed: 28287634
Tohoku J Exp Med. 2010 Aug;221(4):257-64
pubmed: 20622491
Neuro Oncol. 2013 Oct;15(10):1366-78
pubmed: 23787764
Annu Rev Cell Dev Biol. 2004;20:781-810
pubmed: 15473860
Oncogene. 2019 Jan;38(1):120-139
pubmed: 30082911
Genes Dev. 2011 Dec 15;25(24):2594-609
pubmed: 22190458
Biochem Biophys Res Commun. 2017 Mar 18;484(4):833-838
pubmed: 28161636
Anticancer Res. 1998 Sep-Oct;18(5A):3585-9
pubmed: 9858943
Drug Resist Updat. 2021 Mar;55:100753
pubmed: 33667959
Cancer J. 2012 Jan-Feb;18(1):107-14
pubmed: 22290264
Development. 2006 Jan;133(1):3-14
pubmed: 16339192
Oncol Rep. 2015 Dec;34(6):2845-52
pubmed: 26397053
Mol Cell Biol. 2004 Nov;24(21):9265-73
pubmed: 15485896
Cell. 2005 Aug 12;122(3):421-34
pubmed: 16096061
Neuro Oncol. 2019 Dec 17;21(12):1552-1564
pubmed: 31420675
Oncotarget. 2015 Oct 6;6(30):28938-48
pubmed: 26362268
Nat Genet. 2015 May;47(5):458-68
pubmed: 25848751
Genesis. 2018 Feb;56(2):
pubmed: 29330906
Clin Cancer Res. 2010 May 15;16(10):2715-28
pubmed: 20442299
Curr Biol. 1995 Dec 1;5(12):1416-23
pubmed: 8749394
Methods Mol Biol. 2008;469:3-18
pubmed: 19109698
Food Funct. 2020 Aug 1;11(8):7138-7151
pubmed: 32749435
Crit Rev Oncol Hematol. 2014 Sep;91(3):271-82
pubmed: 24793539
Cancer. 2008 Feb 1;112(3):596-607
pubmed: 18098270
Int J Mol Sci. 2021 Jul 20;22(14):
pubmed: 34299349
Clin Cancer Res. 2007 Feb 1;13(3):1045-52
pubmed: 17289901
Genes Dev. 2012 Jun 15;26(12):1300-5
pubmed: 22677547
Curr Cancer Drug Targets. 2013 Jun;13(5):519-41
pubmed: 23597193
Neurosurgery. 2021 Jan 13;88(2):246-251
pubmed: 33027815
Mol Cancer Ther. 2013 Jul;12(7):1180-9
pubmed: 23619303
Cancer Lett. 2010 Jun 1;292(1):64-72
pubmed: 19962820
Nat Rev Mol Cell Biol. 2005 Apr;6(4):306-17
pubmed: 15803137
J Cancer Sci Ther. 2010 Jun 26;2:107-113
pubmed: 21666767
J Biol Chem. 2009 Nov 6;284(45):31018-27
pubmed: 19726682
Nature. 2010 Apr 15;464(7291):1052-7
pubmed: 20393564
Cancers (Basel). 2021 Oct 12;13(20):
pubmed: 34680255
Curr Pharm Biotechnol. 2011 Dec;12(12):2203-13
pubmed: 21619536
J Natl Cancer Inst. 2012 Oct 3;104(19):1458-69
pubmed: 22945948
Anticancer Res. 2010 Dec;30(12):4915-20
pubmed: 21187470
Cancer Res. 2011 Apr 15;71(8):3066-75
pubmed: 21363911
J Neurochem. 2014 Dec;131(6):731-42
pubmed: 25040912
Drug Deliv Transl Res. 2016 Jun;6(3):333-40
pubmed: 26744179
Neuro Oncol. 2004 Jul;6(3):253-8
pubmed: 15279718
Elife. 2015 Jun 08;4:
pubmed: 26051822
Neurooncol Adv. 2019 May-Dec;1(1):vdz042
pubmed: 32309805
Nat Genet. 1995 Dec;11(4):409-14
