Viral and Host Factors Regulating HIV-1 Envelope Protein Trafficking and Particle Incorporation.
AP-1 complex
AP-2 complex
Gag protein
Rab11-FIP1C
endocytosis
envelope glycoprotein
recycling
retromer
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
05 08 2022
05 08 2022
Historique:
received:
23
06
2022
revised:
25
07
2022
accepted:
02
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
The HIV-1 envelope glycoprotein (Env) is an essential structural component of the virus, serving as the receptor-binding protein and principal neutralizing determinant. Env trimers are incorporated into developing particles at the plasma membrane of infected cells. Incorporation of HIV-1 Env into particles in T cells and macrophages is regulated by the long Env cytoplasmic tail (CT) and the matrix region of Gag. The CT incorporates motifs that interact with cellular factors involved in endosomal trafficking. Env follows an unusual pathway to arrive at the site of particle assembly, first traversing the secretory pathway to the plasma membrane (PM), then undergoing endocytosis, followed by directed sorting to the site of particle assembly on the PM. Many aspects of Env trafficking remain to be defined, including the sequential events that occur following endocytosis, leading to productive recycling and particle incorporation. This review focuses on the host factors and pathways involved in Env trafficking, and discusses leading models of Env incorporation into particles.
Identifiants
pubmed: 36016351
pii: v14081729
doi: 10.3390/v14081729
pmc: PMC9415270
pii:
doi:
Substances chimiques
Carrier Proteins
0
env Gene Products, Human Immunodeficiency Virus
0
gag Gene Products, Human Immunodeficiency Virus
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI150486
Pays : United States
Organisme : NIH HHS
ID : NIH R01 AI150486
Pays : United States
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