A Paradoxical Role for Regulatory T Cells in the Tumor Microenvironment of Pancreatic Cancer.
pancreatic ductal adenocarcinoma (PDAC)
prognosis
regulatory T cells (Treg)
tumor infiltrating lymphocytes (TIL)
tumor microenvironment (TME)
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
10 Aug 2022
10 Aug 2022
Historique:
received:
03
07
2022
revised:
18
07
2022
accepted:
05
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
27
8
2022
Statut:
epublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) is considered to be a poorly immunogenic cancer type that combines a low mutation burden with a strong immunosuppressive tumor microenvironment. Regulatory T cells (Tregs) are major drivers of immune suppression but their prognostic role, particularly in gastrointestinal malignancies, remains controversial. Lymphocytic infiltration in 122 PDAC samples was assessed by multispectral immunofluorescence with anti-Keratin, -CD3, -CD8, -FOXP3 and -CD163 antibodies. Differential infiltration by Tregs was analyzed in the context of transcriptomic profiles that were available for 65 tumors. High infiltration of CD3
Identifiants
pubmed: 36010856
pii: cancers14163862
doi: 10.3390/cancers14163862
pmc: PMC9405872
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : European Commission H2020 MSCA-ETN
ID : 675743
Organisme : European Research Council (ERC)
ID : 852832
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