pubmed: 7493021
Biochem Biophys Res Commun. 2011 Mar 25;406(4):643-8
pubmed: 21371437
Cancer Lett. 2016 Oct 1;380(2):586-597
pubmed: 26639195
Cell Mol Life Sci. 2018 Feb;75(3):385-402
pubmed: 28821904
Cell Death Differ. 2012 Oct;19(10):1644-54
pubmed: 22539003
Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:1267-1280
pubmed: 27987683
Cancer Cell. 2006 Mar;9(3):157-73
pubmed: 16530701
Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2662-2671
pubmed: 30700544
Genes Dis. 2014 Sep;1(1):87-105
pubmed: 25401122
Neurol Clin. 2018 Aug;36(3):485-499
pubmed: 30072067
Lancet Oncol. 2014 Sep;15(10):1100-8
pubmed: 25163906
FEBS J. 2012 Jun;279(12):2247-59
pubmed: 22521131
Jpn J Clin Oncol. 2009 Oct;39(10):625-31
pubmed: 19797419
J Neurooncol. 2021 Feb;151(3):375-391
pubmed: 33611705
Nat Rev Mol Cell Biol. 2015 Feb;16(2):110-23
pubmed: 25560970
Front Pharmacol. 2020 Jun 30;11:984
pubmed: 32695004
Oncogenesis. 2020 Oct 18;9(10):93
pubmed: 33071287
Oncogene. 2012 Apr 12;31(15):1923-37
pubmed: 21874045
Cancer Cell. 2020 Sep 14;38(3):366-379.e8
pubmed: 32649888
Cells. 2019 Apr 29;8(5):
pubmed: 31035664
Neuron. 2011 Mar 10;69(5):840-55
pubmed: 21382546
J Clin Oncol. 2003 Jun 15;21(12):2305-11
pubmed: 12805331
J Cell Biol. 1992 Apr;117(2):395-400
pubmed: 1560032
Mol Cell. 2003 Feb;11(2):377-89
pubmed: 12620226
PLoS One. 2017 Jan 12;12(1):e0169854
pubmed: 28081224
Neuro Oncol. 2016 Aug;18(8):1146-56
pubmed: 26902851
J Exp Med. 2012 Aug 27;209(9):1611-27
pubmed: 22908324
Front Cell Dev Biol. 2022 Jan 03;9:787989
pubmed: 35047500
Development. 2007 Feb;134(4):801-11
pubmed: 17229764
Trends Genet. 1999 Oct;15(10):418-25
pubmed: 10498938
Crit Rev Food Sci Nutr. 2019;59(sup1):S71-S80
pubmed: 30277803
Genes Dev. 2001 Dec 1;15(23):3059-87
pubmed: 11731473
Genes Dev. 2003 May 15;17(10):1207-12
pubmed: 12730124
PLoS One. 2010 Feb 08;5(2):e9094
pubmed: 20161710
Onco Targets Ther. 2022 Apr 28;15:437-468
pubmed: 35509452
Genes Dev. 2016 Jan 1;30(1):1-17
pubmed: 26728553
Plants (Basel). 2021 May 26;10(6):
pubmed: 34073157
Int J Mol Sci. 2019 Aug 05;20(15):
pubmed: 31387280
Dev Psychol. 2009 Jan;45(1):139-50
pubmed: 19209997
J Nutr Metab. 2021 Jun 09;2021:9949453
pubmed: 34221501
Cell Death Differ. 2019 Sep;26(9):1813-1831
pubmed: 30538287
Neuro Oncol. 2015 Oct;17 Suppl 4:iv1-iv62
pubmed: 26511214
Pharmacol Res. 2020 Oct;160:104794
pubmed: 32278038
Cancer Res. 2011 Aug 15;71(16):5374-80
pubmed: 21697283
Front Pharmacol. 2022 Feb 28;13:791272
pubmed: 35295334
