MYRF: A New Regulator of Cardiac and Early Gonadal Development-Insights from Single Cell RNA Sequencing Analysis.

CITED2 MYRF cardiac and urogenital syndrome disorders of sex development gonadal development scimitar syndrome

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
18 Aug 2022
Historique:
received: 30 06 2022
revised: 16 08 2022
accepted: 17 08 2022
entrez: 26 8 2022
pubmed: 27 8 2022
medline: 27 8 2022
Statut: epublish

Résumé

De novo variants in the myelin regulatory factor (MYRF), a transcription factor involved in the differentiation of oligodendrocytes, have been linked recently to the cardiac and urogenital syndrome, while familiar variants are associated with nanophthalmos. Here, we report for the first time on a patient with a de novo stop-gain variant in

Identifiants

pubmed: 36013096
pii: jcm11164858
doi: 10.3390/jcm11164858
pmc: PMC9409872
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Federal Ministry of Education and Research
ID : 01DQ17004
Organisme : Deutsche Forschungsgemeinschaft
ID : EXC 22167- 390884018
Organisme : Federal Ministry of Health
ID : 2519FSB503
Organisme : São Paulo Research Foundation
ID : 2020/13421-8
Organisme : Alexander von Humboldt Foundation
ID : HFS
Organisme : German Academic Exchange Service
ID : 57460069

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Verónica Calonga-Solís (V)

Division of Paediatric Endocrinology and Diabetes, Department of Paediatric and Adolescent Medicine, University of Lübeck, 23562 Lübeck, Germany.
Medical Systems Biology Division, Lübeck Institute of Experimental Dermatology, University of Lübeck, 23562 Lübeck, Germany.

Helena Fabbri-Scallet (H)

Division of Paediatric Endocrinology and Diabetes, Department of Paediatric and Adolescent Medicine, University of Lübeck, 23562 Lübeck, Germany.
Center for Molecular Biology and Genetic Engineering-CBMEG, State University of Campinas, Campinas 13083-875, Brazil.

Fabian Ott (F)

Medical Systems Biology Division, Lübeck Institute of Experimental Dermatology, University of Lübeck, 23562 Lübeck, Germany.

Mostafa Al-Sharkawi (M)

Division of Paediatric Endocrinology and Diabetes, Department of Paediatric and Adolescent Medicine, University of Lübeck, 23562 Lübeck, Germany.
Biochemical Genetics Department, Human Genetics and Genome Research Institute, National Research Centre, Dokki, Cairo 12622, Egypt.

Axel Künstner (A)

Medical Systems Biology Division, Lübeck Institute of Experimental Dermatology, University of Lübeck, 23562 Lübeck, Germany.

Lutz Wünsch (L)

Department of Pediatric Surgery, University of Lübeck, 23562 Lübeck, Germany.

Olaf Hiort (O)

Division of Paediatric Endocrinology and Diabetes, Department of Paediatric and Adolescent Medicine, University of Lübeck, 23562 Lübeck, Germany.

Hauke Busch (H)

Medical Systems Biology Division, Lübeck Institute of Experimental Dermatology, University of Lübeck, 23562 Lübeck, Germany.

Ralf Werner (R)

Division of Paediatric Endocrinology and Diabetes, Department of Paediatric and Adolescent Medicine, University of Lübeck, 23562 Lübeck, Germany.
Institute of Molecular Medicine, University of Lübeck, 23562 Lübeck, Germany.

Classifications MeSH