Lin28a induces SOX9 and chondrocyte reprogramming via HMGA2 and blunts cartilage loss in mice.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
26 08 2022
26 08 2022
Historique:
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
31
8
2022
Statut:
ppublish
Résumé
Articular cartilage has low regenerative capacity despite permanent stress. Irreversible cartilage lesions characterize osteoarthritis (OA); this is not followed by tissue repair. Lin28a, an RNA binding protein, is detected in damaged cartilage in humans and mice. We investigated the role of LIN28a in cartilage physiology and in osteoarthritis. Lin28a-inducible conditional cartilage deletion up-regulated
Identifiants
pubmed: 36026443
doi: 10.1126/sciadv.abn3106
pmc: PMC9417174
doi:
Substances chimiques
Lin-28 protein, mouse
0
RNA-Binding Proteins
0
SOX9 Transcription Factor
0
Sox9 protein, mouse
0
Matrix Metalloproteinase 13
EC 3.4.24.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabn3106Commentaires et corrections
Type : CommentIn
Références
Nat Genet. 2009 Jul;41(7):843-8
pubmed: 19483683
Int J Mol Med. 2019 Aug;44(2):427-436
pubmed: 31173171
Cancer Immunol Res. 2019 Mar;7(3):487-497
pubmed: 30651289
Nat Genet. 1997 Jun;16(2):174-8
pubmed: 9171829
Osteoarthritis Cartilage. 2020 Oct;28(10):1373-1384
pubmed: 32659345
J Cell Sci. 2004 Feb 29;117(Pt 6):889-97
pubmed: 14762107
Science. 2012 May 11;336(6082):717-21
pubmed: 22491093
Biochem Biophys Res Commun. 2007 Jun 22;358(1):99-103
pubmed: 17482567
Cell Biol Toxicol. 2017 Aug;33(4):329-349
pubmed: 28144824
Bone Res. 2017 Jan 17;5:16044
pubmed: 28149655
Dev Biol. 2003 Jun 15;258(2):432-42
pubmed: 12798299
Arthritis Rheumatol. 2014 Nov;66(11):3028-39
pubmed: 25080367
Nature. 2011 May 5;473(7345):101-4
pubmed: 21471965
Nat Rev Rheumatol. 2015 Apr;11(4):206-12
pubmed: 25536487
Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3903-8
pubmed: 18308936
Osteoarthritis Cartilage. 2004;12 Suppl A:S53-4
pubmed: 14698643
Bone. 2018 Mar;108:145-155
pubmed: 29305998
Ann Rheum Dis. 2016 Apr;76(4):748-755
pubmed: 27789465
Nat Commun. 2017 Apr 28;8:15008
pubmed: 28452345
Cell. 2011 Sep 30;147(1):81-94
pubmed: 21962509
Oncotarget. 2018 Jan 10;9(11):9963-9974
pubmed: 29515783
Ann Rheum Dis. 2020 Dec;79(12):1625-1634
pubmed: 32963046
Osteoarthritis Cartilage. 2007 Apr;15(4):403-13
pubmed: 17098451
Nat Rev Rheumatol. 2011 Sep 27;7(11):654-63
pubmed: 21947178
Nat Med. 2020 Oct;26(10):1583-1592
pubmed: 32807933
Arthritis Rheum. 2001 Aug;44(8):1928-42
pubmed: 11508446
Biomed Pharmacother. 2019 May;113:108742
pubmed: 30851545
Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):E3291-300
pubmed: 23940373
Osteoarthritis Cartilage. 2016 Dec;24(12):2013-2021
pubmed: 27492463
Dev Cell. 2019 Feb 11;48(3):396-405.e3
pubmed: 30661985
Arthritis Rheumatol. 2015 May;67(5):1261-73
pubmed: 25603997
Proc Natl Acad Sci U S A. 2016 May 10;113(19):5453-8
pubmed: 27122313
J Neurosci. 2018 Feb 28;38(9):2246-2261
pubmed: 29378863
Front Cell Dev Biol. 2014 Mar 06;2:5
pubmed: 25364713
Development. 2015 Jul 15;142(14):2397-404
pubmed: 26199409
J Biol Chem. 2000 Apr 14;275(15):10738-44
pubmed: 10753864
Birth Defects Res C Embryo Today. 2013 Sep;99(3):192-202
pubmed: 24078496
Tissue Eng Regen Med. 2019 Jul 26;16(4):327-334
pubmed: 31413937
Nat Rev Cancer. 2007 Dec;7(12):899-910
pubmed: 18004397
World J Stem Cells. 2014 Jul 26;6(3):305-11
pubmed: 25126380
Anim Reprod Sci. 2017 Oct;185:174-180
pubmed: 28886879
Cell Res. 2007 Jan;17(1):42-9
pubmed: 17211451
J Anat. 2009 Sep;215(3):355-63
pubmed: 19563472
Sci Rep. 2018 Jul 11;8(1):10488
pubmed: 29992982
Ann Rheum Dis. 2014 Jul;73(7):1323-30
pubmed: 24553908
Science. 2007 Dec 21;318(5858):1917-20
pubmed: 18029452
Pharmacol Res Perspect. 2014 Aug;2(4):e00056
pubmed: 25505600