Vitamin D-Related Genetic Variations and Nonalcoholic Fatty Liver Disease: A Systematic Review.
CYP24A1
CYP27B1
CYP2R1
DHCR7
GC
VDR
genetic variation
nonalcoholic fatty liver disease
nonalcoholic steatohepatitis
polymorphism
systematic review
vitamin D
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Aug 2022
14 Aug 2022
Historique:
received:
07
07
2022
revised:
12
08
2022
accepted:
12
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
Studies have demonstrated the link between vitamin-D-related genetic variations and nonskeletal outcomes. We aimed to identify all available data on the association of vitamin-D-related genetic variations with nonalcoholic fatty liver disease (NAFLD). Potentially eligible studies were identified from Embase and Medline databases from inception to June 2022 using a search strategy that comprised terms for "Vitamin D" and "NAFLD". Eligible studies must report the association between vitamin D-related genetic variations and presence, severity or response to treatment of NAFLD. Data were extracted from each eligible study. A total of 3495 articles were identified. After a systematic review, twelve studies were included. A total of 26 genetic variations were identified. Presence of NAFLD was associated with variations of Multiple vitamin D-related genetic variations were associated with NAFLD, indicating the role of vitamin D in the pathogenesis of NAFLD.
Sections du résumé
BACKGROUND
BACKGROUND
Studies have demonstrated the link between vitamin-D-related genetic variations and nonskeletal outcomes. We aimed to identify all available data on the association of vitamin-D-related genetic variations with nonalcoholic fatty liver disease (NAFLD).
METHODS
METHODS
Potentially eligible studies were identified from Embase and Medline databases from inception to June 2022 using a search strategy that comprised terms for "Vitamin D" and "NAFLD". Eligible studies must report the association between vitamin D-related genetic variations and presence, severity or response to treatment of NAFLD. Data were extracted from each eligible study.
RESULTS
RESULTS
A total of 3495 articles were identified. After a systematic review, twelve studies were included. A total of 26 genetic variations were identified. Presence of NAFLD was associated with variations of
CONCLUSIONS
CONCLUSIONS
Multiple vitamin D-related genetic variations were associated with NAFLD, indicating the role of vitamin D in the pathogenesis of NAFLD.
Identifiants
pubmed: 36012386
pii: ijms23169122
doi: 10.3390/ijms23169122
pmc: PMC9409408
pii:
doi:
Substances chimiques
Receptors, Calcitriol
0
Vitamins
0
Vitamin D
1406-16-2
Cytochrome P450 Family 2
EC 1.14.14.1
Cholestanetriol 26-Monooxygenase
EC 1.14.15.15
Vitamin D3 24-Hydroxylase
EC 1.14.15.16
Types de publication
Journal Article
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
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