The Effects of Swine Coronaviruses on ER Stress, Autophagy, Apoptosis, and Alterations in Cell Morphology.
ER stress
UPR
apoptosis
autophagy
coronaviruses
cytoskeletal rearrangement
epithelial-mesenchymal transition
tight junction proteins
Journal
Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317
Informations de publication
Date de publication:
19 Aug 2022
19 Aug 2022
Historique:
received:
22
07
2022
revised:
14
08
2022
accepted:
15
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
27
8
2022
Statut:
epublish
Résumé
Swine coronaviruses include the following six members, namely porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), porcine delta coronavirus (PDCoV), swine acute diarrhea syndrome coronavirus (SADS-CoV), porcine hemagglutinating encephalomyelitis virus (PHEV), and porcine respiratory coronavirus (PRCV). Clinically, PEDV, TGEV, PDCoV, and SADS-CoV cause enteritis, whereas PHEV induces encephalomyelitis, and PRCV causes respiratory disease. Years of studies reveal that swine coronaviruses replicate in the cellular cytoplasm exerting a wide variety of effects on cells. Some of these effects are particularly pertinent to cell pathology, including endoplasmic reticulum (ER) stress, unfolded protein response (UPR), autophagy, and apoptosis. In addition, swine coronaviruses are able to induce cellular changes, such as cytoskeletal rearrangement, alterations of junctional complexes, and epithelial-mesenchymal transition (EMT), that render enterocytes unable to absorb nutrients normally, resulting in the loss of water, ions, and protein into the intestinal lumen. This review aims to describe the cellular changes in swine coronavirus-infected cells and to aid in understanding the pathogenesis of swine coronavirus infections. This review also explores how the virus exerted subcellular and molecular changes culminating in the clinical and pathological findings observed in the field.
Identifiants
pubmed: 36015060
pii: pathogens11080940
doi: 10.3390/pathogens11080940
pmc: PMC9416022
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Mol Cell Proteomics. 2018 Feb;17(2):190-204
pubmed: 29217619
Biochem Biophys Res Commun. 2014 Mar 7;445(2):497-503
pubmed: 24548406
Virology. 2021 Jan 2;552:43-51
pubmed: 33059319
Vet Microbiol. 2019 May;232:1-12
pubmed: 31030832
Cell Death Differ. 1999 Jun;6(6):516-24
pubmed: 10381654
Vet Microbiol. 2019 Aug;235:209-219
pubmed: 31383304
Int J Cell Biol. 2010;2010:830307
pubmed: 20169136
Vet Microbiol. 2021 Feb;253:108959
pubmed: 33360915
Am J Physiol Gastrointest Liver Physiol. 2001 Jul;281(1):G216-28
pubmed: 11408275
J Virol. 1998 Jun;72(6):4918-24
pubmed: 9573259
Viruses. 2017 Sep 05;9(9):
pubmed: 28872588
Front Microbiol. 2020 Jan 21;10:3085
pubmed: 32038538
Cell Death Differ. 2004 Apr;11(4):372-80
pubmed: 14765132
Virology. 2014 Jul;460-461:180-93
pubmed: 25010284
J Comp Pathol. 2000 Jul;123(1):64-6
pubmed: 10906258
J Virol. 2022 Jan 12;96(1):e0169521
pubmed: 34643429
Autophagy. 2009 Aug;5(6):824-34
pubmed: 19556857
J Vet Med Sci. 2018 Nov 23;80(11):1775-1781
pubmed: 30249935
Virol J. 2018 Nov 7;15(1):170
pubmed: 30404647
Virulence. 2021 Dec;12(1):615-629
pubmed: 33538234
Virus Res. 2015 Mar 16;200:56-63
pubmed: 25533531
