Time-of-Day Variation in SARS-CoV-2 RNA Levels during the Second Wave of COVID-19.

COVID-19 / diagnosis COVID-19 Testing Humans Male RNA, Viral / analysis SARS-CoV-2 / genetics Specimen Handling
COVID-19 RNA SARS-CoV-2 circadian diurnal

Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
05 08 2022
Historique:
received: 16 06 2022
revised: 25 07 2022
accepted: 02 08 2022
entrez: 26 8 2022
pubmed: 27 8 2022
medline: 30 8 2022
Statut: epublish

Résumé

Circadian rhythms influence and coordinate an organism's response to its environment and to invading pathogens. We studied the diurnal variation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in nasal/throat swabs collected in late 2020 to spring 2021 in a population immunologically naïve to SARS-CoV-2 and prior to widespread vaccination. SARS-CoV-2 diagnostic PCR data from 1698 participants showed a significantly higher viral load in samples obtained in the afternoon, in males, and in hospitalised patients when linear mixed modelling was applied. This study illustrates the importance of recording sample collection times when measuring viral replication parameters in clinical and research studies.

Identifiants

DOI: 10.3390/v14081728 PMID: 36016350 PMC: PMC9413669
pubmed: 36016350
pii: v14081728
doi: 10.3390/v14081728
pmc: PMC9413669
pii:
doi:

Substances chimiques

RNA, Viral 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIA NIH HHS
ID : U54 AG062322
Pays : United States
Organisme : Wellcome Trust
ID : 110110/Z/15/Z
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : K24 HL105664
Pays : United States
Organisme : Wellcome Trust
ID : 200838/Z/16/Z
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : NICHD NIH HHS
ID : R01 HD107064
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS114001
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002541
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS099055
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA052861
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128538
Pays : United States
Organisme : Medical Research Council
ID : MR/R022011/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : P01 AG009975
Pays : United States

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Auteurs

Xiaodong Zhuang (X)

Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
ORCID: 0000-0002-6870-9003

Wei Wang (W)

Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA.

Helene Borrmann (H)

Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
ORCID: 0000-0001-7269-7925

Peter Balfe (P)

Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
ORCID: 0000-0002-6246-0876

Philippa C Matthews (PC)

The Francis Crick Institute, London NW1 1AT, UK.
Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
Department of Infection, University College London, Hospital NHS Foundation Trust, London WC1E 6BT, UK.

David W Eyre (DW)

Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.

Elizabeth B Klerman (EB)

Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA.
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.

Jane A McKeating (JA)

Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford OX3 7FZ, UK.
ORCID: 0000-0002-7229-5886

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Time-of-Day Variation in SARS-CoV-2 RNA Levels...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Dépistage de la COVID-19 › Time-of-Day Variation in SARS-CoV-2 RNA Levels...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Time-of-Day Variation in SARS-CoV-2 RNA Levels...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN viral › Time-of-Day Variation in SARS-CoV-2 RNA Levels...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Time-of-Day Variation in SARS-CoV-2 RNA Levels...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Manipulation d'échantillons › Time-of-Day Variation in SARS-CoV-2 RNA Levels...