The Role of Inflammation, Hypoxia, and Opioid Receptor Expression in Pain Modulation in Patients Suffering from Obstructive Sleep Apnea.
OSA
hypoxia
inflammation
nociceptors
obstructive sleep apnea
opioids
pain
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 Aug 2022
13 Aug 2022
Historique:
received:
17
07
2022
revised:
08
08
2022
accepted:
11
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
Obstructive sleep apnea (OSA) is a relatively common disease in the general population. Besides its interaction with many comorbidities, it can also interact with potentially painful conditions and modulate its course. The association between OSA and pain modulation has recently been a topic of concern for many scientists. The mechanism underlying OSA-related pain connection has been linked with different pathophysiological changes in OSA and various pain mechanisms. Furthermore, it may cause both chronic and acute pain aggravation as well as potentially influencing the antinociceptive mechanism. Characteristic changes in OSA such as nocturnal hypoxemia, sleep fragmentation, and systemic inflammation are considered to have a curtailing impact on pain perception. Hypoxemia in OSA has been proven to have a significant impact on increased expression of proinflammatory cytokines influencing the hyperalgesic priming of nociceptors. Moreover, hypoxia markers by themselves are hypothesized to modulate intracellular signal transduction in neurons and have an impact on nociceptive sensitization. Pain management in patients with OSA may create problems arousing from alterations in neuropeptide systems and overexpression of opioid receptors in hypoxia conditions, leading to intensification of side effects, e.g., respiratory depression and increased opioid sensitivity for analgesic effects. In this paper, we summarize the current knowledge regarding pain and pain treatment in OSA with a focus on molecular mechanisms leading to nociceptive modulation.
Identifiants
pubmed: 36012341
pii: ijms23169080
doi: 10.3390/ijms23169080
pmc: PMC9409023
pii:
doi:
Substances chimiques
Receptors, Opioid
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education and Science, Poland
ID : SKN/SP/536070/2020
Références
Trends Pharmacol Sci. 2001 Feb;22(2):91-6
pubmed: 11166853
Dis Model Mech. 2013 Jul;6(4):889-95
pubmed: 23828645
J Clin Sleep Med. 2022 Feb 01;18(2):647-652
pubmed: 34672945
Neurobiol Dis. 2010 Oct;40(1):155-62
pubmed: 20553872
Anesth Analg. 2001 Dec;93(6):1495-500, table of contents
pubmed: 11726430
Pain. 2016 Nov;157(11):2420-2423
pubmed: 27200490
Bosn J Basic Med Sci. 2017 Feb 21;17(1):47-53
pubmed: 27754829
J Physiol. 2009 Jun 1;587(Pt 11):2677-92
pubmed: 19403616
Br J Anaesth. 1995 Aug;75(2):125-31
pubmed: 7577246
Biochem Biophys Res Commun. 2006 May 5;343(2):591-6
pubmed: 16554025
Int J Biol Sci. 2012;8(9):1237-47
pubmed: 23136552
Nat Med. 2017 Jun;23(6):768-774
pubmed: 28481358
J Neurobiol. 2004 Oct;61(1):88-106
pubmed: 15362155
Sci Rep. 2017 Mar 16;7:44693
pubmed: 28300223
J Pain. 2009 Sep;10(9):895-926
pubmed: 19712899
Cytokine Growth Factor Rev. 2002 Aug-Oct;13(4-5):413-21
pubmed: 12220554
Cytokine. 1991 May;3(3):189-94
pubmed: 1883957
Bioengineered. 2021 Dec;12(2):10666-10681
pubmed: 34747311
J Neurosci. 2006 Jan 4;26(1):246-55
pubmed: 16399694