Proteomics. 2015 Jun;15(11):1819-28
pubmed: 25604190
Sci Rep. 2019 Feb 4;9(1):1307
pubmed: 30718724
Virus Res. 2014 Dec 19;194:110-23
pubmed: 25304691
Mol Neurobiol. 2020 Dec;57(12):5299-5306
pubmed: 32876841
Virology. 2019 Jan 15;527:89-97
pubmed: 30471453
Viruses. 2019 May 18;11(5):
pubmed: 31109068
Acta Virol. 2015 Sep;59(3):265-75
pubmed: 26435150
Vet Res. 2019 Dec 21;50(1):111
pubmed: 31864417
Vet Microbiol. 2020 May;244:108684
pubmed: 32402351
J Virol. 2019 Feb 19;93(5):
pubmed: 30541856
Biochem Biophys Res Commun. 2013 Dec 6;442(1-2):33-7
pubmed: 24225120
Biol Pharm Bull. 2010;33(4):545-9
pubmed: 20410583
Microb Pathog. 2018 Apr;117:247-254
pubmed: 29408315
Toxicol Pathol. 2007 Jun;35(4):495-516
pubmed: 17562483
Vet Microbiol. 2018 Dec;227:61-68
pubmed: 30473353
Res Vet Sci. 2018 Aug;119:109-115
pubmed: 29909129
Oncotarget. 2016 Mar 15;7(11):12206-21
pubmed: 26933809
J Vet Med Sci. 2009 May;71(5):595-601
pubmed: 19498285
Int J Biol Sci. 2019 Jul 25;15(10):2051-2064
pubmed: 31592229
Virol Sin. 2019 Apr;34(2):175-191
pubmed: 31037644
Nature. 2018 Apr;556(7700):255-258
pubmed: 29618817
Cell Host Microbe. 2020 Dec 9;28(6):853-866.e5
pubmed: 33245857
Virology. 2021 Jul;559:196-209
pubmed: 33964685
J Gen Virol. 2005 Aug;86(Pt 8):2255-2267
pubmed: 16033973
J Virol. 2021 Apr 12;95(9):
pubmed: 33568512
Vet Microbiol. 2017 Nov;211:58-66
pubmed: 29102122
Vet Microbiol. 2021 Apr;255:109015
pubmed: 33640682
Virus Res. 2018 Jul 15;253:112-123
pubmed: 29940190
Virol J. 2013 Jan 19;10:26
pubmed: 23332027
Virus Res. 2020 Aug;285:198024
pubmed: 32482591
Can J Comp Med. 1973 Apr;37(2):177-88
pubmed: 4266698
Vet Microbiol. 2019 Jun;233:147-153
pubmed: 31176401
Antiviral Res. 2017 Oct;146:86-95
pubmed: 28842266
Virus Res. 2020 Aug;285:198026
pubmed: 32482590
Vet Pathol. 2022 Jan;59(1):82-90
pubmed: 34763602
Viruses. 2019 Nov 05;11(11):
pubmed: 31694296
Vet Microbiol. 2013 Jun 28;164(3-4):212-21
pubmed: 23562137
Viruses. 2021 Feb 13;13(2):
pubmed: 33668405
Pol J Vet Sci. 2019 Jun;22(2):345-353
pubmed: 31269354
Vet Microbiol. 2017 Nov;211:15-21
pubmed: 29102111
J Gen Virol. 2020 Sep;101(9):925-940
pubmed: 32568027
Virus Res. 2012 Feb;163(2):628-35
pubmed: 22248641
Cell. 2001 Dec 28;107(7):881-91
pubmed: 11779464
Vet Microbiol. 2021 Jun;257:109068
pubmed: 33894664
Virology. 2019 Jan 15;527:169-179
pubmed: 30530223
J Proteome Res. 2014 Dec 5;13(12):5376-90
pubmed: 25357264
Virus Res. 2016 Dec 2;226:50-59
pubmed: 27086031
J Proteomics. 2016 Jan 01;130:65-75
pubmed: 26361011
Virus Res. 2014 Nov 4;192:34-45
pubmed: 25173696
Viral Immunol. 2021 Jul-Aug;34(6):401-409
pubmed: 33973805
Proteome Sci. 2013 Jul 16;11(1):31
pubmed: 23855489
Viruses. 2021 Apr 14;13(4):
pubmed: 33919952
Vet Microbiol. 2022 Aug;271:109494
pubmed: 35752087
Front Immunol. 2021 Jun 14;12:663303
pubmed: 34194429
Vet Microbiol. 2019 Feb;229:159-167
pubmed: 30642593
Nat Rev Mol Cell Biol. 2014 Mar;15(3):178-96
pubmed: 24556840
Nat Med. 2005 Jul;11(7):725-30
pubmed: 16015365
PLoS Pathog. 2011 Jun;7(6):e1002090
pubmed: 21695242
J Proteome Res. 2020 Nov 6;19(11):4470-4485
pubmed: 33045833
Cell. 2006 Feb 24;124(4):741-54
pubmed: 16497585
Virus Res. 2015 Oct 2;208:136-45
pubmed: 26103099
J Virol. 2018 Oct 29;92(22):
pubmed: 30185587
