Emerging Bioactive Agent Delivery-Based Regenerative Therapies for Lower Genitourinary Tissues.
controlled release
regeneration medicine
reproductive system injury
urinary system injury
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
17 Aug 2022
17 Aug 2022
Historique:
received:
29
06
2022
revised:
05
08
2022
accepted:
12
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
27
8
2022
Statut:
epublish
Résumé
Injury to lower genitourinary (GU) tissues, which may result in either infertility and/or organ dysfunctions, threatens the overall health of humans. Bioactive agent-based regenerative therapy is a promising therapeutic method. However, strategies for spatiotemporal delivery of bioactive agents with optimal stability, activity, and tunable delivery for effective sustained disease management are still in need and present challenges. In this review, we present the advancements of the pivotal components in delivery systems, including biomedical innovations, system fabrication methods, and loading strategies, which may improve the performance of delivery systems for better regenerative effects. We also review the most recent developments in the application of these technologies, and the potential for delivery-based regenerative therapies to treat lower GU injuries. Recent progress suggests that the use of advanced strategies have not only made it possible to develop better and more diverse functionalities, but also more precise, and smarter bioactive agent delivery systems for regenerative therapy. Their application in lower GU injury treatment has achieved certain effects in both patients with lower genitourinary injuries and/or in model animals. The continuous evolution of biomaterials and therapeutic agents, advances in three-dimensional printing, as well as emerging techniques all show a promising future for the treatment of lower GU-related disorders and dysfunctions.
Identifiants
pubmed: 36015344
pii: pharmaceutics14081718
doi: 10.3390/pharmaceutics14081718
pmc: PMC9414065
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : The Young and Middle-aged Backbone Foundation of The Fujian Provincial Health and Family Planning Commission
ID : 2019-ZQNB-16
Organisme : Provincial Natural Science Foundation of Fujian, China
ID : 2020J05280,2021J01122110
Organisme : Health research project of Department of Finance
ID : Fujian finance refers to [2020] No. 467
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