The Interplay between Telomeres, Mitochondria, and Chronic Stress Exposure in the Aging Egg.
ROS
aging
egg
mitochondria
mitochondrial function
oocyte
oxidative stress
telomere shortening
telomeres
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
22 08 2022
22 08 2022
Historique:
received:
27
06
2022
revised:
26
07
2022
accepted:
20
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
While at the organismal level, biological aging can be estimated by telomere length and DNA methylation signatures, reliable biomarkers that can predict reproductive age are much needed to gauge the quality of an oocyte. Reproductive medicine and fertility centers often merely quantitate the ovarian reserve to predict the likelihood of fertilization and pregnancy in women of advanced reproductive age. It is highly important to address the level of age-related decline in oocyte quality since it leads to an increased risk of miscarriages and aneuploidy. Conversely, the pathways behind oocyte aging remain, in large part, elusive. Telomere shortening upon chronic stress exposure regulates mitochondria function and biogenesis by various pathways; therefore, establishing a link between these two important players and extrapolating them for the aging of oocytes will be the purpose of our commentary.
Identifiants
pubmed: 36010691
pii: cells11162612
doi: 10.3390/cells11162612
pmc: PMC9406770
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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