Wnt/β-Catenin-Pathway Alterations and Homologous Recombination Deficiency in Cholangiocarcinoma Cell Lines and Clinical Samples: Towards Specific Vulnerabilities.
APC
HRD
Olaparib
PARP
WNT
cholangiocarcinoma
intraductal papillary neoplasm of the bile duct
β-catenin
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
01 Aug 2022
01 Aug 2022
Historique:
received:
17
06
2022
revised:
20
07
2022
accepted:
29
07
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
27
8
2022
Statut:
epublish
Résumé
Cholangiocarcinoma (CCA) features a dismal prognosis with limited treatment options. Genomic studies have unveiled several promising targets in this disease, including fibroblast growth factor receptor (FGFR) fusions and isocitrate dehydrogenase (IDH) mutations. To fully harness the potential of genomically informed therapies in CCA, it is necessary to thoroughly characterize the available model organisms, including cell lines. One parameter to investigate in CCA is homologous recombination deficiency (HRD). While mutations in homologous recombinational repair (HRR)-related genes have been detected, their predictive value remains undetermined. Using a targeted next-generation sequencing approach, we analyzed 12 human CCA cell lines and compared them to 62 CCA samples of the molecular tumor board cohort. The AmoyDx
Identifiants
pubmed: 36013219
pii: jpm12081270
doi: 10.3390/jpm12081270
pmc: PMC9410222
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
J Clin Invest. 2012 Aug;122(8):2911-5
pubmed: 22797301
Oncogene. 2003 Sep 1;22(37):5792-812
pubmed: 12947387
Cancer Discov. 2014 May;4(5):546-53
pubmed: 24625776
PLoS One. 2018 Jan 19;13(1):e0191593
pubmed: 29352306
Nat Cell Biol. 2008 Feb;10(2):160-9
pubmed: 18193033
Breast Cancer Res Treat. 2014 Sep;147(2):401-5
pubmed: 25129345
Biochem J. 2009 Sep 25;423(2):157-68
pubmed: 19772495
Genes Chromosomes Cancer. 2015 Jun;54(6):361-8
pubmed: 25899310
Cells. 2022 Apr 26;11(9):
pubmed: 35563769
Mod Pathol. 2014 Jan;27(1):73-86
pubmed: 23828315
Chin Clin Oncol. 2020 Feb;9(1):6
pubmed: 32075397
Exp Mol Med. 2020 Feb;52(2):183-191
pubmed: 32037398
Hum Pathol. 2019 Nov;93:65-73
pubmed: 31430493
iScience. 2019 Nov 22;21:624-637
pubmed: 31731200
Lancet Oncol. 2019 May;20(5):636-648
pubmed: 30948273
Cancer Discov. 2016 Feb;6(2):147-153
pubmed: 26644315
Cancers (Basel). 2019 Jul 02;11(7):
pubmed: 31269694
Oncogene. 2018 Jun;37(24):3229-3242
pubmed: 29545603
JCO Precis Oncol. 2018;2018:
pubmed: 30234181
Nat Rev Clin Oncol. 2018 Feb;15(2):95-111
pubmed: 28994423
Oncogene. 2021 May;40(21):3637-3654
pubmed: 33941852
J Hepatol. 2019 Oct;71(4):742-752
pubmed: 31195063
Br J Cancer. 2019 Aug;121(4):332-339
pubmed: 31312030
Nature. 2019 Mar;567(7749):521-524
pubmed: 30867592
J Clin Invest. 2015 Mar 2;125(3):1269-85
pubmed: 25689248
Lung Cancer. 2021 Jul;157:21-29
pubmed: 34052705
Cold Spring Harb Perspect Biol. 2017 Jan 3;9(1):
pubmed: 27836834
JAMA Oncol. 2021 Nov 01;7(11):1669-1677
pubmed: 34554208
Front Immunol. 2021 May 20;12:658097
pubmed: 34093545
Cell. 1990 Jun 1;61(5):759-67
pubmed: 2188735
Onco Targets Ther. 2018 Sep 18;11:5957-5962
pubmed: 30271179
Nat Genet. 2017 Feb;49(2):180-185
pubmed: 28067913
Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12649-54
pubmed: 23847203
Mod Pathol. 2001 Sep;14(9):900-5
pubmed: 11557787
Lancet Oncol. 2020 May;21(5):671-684
pubmed: 32203698
Molecules. 2020 Aug 18;25(16):
pubmed: 32824685
Cancer Discov. 2012 May;2(5):401-4
pubmed: 22588877
J Biol Chem. 2008 Nov 28;283(48):33053-8
pubmed: 18838381
N Engl J Med. 2019 Jul 25;381(4):317-327
pubmed: 31157963
Int J Radiat Oncol Biol Phys. 2015 Oct 1;93(2):281-93
pubmed: 26383678
Drugs. 2020 Jun;80(9):923-929
pubmed: 32472305
N Engl J Med. 2018 Dec 27;379(26):2495-2505
pubmed: 30345884
Expert Opin Ther Targets. 2017 May;21(5):471-483
pubmed: 28326864
Gastroenterology. 2022 Aug;163(2):481-494
pubmed: 35489428
Nat Rev Cancer. 2005 Sep;5(9):689-98
pubmed: 16110319
Onco Targets Ther. 2020 Jul 01;13:6385-6391
pubmed: 32753881
Sci Signal. 2013 Apr 02;6(269):pl1
pubmed: 23550210
Ann Oncol. 2019 Apr 1;30(4):558-566
pubmed: 30689707
N Engl J Med. 2020 May 28;382(22):2091-2102
pubmed: 32343890
J Hepatol. 2022 May;76(5):1109-1121
pubmed: 35167909
Cancer Discov. 2022 Jan;12(1):31-46
pubmed: 35022204
J Natl Cancer Inst. 2018 Jul 1;110(7):704-713
pubmed: 29788099
Am J Surg Pathol. 2018 Dec;42(12):1674-1685
pubmed: 30212390
Biosci Rep. 2020 Mar 27;40(3):
pubmed: 32140709
Eur J Cancer. 2019 Oct;120:31-39
pubmed: 31476489
Epigenetics Chromatin. 2021 Jan 19;14(1):8
pubmed: 33468217
Mol Cell Biol. 2002 Feb;22(4):1172-83
pubmed: 11809808