N Engl J Med. 1996 Jan 11;334(2):99-104
pubmed: 8531966
J Physiol. 2007 Jul 1;582(Pt 1):11
pubmed: 17525109
Mol Biol Cell. 2010 Jun 15;21(12):2087-96
pubmed: 20427574
Int J Rheum Dis. 2017 Mar;20(3):340-345
pubmed: 26258423
Stroke. 2007 Mar;38(3):1025-30
pubmed: 17272771
Ann Am Thorac Soc. 2020 Oct;17(10):1273-1278
pubmed: 32644865
Int J Mol Sci. 2018 Jul 24;19(8):
pubmed: 30042373
J Neuroimmunol. 2004 Aug;153(1-2):171-82
pubmed: 15265675
Biochem Insights. 2019 Apr 17;12:1178626419842176
pubmed: 31024217
Acta Physiol Scand. 2003 Mar;177(3):385-90
pubmed: 12609010
Dev Neurobiol. 2007 Feb 15;67(3):326-38
pubmed: 17443791
Circulation. 2003 Mar 4;107(8):1129-34
pubmed: 12615790
J Cell Physiol. 2011 Nov;226(11):2925-33
pubmed: 21302291
Protein Cell. 2017 Sep;8(9):644-661
pubmed: 28364279
Brain Behav Immun. 2004 Jul;18(4):298-303
pubmed: 15157946
Sleep. 2018 Jan 1;41(1):
pubmed: 29228393
Am J Respir Crit Care Med. 1996 Jun;153(6 Pt 1):1880-7
pubmed: 8665050
J Neurosci. 2019 Mar 20;39(12):2291-2300
pubmed: 30692228
Anesthesiology. 2018 Aug;129(2):343-366
pubmed: 29462012
Acta Pharmacol Sin. 2012 Jan;33(1):5-10
pubmed: 22212429
Front Immunol. 2020 Jan 28;10:3061
pubmed: 32047493
J Clin Med. 2021 Aug 24;10(17):
pubmed: 34501217
J Clin Sleep Med. 2014 Aug 15;10(8):847-52
pubmed: 25126029
Front Cell Neurosci. 2013 Dec 04;7:236
pubmed: 24363643
Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11344-8
pubmed: 1722327
PLoS One. 2015 May 26;10(5):e0127809
pubmed: 26010491
Biol Pharm Bull. 2011;34(8):1170-3
pubmed: 21804201
Int J Mol Sci. 2021 Nov 21;22(22):
pubmed: 34830418
J Neurosci. 2005 Aug 31;25(35):7986-92
pubmed: 16135755
Mol Endocrinol. 2016 Feb;30(2):201-16
pubmed: 26714229
J Neurosci. 2008 May 14;28(20):5189-94
pubmed: 18480275
Prog Cardiovasc Dis. 2009 Mar-Apr;51(5):392-9
pubmed: 19249445
Cell Immunol. 1993 Sep;150(2):391-404
pubmed: 8396498
Neurosci Lett. 1985 Jun 12;57(2):125-30
pubmed: 2412189
Arthritis Res Ther. 2012 Jul 09;14(4):R162
pubmed: 22776095
Biochemistry. 2010 Feb 9;49(5):835-42
pubmed: 20050630
Curr Pain Headache Rep. 2013 Sep;17(9):361
pubmed: 23943407
PLoS One. 2013;8(1):e54807
pubmed: 23382975
Anesthesiology. 2006 Oct;105(4):715-8
pubmed: 17006070
Antioxid Redox Signal. 2014 Jun 1;20(16):2555-71
pubmed: 24144405
Biochem Biophys Res Commun. 1988 Jul 15;154(1):227-35
pubmed: 2840066
Respir Physiol Neurobiol. 2002 Jul;131(1-2):15-27
pubmed: 12106992
Life Sci. 1993;53(5):397-405
pubmed: 8336518
Lancet Respir Med. 2019 Aug;7(8):687-698
pubmed: 31300334
BMC Neurosci. 2013 Oct 31;14:132
pubmed: 24175938
Sleep. 2011 Dec 01;34(12):1687-91
pubmed: 22131606
Sleep. 2006 Feb;29(2):145-51
pubmed: 16494081
Int J Mol Sci. 2019 Jan 22;20(3):
pubmed: 30678164
Circulation. 2005 Oct 25;112(17):2660-7
pubmed: 16246965
Physiol Rev. 2014 Oct;94(4):1099-142
pubmed: 25287861
Arch Intern Med. 2006 Sep 18;166(16):1756-62
pubmed: 16983055
Sci Signal. 2014 Oct 07;7(346):ra94
pubmed: 25292213
Am J Addict. 2016 Sep;25(6):452-65
pubmed: 27554389
Int J Mol Sci. 2020 Dec 29;22(1):
pubmed: 33383924
Sleep Breath. 2014 Sep;18(3):571-7
pubmed: 24515853
J Appl Physiol (1985). 1992 Dec;73(6):2462-9
pubmed: 1490959
Proc Am Thorac Soc. 2008 Feb 15;5(2):144-53
pubmed: 18250206
Nat Rev Rheumatol. 2016 Jan;12(1):49-62
pubmed: 26656660
Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):648-52
pubmed: 1731336
Pol Arch Intern Med. 2020 Feb 27;130(2):158-160
pubmed: 31834288
J Clin Med. 2021 Dec 27;11(1):
pubmed: 35011878
Trends Neurosci. 2003 Dec;26(12):696-705
pubmed: 14624855
Rheumatology (Oxford). 2018 Mar 1;57(3):429-440
pubmed: 28968842
Nat Med. 2010 Nov;16(11):1248-57
pubmed: 20948530
Int J Mol Sci. 2022 Jan 10;23(2):
pubmed: 35054894
Endocrinology. 1999 Jul;140(7):3082-90
pubmed: 10385400
Pain. 2001 Jan;89(2-3):265-73
pubmed: 11166483
Front Physiol. 2020 Sep 09;11:1035
pubmed: 33013447
Sleep. 2007 Sep;30(9):1145-52
pubmed: 17910386
J Clin Med. 2021 Dec 23;11(1):
pubmed: 35011807
BMC Pulm Med. 2022 Mar 18;22(1):94
pubmed: 35303833
Neuron. 2019 Feb 6;101(3):353-355
pubmed: 30731054
J Clin Sleep Med. 2013 Oct 15;9(10):1003-12
pubmed: 24127144
Pain. 2009 Dec 15;147(1-3):265-76
pubmed: 19853381
Int Anesthesiol Clin. 2007 Spring;45(2):27-37
pubmed: 17426506
J Neural Transm (Vienna). 2009 Oct;116(10):1221-5
pubmed: 19565181
Brain Res. 1997 Sep 19;769(1):97-107
pubmed: 9374277
Hypertension. 2001 Feb;37(2 Pt 2):728-32
pubmed: 11230364
Chin Med J (Engl). 2014;127(1):43-7
pubmed: 24384422
J Clin Sleep Med. 2020 Oct 15;16(10):1761-1768
pubmed: 32663129
Exp Neurol. 2014 Nov;261:354-66
pubmed: 24910202
Hypertension. 1998 Dec;32(6):1039-43
pubmed: 9856970
Sleep Breath. 2015 May;19(2):561-8
pubmed: 25108706
J Clin Med. 2020 May 25;9(5):
pubmed: 32466207
Cell Tissue Res. 2019 Jan;375(1):227-241
pubmed: 30284083
Sleep Med Rev. 2021 Aug;58:101441
pubmed: 33567395
Cell Mol Neurobiol. 2018 Apr;38(3):579-593
pubmed: 28623429
Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10188-93
pubmed: 9707622
Arthritis Res Ther. 2014;16(5):470
pubmed: 25606597
J Biol Chem. 2012 Sep 14;287(38):31962-72
pubmed: 22843691
Mol Psychiatry. 2019 Apr;24(4):576-587
pubmed: 29955162
Br J Pharmacol. 2012 May;166(2):510-21
pubmed: 22233379
Neuroscience. 1996 Mar;71(2):523-31
pubmed: 9053804
Brain Res Bull. 2003 Jan 15;59(4):307-13
pubmed: 12464404
Eur J Neurosci. 2003 May;17(9):1847-52
pubmed: 12752784
Clin Plast Surg. 2020 Apr;47(2):173-180
pubmed: 32115044
J Neurophysiol. 2004 Nov;92(5):2859-66
pubmed: 15486424
Neurogastroenterol Motil. 2021 Jun;33(6):e13978
pubmed: 32869433
J Sleep Res. 2020 Aug;29(4):e12995
pubmed: 32166825
Anesth Analg. 2003 Apr;96(4):1096-1103
pubmed: 12651667
J Neurosci. 1996 Aug 1;16(15):4742-8
pubmed: 8764661
J Clin Endocrinol Metab. 1999 Aug;84(8):2603-7
pubmed: 10443646
J Clin Sleep Med. 2018 Jan 15;14(1):153
pubmed: 29198299
Nat Rev Dis Primers. 2017 Feb 16;3:17002
pubmed: 28205574
Anesthesiology. 2004 Apr;100(4):806-10; discussion 5A
pubmed: 15087614
Cells. 2019 May 04;8(5):
pubmed: 31060230
Front Immunol. 2020 Jul 21;11:1343
pubmed: 32793188
J Physiol. 2007 Jun 15;581(Pt 3):1193-205
pubmed: 17395627
Lancet Respir Med. 2015 Apr;3(4):310-8
pubmed: 25682233
Front Neurol. 2018 Aug 03;9:635
pubmed: 30123179
J Neurosci. 2012 Jul 25;32(30):10136-45
pubmed: 22836249
Eur J Pharmacol. 2001 Oct 19;429(1-3):79-91
pubmed: 11698029
Pathol Biol (Paris). 2014 Oct;62(5):233-40
pubmed: 25070768
Pain. 2015 Jun;156(6):1124-1144
pubmed: 25775359
Dis Markers. 2021 Oct 4;2021:1219593
pubmed: 34646401
Anesthesiology. 2013 Nov;119(5):1149-62
pubmed: 24025612
Pain Med. 2018 Sep 1;19(suppl_1):S69-S75
pubmed: 30203008