Stem Cells from Healthy and Tendinopathic Human Tendons: Morphology, Collagen and Cytokines Expression and Their Response to T3 Thyroid Hormone.

Achilles Tendon Collagen / metabolism Cytokines / metabolism Humans Stem Cells Triiodothyronine / metabolism
T3 thyroid hormone cytokines tendinopathy tendon stem/progenitor cells type III collagen

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
16 08 2022
Historique:
received: 29 05 2022
revised: 11 08 2022
accepted: 11 08 2022
entrez: 26 8 2022
pubmed: 27 8 2022
medline: 30 8 2022
Statut: epublish

Résumé

The aim of this study was to investigate the effect of triiodothyronine (T3) on tendon specific markers and cytokines expression of stem cells extracted from human tendons. Indeed, thyroid hormones have been reported to be protective factors, maintaining tendons' homeostasis, whereas tendinopathy is believed to be related to a failed healing response. Healthy and tendinopathic human tendons were harvested to isolate tendon stem/progenitor cells (TSPCs). TSPCs obtained from pathological samples showed gene expression and morphological modifications at baseline in comparison with cells harvested from healthy tissues. When cells were maintained in a medium supplemented with T3 (10

Identifiants

DOI: 10.3390/cells11162545 PMID: 36010622 PMC: PMC9406581
pubmed: 36010622
pii: cells11162545
doi: 10.3390/cells11162545
pmc: PMC9406581
pii:
doi:

Substances chimiques

Cytokines 0
Triiodothyronine 06LU7C9H1V
Collagen 9007-34-5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Maria Camilla Ciardulli (MC)

Laboratory of Translational Medicine, Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi, Italy.

Pasqualina Scala (P)

Laboratory of Translational Medicine, Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi, Italy.

Valentina Giudice (V)

Laboratory of Translational Medicine, Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi, Italy.
Hematology and Transplant Center, University Hospital "San Giovanni di Dio e Ruggi D'Aragona", 84131 Salerno, Italy.
ORCID: 0000-0002-7492-6848

Antonietta Santoro (A)

Laboratory of Translational Medicine, Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi, Italy.
ORCID: 0000-0002-2549-5447

Carmine Selleri (C)

Laboratory of Translational Medicine, Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi, Italy.
Hematology and Transplant Center, University Hospital "San Giovanni di Dio e Ruggi D'Aragona", 84131 Salerno, Italy.
ORCID: 0000-0002-5861-8984

Francesco Oliva (F)

Laboratory of Translational Medicine, Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi, Italy.

Nicola Maffulli (N)

Laboratory of Translational Medicine, Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi, Italy.
Centre for Sports and Exercise Medicine, Barts and The London School of Medicine and Dentistry, Mile End Hospital, Queen Mary University of London, 275 Bancroft Road, London E1 4DG, UK.

Giovanna Della Porta (GD)

Laboratory of Translational Medicine, Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi, Italy.
Interdepartment Centre BIONAM, University of Salerno, Via Giovanni Paolo I, 84084 Fisciano, Italy.
ORCID: 0000-0002-1426-0159

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Classifications MeSH

questionsmedicales.fr › Appareil locomoteur › Tendons › Tendon calcanéen › Stem Cells from Healthy and Tendinopathic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Collagène › Stem Cells from Healthy and Tendinopathic...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Stem Cells from Healthy and Tendinopathic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Stem Cells from Healthy and Tendinopathic...
questionsmedicales.fr › Cellules › Cellules souches › Stem Cells from Healthy and Tendinopathic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés cycliques › Acides aminés aromatiques › Thyroxine › Thyronines › Tri-iodothyronine › Stem Cells from Healthy and Tendinopathic...