Mechanisms Linking COPD to Type 1 and 2 Diabetes Mellitus: Is There a Relationship between Diabetes and COPD?
chronic obstructive pulmonary disease
diabetes
hyperglycemia
inflammation
insulin
metabolism
oxidative stress
Journal
Medicina (Kaunas, Lithuania)
ISSN: 1648-9144
Titre abrégé: Medicina (Kaunas)
Pays: Switzerland
ID NLM: 9425208
Informations de publication
Date de publication:
01 Aug 2022
01 Aug 2022
Historique:
received:
24
06
2022
revised:
25
07
2022
accepted:
27
07
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
Chronic obstructive pulmonary disease (COPD) patients frequently suffer from multiple comorbidities, resulting in poor outcomes for these patients. Diabetes is observed at a higher frequency in COPD patients than in the general population. Both type 1 and 2 diabetes mellitus are associated with pulmonary complications, and similar therapeutic strategies are proposed to treat these conditions. Epidemiological studies and disease models have increased our knowledge of these clinical associations. Several recent genome-wide association studies have identified positive genetic correlations between lung function and obesity, possibly due to alterations in genes linked to cell proliferation; embryo, skeletal, and tissue development; and regulation of gene expression. These studies suggest that genetic predisposition, in addition to weight gain, can influence lung function. Cigarette smoke exposure can also influence the differential methylation of CpG sites in genes linked to diabetes and COPD, and smoke-related single nucleotide polymorphisms are associated with resting heart rate and coronary artery disease. Despite the vast literature on clinical disease association, little direct mechanistic evidence is currently available demonstrating that either disease influences the progression of the other, but common pharmacological approaches could slow the progression of these diseases. Here, we review the clinical and scientific literature to discuss whether mechanisms beyond preexisting conditions, lifestyle, and weight gain contribute to the development of COPD associated with diabetes. Specifically, we outline environmental and genetic confounders linked with these diseases.
Identifiants
pubmed: 36013497
pii: medicina58081030
doi: 10.3390/medicina58081030
pmc: PMC9415273
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL148774
Pays : United States
Références
J Surg Res. 1999 Apr;82(2):234-43
pubmed: 10090835
Diabetes Care. 2004 Mar;27(3):752-7
pubmed: 14988297
Exerc Sport Sci Rev. 2010 Jul;38(3):105-13
pubmed: 20577058
Sci Rep. 2020 Jan 27;10(1):1242
pubmed: 31988353
Eur J Clin Invest. 1999 Feb;29(2):145-52
pubmed: 10093001
PLoS One. 2020 Feb 6;15(2):e0228279
pubmed: 32027677
PLoS One. 2019 May 21;14(5):e0214622
pubmed: 31112544
Diabetes Res Clin Pract. 2018 Aug;142:46-55
pubmed: 29802957
ERJ Open Res. 2021 Oct 11;7(4):
pubmed: 34765673
Physiol Rev. 2011 Jan;91(1):79-118
pubmed: 21248163
Diabetologia. 2009 Aug;52(8):1665-8
pubmed: 19455302
