Pregnancy and COVID-19: The Possible Contribution of Vitamin D.
SARS-CoV-2
VDR
biomarkers
genetic polymorphisms
newborn
vitamin D
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
10 Aug 2022
10 Aug 2022
Historique:
received:
15
07
2022
revised:
08
08
2022
accepted:
09
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
Vitamin D deficiency has been associated with the severity of COVID-19. The role of vitamin D in pregnant women with COVID-19 has been poorly investigated to date. The aim of this study was to evaluate the influence of vitamin D in affecting some clinical features in pregnancy between SARS-CoV-2 positive and negative patients. Vitamin D pathway related polymorphisms and 25-hydroxyvitamin D levels were quantified in pregnant women followed from the first to the third trimester of pregnancy. Vitamin D deficiency was considered with values ≤ 30 ng/mL. In total, 160 women were enrolled: 23 resulted positive for at least one SARS-CoV-2 related test (molecular swab or antibody tests). Vitamin D-associated polymorphisms were able to affect vitamin D levels in SARS-CoV-2 negative and positive subjects: remarkably, all the This is the first study demonstrating a role of vitamin D in affecting the clinical characteristics of pregnant women during the COVID-19 era. Further studies in larger and different cohorts of patients are required to confirm these findings.
Sections du résumé
BACKGROUND
BACKGROUND
Vitamin D deficiency has been associated with the severity of COVID-19. The role of vitamin D in pregnant women with COVID-19 has been poorly investigated to date. The aim of this study was to evaluate the influence of vitamin D in affecting some clinical features in pregnancy between SARS-CoV-2 positive and negative patients.
METHODS
METHODS
Vitamin D pathway related polymorphisms and 25-hydroxyvitamin D levels were quantified in pregnant women followed from the first to the third trimester of pregnancy. Vitamin D deficiency was considered with values ≤ 30 ng/mL.
RESULTS
RESULTS
In total, 160 women were enrolled: 23 resulted positive for at least one SARS-CoV-2 related test (molecular swab or antibody tests). Vitamin D-associated polymorphisms were able to affect vitamin D levels in SARS-CoV-2 negative and positive subjects: remarkably, all the
CONCLUSIONS
CONCLUSIONS
This is the first study demonstrating a role of vitamin D in affecting the clinical characteristics of pregnant women during the COVID-19 era. Further studies in larger and different cohorts of patients are required to confirm these findings.
Identifiants
pubmed: 36014781
pii: nu14163275
doi: 10.3390/nu14163275
pmc: PMC9414046
pii:
doi:
Substances chimiques
Vitamin D
1406-16-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no potential conflict of interest.
Références
J Obstet Gynaecol Res. 2017 Feb;43(2):247-256
pubmed: 28150405
PLoS One. 2017 Jul 24;12(7):e0180483
pubmed: 28738090
J Med Virol. 2022 May;94(5):2167-2173
pubmed: 35060637
Virchows Arch. 2021 Oct;479(4):715-728
pubmed: 33934229
Mol Hum Reprod. 2020 Jun 1;26(6):367-373
pubmed: 32365180
Trends Immunol. 2020 Dec;41(12):1100-1115
pubmed: 33132005
Medicine (Baltimore). 2021 Jun 18;100(24):e26303
pubmed: 34128867
Am J Respir Crit Care Med. 2004 Nov 1;170(9):967-73
pubmed: 15282199
Clin Calcium. 2015 Nov;25(11):1613-8
pubmed: 26503864
Front Cell Infect Microbiol. 2020 Nov 25;10:587269
pubmed: 33324574
Am J Physiol Renal Physiol. 2005 Jul;289(1):F8-28
pubmed: 15951480
JBMR Plus. 2020 Sep 15;5(1):e10405
pubmed: 32904944
Mol Cell Biochem. 2021 Jun;476(6):2421-2427
pubmed: 33604809
J Med Virol. 2021 Sep;93(9):5285-5294
pubmed: 33990955
PLoS Pathog. 2020 Sep 18;16(9):e1008874
pubmed: 32946517
Physiol Rev. 2021 Jan 1;101(1):303-318
pubmed: 32969772
J Steroid Biochem Mol Biol. 2021 Oct;213:105964
pubmed: 34390830
Nat Commun. 2022 Jan 18;13(1):320
pubmed: 35042863
JAMA Netw Open. 2022 Jun 1;5(6):e2215787
pubmed: 35679048
J Matern Fetal Neonatal Med. 2021 Nov 23;:1-6
pubmed: 34812699
J Steroid Biochem Mol Biol. 2020 Sep;202:105719
pubmed: 32535032
Arch Gynecol Obstet. 2020 Sep;302(3):629-634
pubmed: 32572616
J Med Virol. 2021 Jan;93(1):250-256
pubmed: 32592501
Fertil Steril. 2014 Aug;102(2):460-468.e3
pubmed: 24933120
Int J Hematol. 2021 Jan;113(1):45-57
pubmed: 33161508