Topography and distribution of adenosine A
A2AR
D2R
Parkinson’s disease
deep brain stimulation
neuroanatomy
neurodegeneration
receptor-receptor interactions
subthalamic nucleus
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2022
2022
Historique:
received:
16
05
2022
accepted:
20
07
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
27
8
2022
Statut:
epublish
Résumé
The human Subthalamic Nucleus (STh) is a diencephalic lens-shaped structure located ventrally to the thalamus and functionally implicated in the basal ganglia circuits. Despite recent efforts to characterize the neurochemical and functional anatomy of the STh, little to no information is available concerning the expression and distribution of receptors belonging to the dopaminergic and purinergic system in the human STh. Both systems are consistently implicated in basal ganglia physiology and pathology, especially in Parkinson's Disease, and represent important targets for the pharmacological treatment of movement disorders. Here, we investigate the topography and distribution of A
Identifiants
pubmed: 36017181
doi: 10.3389/fnins.2022.945574
pmc: PMC9396224
doi:
Types de publication
Journal Article
Langues
eng
Pagination
945574Informations de copyright
Copyright © 2022 Emmi, Antonini, Sandre, Baldo, Contran, Macchi, Guidolin, Porzionato and De Caro.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor declared a past collaboration with the authors, VM, RD, and AP.
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