PLoS One. 2017 Apr 14;12(4):e0175794
pubmed: 28410410
Ann Intern Med. 2016 Jun 7;164(11):740-51
pubmed: 27088241
Diabetes Metab. 2019 Apr;45(2):184-190
pubmed: 29804817
Eur Respir J. 2010 Feb;35(2):317-23
pubmed: 19574332
Diabetes Care. 2004 Oct;27(10):2478-84
pubmed: 15451919
Nutrients. 2019 Jun 16;11(6):
pubmed: 31208151
Eur Respir J. 2009 May;33(5):1165-85
pubmed: 19407051
J Korean Med Sci. 2010 Oct;25(10):1480-6
pubmed: 20890430
Diabetes Care. 2014 Feb;37(2):389-95
pubmed: 24026562
Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10305-10
pubmed: 24982147
Am J Epidemiol. 2010 Apr 1;171(7):776-84
pubmed: 20172921
J Cell Mol Med. 2016 Apr;20(4):758-64
pubmed: 26837005
Int J Mol Sci. 2021 Jun 22;22(13):
pubmed: 34206324
Transplantation. 2007 Mar 15;83(5):566-9
pubmed: 17353775
Am J Respir Crit Care Med. 2015 Aug 1;192(3):295-306
pubmed: 26020495
J Clin Endocrinol Metab. 2014 Aug;99(8):E1418-26
pubmed: 24527714
J Clin Endocrinol Metab. 1997 Nov;82(11):3619-24
pubmed: 9360516
J Clin Invest. 2005 Aug;115(8):2069-72
pubmed: 16075050
Diabetes Care. 2008 Aug;31(8):1596-601
pubmed: 18492945
Diabetes. 2007 Nov;56(11):2790-6
pubmed: 17686944
Int J Chron Obstruct Pulmon Dis. 2018 Oct 15;13:3331-3340
pubmed: 30410322
Islets. 2010 May-Jun;2(3):185-9
pubmed: 21099312
Int J Chron Obstruct Pulmon Dis. 2018 Mar 02;13:771-780
pubmed: 29535517
Diabetes Care. 2008 Apr;31(4):741-6
pubmed: 18056886
J Pers Med. 2021 Sep 30;11(10):
pubmed: 34683134
Eur Respir J. 2021 Oct 14;58(4):
pubmed: 33766948
Int J Obes Relat Metab Disord. 2004 Aug;28(8):993-7
pubmed: 15211360
Ann Epidemiol. 1997 Feb;7(2):81-6
pubmed: 9099395
Virchows Arch A Pathol Anat Histol. 1981;390(3):313-24
pubmed: 6269272
Hippokratia. 2016 Apr-Jun;20(2):110-114
pubmed: 28416906
Br J Clin Pharmacol. 2002 Jul;54(1):59-64
pubmed: 12100226
Mol Neurobiol. 2019 May;56(5):3079-3089
pubmed: 30094805
Respir Res. 2014 Nov 27;15:151
pubmed: 25427655
Int J Chron Obstruct Pulmon Dis. 2012;7:571-6
pubmed: 23055707
Radiology. 2011 Oct;261(1):274-82
pubmed: 21788524
J Allergy Clin Immunol. 2016 Jul;138(1):16-27
pubmed: 27373322
Respiration. 1999;66(1):14-9
pubmed: 9973685
Clin Biochem. 2007 Aug;40(12):843-50
pubmed: 17509552
Lancet. 2015 Jul 25;386(9991):360-8
pubmed: 26026936
Diabetes Care. 2019 Apr;42(4):617-624
pubmed: 30705064
Am J Physiol Lung Cell Mol Physiol. 2014 Jan 1;306(1):L43-9
pubmed: 24097557
Am J Med. 2010 Nov;123(11):1001-6
pubmed: 20870201
Pharmacol Ther. 2017 Dec;180:139-143
pubmed: 28648831
Am J Respir Crit Care Med. 2010 May 1;181(9):917-27
pubmed: 20133931
Circulation. 2009 Oct 20;120(16):1640-5
pubmed: 19805654
Respiration. 2010;80(2):112-9
pubmed: 20134148
Am J Physiol Regul Integr Comp Physiol. 2015 Nov 1;309(9):R1144-52
pubmed: 26377563
Am J Respir Crit Care Med. 1995 May;151(5):1551-8
pubmed: 7735614
Respirology. 2019 Jul;24(7):646-651
pubmed: 30761687
Thorax. 2016 Jul;71(7):587-93
pubmed: 26917577
Clin Transl Med. 2022 Jun;12(6):e902
pubmed: 35678098
PLoS One. 2017 Oct 24;12(10):e0186708
pubmed: 29065130
