Maternal Microbiota Modulate a Fragile X-like Syndrome in Offspring Mice.
FMRP
FXS
Lactobacillus reuteri
microbiome
probiotic
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
08 08 2022
08 08 2022
Historique:
received:
16
06
2022
revised:
17
07
2022
accepted:
03
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
Maternal microbial dysbiosis has been implicated in adverse postnatal health conditions in offspring, such as obesity, cancer, and neurological disorders. We observed that the progeny of mice fed a Westernized diet (WD) with low fiber and extra fat exhibited higher frequencies of stereotypy, hyperactivity, cranial features and lower FMRP protein expression, similar to what is typically observed in Fragile X Syndrome (FXS) in humans. We hypothesized that gut dysbiosis and inflammation during pregnancy influenced the prenatal uterine environment, leading to abnormal phenotypes in offspring. We found that oral in utero supplementation with a beneficial anti-inflammatory probiotic microbe,
Identifiants
pubmed: 36011319
pii: genes13081409
doi: 10.3390/genes13081409
pmc: PMC9407566
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : T35 OD033655
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA164337
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD024356
Pays : United States
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