Tissue Barriers. 2022 Jul 3;10(3):2000300
pubmed: 34740309
Arch Virol. 2020 Nov;165(11):2737-2748
pubmed: 32816125
J Pathol. 2010 May;221(1):3-12
pubmed: 20225336
Vet Res. 2017 Aug 30;48(1):44
pubmed: 28854955
J Virol. 2017 Nov 14;91(23):
pubmed: 28956766
Sci Rep. 2021 Jan 21;11(1):1868
pubmed: 33479333
J Gen Virol. 2013 Aug;94(Pt 8):1807-1817
pubmed: 23677787
Mol Cell Proteomics. 2019 Jan;18(1):51-64
pubmed: 30257878
Viruses. 2020 Feb 14;12(2):
pubmed: 32075094
ACS Omega. 2020 Aug 27;5(35):21979-21987
pubmed: 32923756
Microb Cell. 2020 May 04;7(5):119-128
pubmed: 32391393
J Virol. 2008 Jul;82(14):6962-71
pubmed: 18448518
Exp Mol Med. 2018 Aug 16;50(8):1-9
pubmed: 30115904
Vet Microbiol. 2012 Jul 6;158(1-2):12-22
pubmed: 22341312
Autophagy. 2011 Nov;7(11):1335-47
pubmed: 21799305
Endocr J. 2011;58(5):409-20
pubmed: 21490406
Cell Host Microbe. 2014 Feb 12;15(2):228-38
pubmed: 24528868
Virus Res. 2013 Dec 26;178(2):241-51
pubmed: 24095767
Antiviral Res. 2014 Jun;106:33-41
pubmed: 24681123
Front Cell Infect Microbiol. 2017 Feb 28;7:56
pubmed: 28293544
J Virol. 2017 Oct 13;91(21):
pubmed: 28794036
Protein Cell. 2014 Dec;5(12):912-27
pubmed: 25311841
Viruses. 2021 Jun 24;13(7):
pubmed: 34202551
Microb Pathog. 2020 Oct;147:104378
pubmed: 32653434
Dig Dis Sci. 2018 Nov;63(11):2898-2909
pubmed: 30097894
Arch Virol. 2020 Feb;165(2):345-354
pubmed: 31834525
PLoS Pathog. 2014 Jun 26;10(6):e1004198
pubmed: 24968145
J Biol Chem. 2004 Mar 12;279(11):10136-41
pubmed: 14699140
PeerJ. 2016 Feb 04;4:e1635
pubmed: 26870610
Sci Rep. 2016 Mar 31;6:23864
pubmed: 27029407
Cold Spring Harb Perspect Biol. 2012 Feb 01;4(2):
pubmed: 22300978
Virus Res. 2013 Sep;176(1-2):292-7
pubmed: 23770152
Virus Genes. 2021 Apr;57(2):181-193
pubmed: 33620696
Emerg Microbes Infect. 2020 Dec;9(1):439-456
pubmed: 32090691
Front Cell Infect Microbiol. 2017 Feb 01;7:21
pubmed: 28203548
Cell. 2020 May 28;181(5):1036-1045.e9
pubmed: 32416070
Front Vet Sci. 2020 Aug 13;7:492
pubmed: 32903570
Arch Virol. 2019 Jan;164(1):83-90
pubmed: 30284628
J Virol. 2018 Jul 17;92(15):
pubmed: 29769338
Virus Res. 2016 Aug 15;222:1-12
pubmed: 27215486
J Microbiol Biotechnol. 2019 Nov 28;29(11):1817-1829
pubmed: 31546302
J Virol. 2000 May;74(9):3975-83
pubmed: 10756009
Vet Microbiol. 2018 Jul;221:49-58
pubmed: 29981708
Cell Host Microbe. 2012 Nov 15;12(5):645-56
pubmed: 23159054
J Proteome Res. 2017 Jun 2;16(6):2113-2120
pubmed: 28506058
J Virol. 2021 Sep 9;95(19):e0085121
pubmed: 34287052
Signal Transduct Target Ther. 2020 Oct 9;5(1):235
pubmed: 33037188
Viruses. 2017 Mar 19;9(3):
pubmed: 28335505
Acta Virol. 2018;62(1):41-49
pubmed: 29521102
Cell. 2017 Feb 9;168(4):692-706
pubmed: 28187289
Mol Cell Biol. 2006 Dec;26(24):9220-31
pubmed: 17030611
Nat Rev Mol Cell Biol. 2007 Jul;8(7):519-29
pubmed: 17565364
Oncotarget. 2016 May 10;7(19):27122-41
pubmed: 27027356
Vet Microbiol. 2019 Sep;236:108392
pubmed: 31500725
Antimicrob Agents Chemother. 2015 Feb;59(2):1088-99
pubmed: 25487801
Annu Rev Pathol. 2015;10:173-94
pubmed: 25387057
Arch Virol. 1998;143(12):2471-85
pubmed: 9930203
Vet Res. 2021 Jun 14;52(1):86
pubmed: 34127062
Vet Microbiol. 2016;182:57-63
pubmed: 26711029
PLoS One. 2009 Dec 17;4(12):e8342
pubmed: 20020050
Virus Res. 2021 Apr 15;296:198350
pubmed: 33626380