J Clin Endocrinol Metab. 2008 Feb;93(2):578-83
pubmed: 18029454
Respir Res. 2019 Apr 5;20(1):69
pubmed: 30953517
Inflamm Allergy Drug Targets. 2011 Jun;10(3):208-17
pubmed: 21495968
J Surg Res. 1991 Apr;50(4):308-13
pubmed: 2020184
Toxicol Lett. 2004 Dec 1;154(1-2):1-9
pubmed: 15475173
Chest. 2006 Mar;129(3):762-70
pubmed: 16537879
Diabetes. 2001 Dec;50(12):2792-808
pubmed: 11723063
Nat Med. 2005 May;11(5):491-8
pubmed: 15852018
Curr Diab Rep. 2016 Nov;16(11):107
pubmed: 27664040
J Surg Res. 1977 Mar;22(3):221-7
pubmed: 14280
Clin Sci (Lond). 2004 May;106(5):527-33
pubmed: 14678009
Diabetologia. 1992 Dec;35(12):1140-5
pubmed: 1478365
PLoS One. 2014 Feb 28;9(2):e90567
pubmed: 24587397
Am Rev Respir Dis. 1987 Jan;135(1):223-9
pubmed: 3492160
Diabetes. 2003 Jan;52(1):1-8
pubmed: 12502486
J Dermatol Sci. 1998 Jan;16(2):144-51
pubmed: 9459127
Sci Rep. 2020 Sep 8;10(1):14790
pubmed: 32901098
Intern Emerg Med. 2014 Jun;9(4):419-25
pubmed: 23645508
Metabolism. 2011 Feb;60(2):256-9
pubmed: 20153491
Free Radic Biol Med. 2011 Mar 1;50(5):567-75
pubmed: 21163346
Oncotarget. 2017 Apr 4;8(14):22513-22523
pubmed: 28186975
J Immunol. 2005 Jan 1;174(1):131-42
pubmed: 15611235
Life Sci. 1975 Sep 15;17(6):921-5
pubmed: 127912
PLoS One. 2016 Sep 22;11(9):e0162903
pubmed: 27658209
Pediatr Diabetes. 2018 Aug;19(5):945-954
pubmed: 29473705
Cell Biochem Biophys. 2014 Nov;70(2):1385-91
pubmed: 24938900
Chest. 2009 Oct;136(4):1039-1046
pubmed: 19542257
Am Rev Respir Dis. 1987 Oct;136(4):941-6
pubmed: 3662244
Acta Diabetol. 2012 Apr;49(2):159-64
pubmed: 22105342
Respiration. 2015;89(3):253-64
pubmed: 25677307
Am J Physiol Endocrinol Metab. 2013 Apr 15;304(8):E810-8
pubmed: 23403945
Curr Respir Care Rep. 2013 Sep 1;2(3):
pubmed: 24187653
BMC Endocr Disord. 2019 Jan 3;19(1):2
pubmed: 30606177
Am J Epidemiol. 2014 Jan 1;179(1):48-56
pubmed: 24064740
Thorax. 2017 Jun;72(6):500-509
pubmed: 28228486
Can Respir J. 2012 May-Jun;19(3):e18-24
pubmed: 22679617
Int J Chron Obstruct Pulmon Dis. 2011;6:199-208
pubmed: 21660297
In Vivo. 2018 Jul-Aug;32(4):753-758
pubmed: 29936455
PLoS One. 2014 Jun 20;9(6):e98013
pubmed: 24950070
Int J Chron Obstruct Pulmon Dis. 2021 Nov 24;16:3189-3199
pubmed: 34853511
PLoS One. 2017 May 15;12(5):e0177501
pubmed: 28505167
Am J Respir Crit Care Med. 2009 Jun 1;179(11):1011-21
pubmed: 19264974
Am J Respir Crit Care Med. 2001 May;163(6):1476-83
pubmed: 11371421
Nat Med. 2011 Feb;17(2):179-88
pubmed: 21217695
Pharmacol Rev. 2012 Apr;64(2):337-58
pubmed: 22407613
Wound Repair Regen. 2013 Jul-Aug;21(4):545-53
pubmed: 23627689
J Surg Res. 1996 Feb 15;61(1):113-9
pubmed: 8769952
Am J Respir Crit Care Med. 2015 Feb 1;191(3):275-84
pubmed: 25494452
Sci Rep. 2022 Jan 26;12(1):1435
pubmed: 35082306
Int J Mol Sci. 2019 Nov 29;20(23):
pubmed: 31795482
Eur Respir J. 2004 Jul;24(1):18-23
pubmed: 15293600
Endocrinology. 2001 Mar;142(3):1269-77
pubmed: 11181544
Hypertension. 2006 Jun;47(6):1183-8
pubmed: 16636195
COPD. 2014 Apr;11(2):133-42
pubmed: 23848509
Thorax. 2009 Oct;64(10):857-62