Neoplasia. 2011 Jun;13(6):537-49
pubmed: 21677877
J Leukoc Biol. 1996 Jun;59(6):769-74
pubmed: 8691059
J Cancer Res Ther. 2018;14(Supplement):S237-S242
pubmed: 29578180
Sci Transl Med. 2013 Feb 6;5(171):171ra17
pubmed: 23390247
Clin Cancer Res. 2021 Mar 1;27(5):1553-1569
pubmed: 33172899
Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4):
pubmed: 28389444
Cell. 1994 Oct 21;79(2):273-82
pubmed: 7954795
Front Oncol. 2020 Jul 24;10:1233
pubmed: 32793494
Cancer Genet. 2012 Jun;205(6):267-77
pubmed: 22749032
Biomed Pharmacother. 2019 Feb;110:473-481
pubmed: 30530050
Brain Res. 2013 Apr 24;1507:115-24
pubmed: 23466456
Brain. 2010 Jul;133(Pt 7):1961-72
pubmed: 20513660
Cell Death Dis. 2015 Jan 15;6:e1601
pubmed: 25590811
Neuro Oncol. 2012 Aug;14(8):958-78
pubmed: 22573310
Cell. 1997 Jul 25;90(2):281-91
pubmed: 9244302
Pharmaceutics. 2021 Nov 22;13(11):
pubmed: 34834395
Life Sci. 2020 Sep 15;257:118027
pubmed: 32622951
Cell Mol Life Sci. 2008 May;65(9):1311-34
pubmed: 18239854
Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16292-16301
pubmed: 32601208
World J Surg Oncol. 2013 Oct 08;11:264
pubmed: 24099560
Mol Cell. 2000 Feb;5(2):197-206
pubmed: 10882062
Science. 2007 Jun 15;316(5831):1619-22
pubmed: 17569865
J Clin Invest. 2020 Jun 1;130(6):3069-3086
pubmed: 32182224
J Clin Invest. 2011 Jan;121(1):148-60
pubmed: 21183792
Cancers (Basel). 2020 Oct 23;12(11):
pubmed: 33114183
Nat Rev Mol Cell Biol. 2006 Sep;7(9):678-89
pubmed: 16921404
EMBO Rep. 2008 Apr;9(4):377-83
pubmed: 18274550
Science. 2014 Jan 10;343(6167):189-193
pubmed: 24336570
Lancet Oncol. 2017 Jan;18(1):42-51
pubmed: 27932068
Transl Oncol. 2021 Nov;14(11):101192
pubmed: 34365219
Cold Spring Harb Perspect Biol. 2017 Aug 1;9(8):
pubmed: 28130363
Sci Rep. 2020 Jan 28;10(1):1290
pubmed: 31992775
Nature. 1995 Sep 28;377(6547):355-8
pubmed: 7566092
Neuron. 2020 Dec 23;108(6):1130-1145.e5
pubmed: 33086038
N Engl J Med. 2005 Mar 10;352(10):987-96
pubmed: 15758009
Am J Hum Genet. 2000 Nov;67(5):1047-54
pubmed: 11001584
Cell Stem Cell. 2009 Nov 6;5(5):504-14
pubmed: 19896441
J Hematol Oncol. 2020 Dec 4;13(1):165
pubmed: 33276800
Nat Cancer. 2021 Feb;2(2):174-188
pubmed: 33644767
Cell. 2017 Jun 1;169(6):985-999
pubmed: 28575679
Cell. 1996 Nov 15;87(4):661-73
pubmed: 8929535
Genes Dev. 2015 Jun 15;29(12):1203-17
pubmed: 26109046
Oncol Lett. 2018 Jan;15(1):908-916
pubmed: 29422966
Front Oncol. 2021 Jul 08;11:701291
pubmed: 34307170
Neurosurg Focus. 2014 Dec;37(6):E13
pubmed: 25434382