Interactome of PTH-Regulated miRNAs and Their Predicted Target Genes for Investigating the Epigenetic Effects of PTH (1-34) in Bone Metabolism.
Cytoscape
biological pathway
gene enrichment biomarker
microRNA
network
osteoporosis
osteoporosis treatment
parathyroid hormone
teriparatide
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
13 08 2022
13 08 2022
Historique:
received:
12
07
2022
revised:
08
08
2022
accepted:
09
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
Osteoporosis is a metabolic bone disease that mostly affects the elderly. A lot of drugs are available, mostly with an antiresorptive effect but just a few with an osteoanabolic effect, meaning they promote bone building. PTH (1-34) or teriparatide is an osteoanabolic drug, but its efficacy varies between individuals. We performed a literature review and extracted a dataset of 62 microRNAs (miRNAs) from 10 different studies; predicted miRNA target interactions (MTIs) were obtained with the help of four software tools: DIANA, miRWalk, miRDB and TargetScan. With the construction of an interactome of PTH-regulated miRNAs and their predicted target genes, we elucidated miR-146a-5p, miR-551b-5p, miR-205-3p, miR-33a-3p, miR-338-5p as miRNAs with the most interactions and miR-410-3p as the miRNA targeting bone-related pathways with the highest significance. These miRNAs could help in further understanding the mechanism of action of PTH on bone metabolism and osteoporosis. They also have the potential for novel network-based biomarkers for osteoporosis treatment efficacy and safety and as new therapeutic targets.
Identifiants
pubmed: 36011354
pii: genes13081443
doi: 10.3390/genes13081443
pmc: PMC9407897
pii:
doi:
Substances chimiques
MIRN338 microRNA, human
0
MIRN410 microRNA, human
0
MicroRNAs
0
PTH protein, human
0
Parathyroid Hormone
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Nucleic Acids Res. 2020 Jan 8;48(D1):D148-D154
pubmed: 31647101
BMC Med Genomics. 2015 Nov 10;8:75
pubmed: 26555194
J Endocrinol Invest. 2015 Jan;38(1):13-29
pubmed: 25194424
Curr Mol Med. 2022;22(6):549-561
pubmed: 34463227
Int J Biol Sci. 2012;8(2):272-88
pubmed: 22298955
Nucleic Acids Res. 2020 Jan 8;48(D1):D127-D131
pubmed: 31504780
Sci Rep. 2018 Mar 1;8(1):3867
pubmed: 29497100
Eur J Rheumatol. 2017 Mar;4(1):46-56
pubmed: 28293453
Biosci Rep. 2019 May 14;39(5):
pubmed: 31023966
J Clin Endocrinol Metab. 2018 Mar 1;103(3):1206-1213
pubmed: 29309589
Mech Dev. 1998 Feb;71(1-2):65-76
pubmed: 9507067
ACS Biomater Sci Eng. 2021 Oct 11;7(10):4933-4945
pubmed: 34583510
Nucleic Acids Res. 2015 Jul 1;43(W1):W460-6
pubmed: 25977294
Physiol Rev. 2012 Jul;92(3):1479-514
pubmed: 22811431
Curr Stem Cell Res Ther. 2006 Jan;1(1):103-11
pubmed: 18220859
Eur Rev Med Pharmacol Sci. 2019 Dec;23(24):11043-11050
pubmed: 31858576
Cell Death Differ. 2016 Jul;23(7):1128-39
pubmed: 26868907
Int J Mol Med. 2018 May;41(5):2535-2544
pubmed: 29484369
Arch Oral Biol. 2019 Apr;100:23-32
pubmed: 30771694
J Cell Physiol. 2020 Nov;235(11):7996-8009
pubmed: 31960421
Biochimie. 2019 Mar;158:43-52
pubmed: 30562548
J Clin Endocrinol Metab. 2020 Aug 1;105(8):
pubmed: 32521543
Development. 2015 Jan 15;142(2):385-93
pubmed: 25564625
J Bone Miner Res. 2012 Oct;27(10):2075-84
pubmed: 22623172
Aging Cell. 2016 Aug;15(4):744-54
pubmed: 27146333
Bone. 2016 Mar;84:181-188
pubmed: 26748295
Bone. 2006 Dec;39(6):1361-72
pubmed: 16904389
Bone Rep. 2021 Mar 15;14:101013
pubmed: 33855130
J Cell Biochem. 2005 May 15;95(2):403-18
pubmed: 15779007
Nucleic Acids Res. 2022 Jan 7;50(D1):D1055-D1061
pubmed: 34469540
J Recept Signal Transduct Res. 2015;35(6):640-5
pubmed: 26390889
Bone. 2020 Feb;131:115104
pubmed: 31683019
Oncol Lett. 2019 Jan;17(1):468-481
pubmed: 30655789
J Allergy Clin Immunol. 2018 Apr;141(4):1202-1207
pubmed: 29074454
Endocr Rev. 1986 Nov;7(4):379-408
pubmed: 3536460
Stem Cell Res Ther. 2022 Mar 28;13(1):130
pubmed: 35346361
Trends Pharmacol Sci. 2014 Mar;35(3):146-54
pubmed: 24439680
Cold Spring Harb Perspect Med. 2018 Aug 1;8(8):
pubmed: 29358318
PLoS One. 2018 Oct 18;13(10):e0206239
pubmed: 30335862
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Int J Mol Sci. 2020 Sep 21;21(18):
pubmed: 32967078
Cell Metab. 2010 Feb 3;11(2):147-60
pubmed: 20142102
Lancet. 2019 Jan 26;393(10169):364-376
pubmed: 30696576
Br Med Bull. 2020 May 15;133(1):105-117
pubmed: 32282039
Acta Biochim Pol. 2022 Jun 6;69(2):371-377
pubmed: 35667086
Front Genet. 2019 Oct 30;10:1044
pubmed: 31737038
Mol Endocrinol. 2015 Oct;29(10):1498-509
pubmed: 26287518
Bone. 2018 Dec;117:98-115
pubmed: 30218791
Annu Rev Med. 2020 Jan 27;71:277-288
pubmed: 31509477
J Cell Biochem. 2018 Jul;119(7):6181-6193
pubmed: 29626351
JCI Insight. 2019 Dec 5;4(23):
pubmed: 31801906
Science. 2019 Dec 20;366(6472):
pubmed: 31806698
J Bone Miner Res. 2021 Jun;36(6):1131-1144
pubmed: 33598975
Arch Biochem Biophys. 2008 May 15;473(2):139-46
pubmed: 18395508
BMJ. 2021 Mar 29;372:n160
pubmed: 33781993
Front Mol Biosci. 2021 May 05;8:593310
pubmed: 34026818
Dev Cell. 2005 May;8(5):727-38
pubmed: 15866163
Nucleic Acids Res. 2013 Jul;41(Web Server issue):W169-73
pubmed: 23680784
Exp Cell Res. 2016 Sep 10;347(1):74-82
pubmed: 27426726
Sci Rep. 2017 Nov 10;7(1):15300
pubmed: 29127344
J Cell Physiol. 2018 Jun;233(6):4606-4617
pubmed: 29219182
Crit Rev Eukaryot Gene Expr. 2009;19(1):1-46
pubmed: 19191755
Bioengineered. 2022 Apr;13(4):11269-11280
pubmed: 35484994