pubmed: 19454410
Diabetologia. 1992 Dec;35(12):1173-6
pubmed: 1478371
J Thorac Dis. 2019 Oct;11(10):4371-4378
pubmed: 31737323
Int J Obes Relat Metab Disord. 1997 Jan;21(1):50-3
pubmed: 9023601
J Appl Physiol (1985). 2010 Mar;108(3):722-8
pubmed: 19875709
Respirology. 2016 May;21(4):590-9
pubmed: 26852737
Am J Physiol Lung Cell Mol Physiol. 2018 Feb 1;314(2):L298-L317
pubmed: 29025711
J Diabetes Investig. 2015 Nov;6(6):600-9
pubmed: 26543531
Int J Mol Sci. 2019 May 17;20(10):
pubmed: 31108840
Am Rev Respir Dis. 1988 Jan;137(1):162-6
pubmed: 3337458
Stroke. 2001 Oct;32(10):2426-32
pubmed: 11588337
Am J Respir Cell Mol Biol. 2012 Oct;47(4):509-16
pubmed: 22652200
J Clin Invest. 1981 Jul;68(1):13-20
pubmed: 7251857
Respir Med. 2005 Jan;99(1):70-4
pubmed: 15672852
Thorax. 2005 Apr;60(4):293-300
pubmed: 15790984
Lancet. 2004 Nov 6-12;364(9446):1645-7
pubmed: 15530607
Am J Med. 1997 Dec;103(6):504-13
pubmed: 9428834
Chest. 2012 Oct;142(4):893-899
pubmed: 22207678
Chest. 2000 Apr;117(4):960-7
pubmed: 10767225
Thorax. 2005 Sep;60(9):761-4
pubmed: 16135681
Respir Physiol Neurobiol. 2007 Dec 15;159(3):331-7
pubmed: 17369109
Int J Chron Obstruct Pulmon Dis. 2015 Aug 10;10:1591-7
pubmed: 26300638
Clin Immunol. 2009 Apr;131(1):11-23
pubmed: 19185542
Chest. 2002 Feb;121(2):443-51
pubmed: 11834655
Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):611-7
pubmed: 16385087
Am J Respir Cell Mol Biol. 2016 Dec;55(6):804-814
pubmed: 27447052
Int J Med Sci. 2014 May 21;11(8):758-64
pubmed: 24936137
Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):369-73
pubmed: 10934055
Am Rev Respir Dis. 1976 Jan;113(1):37-41
pubmed: 1247213
Am J Respir Crit Care Med. 2003 Mar 15;167(6):911-6
pubmed: 12623860
Am J Clin Nutr. 2011 Dec;94(6):1504-12
pubmed: 22071714
Clin Biochem. 2001 Jun;34(4):265-70
pubmed: 11440725
EBioMedicine. 2015 Apr 11;2(6):499-512
pubmed: 26288815
Respir Med. 2013 Sep;107(9):1376-84
pubmed: 23791463
Lipids Health Dis. 2020 Jun 3;19(1):122
pubmed: 32493486
Endocrinology. 1977 Jun;100(6):1710-22
pubmed: 140046
Respir Res. 2021 Apr 27;22(1):127
pubmed: 33906653
BMC Public Health. 2007 Aug 29;7:220
pubmed: 17727697
Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12153-8
pubmed: 16093309
Tanaffos. 2013;12(3):53-7
pubmed: 25191474
Cell. 1995 Dec 1;83(5):803-12
pubmed: 8521497
Am J Respir Crit Care Med. 2014 Jul 15;190(2):155-64
pubmed: 24871890
Surgery. 1997 May;121(5):513-9
pubmed: 9142149
Sci Rep. 2018 Aug 9;8(1):11920
pubmed: 30093732
Pediatr Diabetes. 2016 Aug;17(5):351-9
pubmed: 26073583
Nat Genet. 2017 Mar;49(3):426-432
pubmed: 28166215
Int J Clin Exp Pathol. 2015 Oct 01;8(10):13209-16
pubmed: 26722520
Mol Metab. 2020 Jul;37:100975
pubmed: 32283079
J Allergy Clin Immunol. 2020 Feb;145(2):537-549
pubmed: 31669095
J Bras Pneumol. 2009 Aug;35(8):788-91
pubmed: 19750332
Biol Chem. 2015 Jun;396(6-7):749-58
pubmed: 25781540
Respir Res. 2006 Apr 10;7:64
pubmed: 16606450
Arch Surg. 2003 Jan;138(1):34-40
pubmed: 12511146
Am J Respir Crit Care Med. 2021 Sep 15;204(6):651-666
