The Role of Angiotensin Receptor Blockers in the Personalized Management of Diabetic Neuropathy.
angiotensin receptor blockers
diabetes mellitus
diabetic neuropathy
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
30 Jul 2022
30 Jul 2022
Historique:
received:
27
06
2022
revised:
27
07
2022
accepted:
29
07
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
27
8
2022
Statut:
epublish
Résumé
Neuropathy is a frequent complication of diabetes mellitus (DM) and is associated with the increased risk ofamputation and vascular events. Tight glycemic control is an important component inthe prevention of diabetic neuropathy. However, accumulating data suggest that angiotensin receptor blockers (ARBs) might also be useful in this setting. We discuss the findings of both experimental and clinical studies that evaluated the effects of ARBs on indices of diabetic neuropathy. We also review the implicated mechanisms of the neuroprotective actions of these agents. Overall, it appears that ARBs might be a helpful tool for preventing and delaying the progression of diabetic neuropathy, but more data are needed to clarify their role in the management of this overlooked complication of DM.
Identifiants
pubmed: 36013202
pii: jpm12081253
doi: 10.3390/jpm12081253
pmc: PMC9410471
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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