Colletofragarone A2 Inhibits Cancer Cell Growth

Humans Cell Line, Tumor Cell Transformation, Neoplastic Colletotrichum Cycloheximide DNA Molecular Chaperones Mutation Tumor Suppressor Protein p53 / genetics

Journal

Chemical research in toxicology
ISSN: 1520-5010
Titre abrégé: Chem Res Toxicol
Pays: United States
ID NLM: 8807448

Informations de publication

Date de publication:
19 09 2022
Historique:
pubmed: 27 8 2022
medline: 21 9 2022
entrez: 26 8 2022
Statut: ppublish

Résumé

Mutant p53 not only loses its original tumor suppressor function but also acquires new abilities regarding oncogenic progression. Therefore, the strategy of targeting mutant p53 has attracted attention for cancer therapy. We isolated colletofragarone A2 (CF) from the fungus

Identifiants

DOI: 10.1021/acs.chemrestox.2c00202 PMID: 36027604
pubmed: 36027604
doi: 10.1021/acs.chemrestox.2c00202
doi:

Substances chimiques

Cycloheximide 98600C0908
DNA 9007-49-2
Molecular Chaperones 0
Tumor Suppressor Protein p53 0
colletofragarone A2 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1598-1603

Auteurs

Yusaku Sadahiro (Y)

Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto862-0973, Japan.

Yuki Hitora (Y)

Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto862-0973, Japan.

Ichiro Kimura (I)

Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto862-0973, Japan.

Natsuko Hitora-Imamura (N)

Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto862-0973, Japan.

Risako Onodera (R)

Department of Physical Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto862-0973, Japan.

Keiichi Motoyama (K)

Department of Physical Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto862-0973, Japan.
ORCID: 0000-0002-9315-8282

Sachiko Tsukamoto (S)

Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto862-0973, Japan.
ORCID: 0000-0002-7993-381X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Colletofragarone A2 Inhibits Cancer Cell Growth
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Colletofragarone A2 Inhibits Cancer Cell Growth
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Transformation cellulaire néoplasique › Colletofragarone A2 Inhibits Cancer Cell Growth
questionsmedicales.fr › Eucaryotes › Champignons › Deuteromycota › Colletotrichum › Colletofragarone A2 Inhibits Cancer Cell Growth
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Pipéridones › Cycloheximide › Colletofragarone A2 Inhibits Cancer Cell Growth
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Colletofragarone A2 Inhibits Cancer Cell Growth
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Chaperons moléculaires › Colletofragarone A2 Inhibits Cancer Cell Growth
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Colletofragarone A2 Inhibits Cancer Cell Growth
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Protéine p53 suppresseur de tumeur › Colletofragarone A2 Inhibits Cancer Cell Growth