Therapeutic Drug Monitoring of Sputum Voriconazole in Pulmonary Aspergillosis.
pulmonary aspergillosis
sputum
therapeutic drug monitoring
trough concentration
voriconazole
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
30 Jul 2022
30 Jul 2022
Historique:
received:
18
05
2022
revised:
25
07
2022
accepted:
28
07
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
27
8
2022
Statut:
epublish
Résumé
Voriconazole is one of the most used antifungal azoles against pulmonary aspergillosis. Therapeutic drug monitoring (TDM) of the voriconazole concentration in plasma is recommended in clinical practice guidelines to prevent treatment failure and toxicity. The aim of this study was to evaluate the feasibility and utility of TDM of the voriconazole concentration in the sputum of patients treated for pulmonary aspergillosis. Fifty sputum and 31 plasma samples were analysed with high-performance tandem mass spectrometry (HPLC-MS/MS) in 24 patients included in the study. The voriconazole concentration was simultaneously assessed in the plasma and sputum in 22 samples. The correlation between the sputum and plasma levels was estimated with a univariate linear regression model, and the observed R
Identifiants
pubmed: 36015224
pii: pharmaceutics14081598
doi: 10.3390/pharmaceutics14081598
pmc: PMC9414625
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Fundam Clin Pharmacol. 2019 Apr;33(2):232-238
pubmed: 30306637
Clin Microbiol Infect. 2020 Nov;26(11):1464-1472
pubmed: 32562861
Clin Microbiol Rev. 2014 Jan;27(1):68-88
pubmed: 24396137
Infection. 2017 Dec;45(6):737-779
pubmed: 28702763
Clin Pharmacol Ther. 2018 Feb;103(2):185-186
pubmed: 28786228
Clin Infect Dis. 2008 Jan 15;46(2):201-11
pubmed: 18171251
Antimicrob Agents Chemother. 2011 Feb;55(2):925-8
pubmed: 21078931
Int J Infect Dis. 2011 Nov;15(11):e753-8
pubmed: 21831685
J Clin Med. 2021 May 13;10(10):
pubmed: 34068031
Lancet Infect Dis. 2021 Jun;21(6):e149-e162
pubmed: 33333012
Int J Antimicrob Agents. 2016 Feb;47(2):124-31
pubmed: 26775563
Antimicrob Agents Chemother. 2006 May;50(5):1878-80
pubmed: 16641467
Antimicrob Agents Chemother. 2009 Dec;53(12):5102-7
pubmed: 19770284
Clin Microbiol Infect. 2018 May;24 Suppl 1:e1-e38
pubmed: 29544767
Antimicrob Agents Chemother. 2013 Sep;57(9):4581-3
pubmed: 23817382
Eur Respir J. 2016 Jan;47(1):45-68
pubmed: 26699723