pubmed: 34033525
Diabetes Care. 2016 Jan;39 Suppl 1:S6-12
pubmed: 26696683
J Clin Invest. 2005 May;115(5):1111-9
pubmed: 15864338
Diabetes Res. 1986 Nov;3(9):443-5
pubmed: 3030608
J Transl Med. 2009 Mar 17;7:17
pubmed: 19292913
Am J Respir Crit Care Med. 2006 Jun 1;173(11):1222-8
pubmed: 16514110
Thorax. 2019 Apr;74(4):337-345
pubmed: 30630893
Cell Physiol Biochem. 2017;42(5):2093-2104
pubmed: 28810254
Thorax. 1984 Jul;39(7):529-34
pubmed: 6431627
Respiration. 1999;66(1):20-4
pubmed: 9973686
Int J Exp Pathol. 2011 Dec;92(6):392-9
pubmed: 21950537
Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15596-601
pubmed: 12429856
J Immunol. 2018 Jan 15;200(2):623-631
pubmed: 29246951
Respir Res. 2011 Jun 10;12:78
pubmed: 21663649
BMC Pulm Med. 2014 Oct 24;14:164
pubmed: 25341556
Am J Respir Crit Care Med. 2011 Oct 1;184(7):796-802
pubmed: 21965015
J Atheroscler Thromb. 2010 Apr 30;17(4):423-30
pubmed: 20065611
Respir Res. 2019 Jul 30;20(1):171
pubmed: 31362724
Int J Epidemiol. 2018 Dec 1;47(6):1897-1909
pubmed: 30239739
Chron Respir Dis. 2021 Jan-Dec;18:14799731211056348
pubmed: 34797178
Thromb Haemost. 2000 Aug;84(2):210-5
pubmed: 10959691
Eur Respir J. 2014 Feb;43(2):409-20
pubmed: 23794466
Respir Med. 2012 Nov;106(11):1487-93
pubmed: 22902134
Thorax. 2013 Sep;68(9):835-45
pubmed: 23709760
Obesity (Silver Spring). 2011 Feb;19(2):396-401
pubmed: 20829805
Respir Res. 2019 Apr 2;20(1):64
pubmed: 30940143
Chest. 2013 May;143(5):1302-1311
pubmed: 23117188
Chest. 2000 Sep;118(3):656-64
pubmed: 10988186
Eur Respir J. 2005 Sep;26(3):398-405
pubmed: 16135719
Medicina (Kaunas). 2021 Apr 20;57(4):
pubmed: 33923873
Am J Clin Nutr. 2012 Sep;96(3):516-26
pubmed: 22811442
Diabetes Res Clin Pract. 2010 Mar;87(3):385-93
pubmed: 19923032
J Intern Med. 2012 Mar;271(3):305-14
pubmed: 21883537
Eur J Clin Nutr. 2006 Aug;60(8):991-9
pubmed: 16482071
Cardiovasc Diabetol. 2019 Jul 30;18(1):96
pubmed: 31362743
Hum Genet. 2010 Nov;128(5):491-9
pubmed: 20725741
Curr Diabetes Rev. 2020;16(5):442-449
pubmed: 31657690
J Pharm Biomed Anal. 2020 Feb 20;180:113078
pubmed: 31911286
Sci Rep. 2020 Jun 24;10(1):10298
pubmed: 32581289
Diabetes. 2007 May;56(5):1316-23
pubmed: 17360983
Am J Respir Crit Care Med. 2008 Aug 1;178(3):248-60
pubmed: 18467512
Am J Respir Crit Care Med. 2020 Mar 15;201(6):735-739
pubmed: 31751151
Asia Pac J Clin Nutr. 2010;19(4):572-7
pubmed: 21147720
Diabetologia. 2016 May;59(5):998-1006
pubmed: 26825526
Diabetes Metab Res Rev. 2008 Jan-Feb;24(1):14-26
pubmed: 17990280
J Soc Biol. 2001;195(4):391-8
pubmed: 11938556
Thorax. 2007 Dec;62(12):1064-8
pubmed: 17604302
Diabet Med. 2008 Nov;25(11):1370-3
pubmed: 19046232
Eur Respir J. 1997 Aug;10(8):1850-8
pubmed: 9272930
Eur Respir J. 2010 May;35(5):1039-47
pubmed: 19897561
Diabetes. 2015 Oct;64(10):3614-26
pubmed: 26130764
Diabetes. 2006 May;55(5):1436-42
pubmed: 16644702
Thorax. 2004 Jul;59(7):574-80
pubmed: 15223864
Arch Gerontol Geriatr. 2016 May-Jun;64:75-81
pubmed: 26952380
Eur J Clin Nutr. 2014 Feb;68(2):159-65
pubmed: 24327123