Racial and ethnic representation in 17-hydroxyprogesterone caproate preterm birth prevention studies: a systematic review.
17-alpha-hydroxyprogesterone caproate (17-OHPC)
17-hydroxprogesterone caproate (17-P)
ethnicity
preterm birth
race
recurrent preterm birth
Journal
Journal of perinatal medicine
ISSN: 1619-3997
Titre abrégé: J Perinat Med
Pays: Germany
ID NLM: 0361031
Informations de publication
Date de publication:
27 Sep 2022
27 Sep 2022
Historique:
received:
24
08
2021
accepted:
27
03
2022
pubmed:
27
8
2022
medline:
14
9
2022
entrez:
26
8
2022
Statut:
epublish
Résumé
The US preterm birth rate varies dramatically by race and ethnicity yet the racial and ethnic representation within studies evaluating 17-hydroxprogesterone caproate (17-P) for preterm birth prevention is unknown. The objectives of our study were to 1) examine the racial and ethnic representation of participants in 17-P preterm birth prevention studies, 2) evaluate adherence to the NIH race and ethnicity reporting guidelines and 3) compare racial and ethnic representation in research studies to national preterm birth incidence. We systematically reviewed US studies published between January 2000 and December 2019. Study participant's race and ethnicity were reported using descriptive statistics then compared to US 2017//2018 preterm birth data using Pearson's chi-square. Eighteen studies met the inclusion criteria, 17 studies reported race, 11 studies reported ethnicity, and yet none of the studies followed the NIH criteria. Compared to 2017/2018 US preterm births, the proportion of black/African American study participants was significantly higher whereas the proportions of all other race categories were lower. More detailed reporting of race and ethnicity is needed in 17-P literature. Black women appear to be well represented while other racial and ethnic groups may be understudied.
Identifiants
pubmed: 36027908
pii: jpm-2021-0425
doi: 10.1515/jpm-2021-0425
doi:
Substances chimiques
Caproates
0
17 alpha-Hydroxyprogesterone Caproate
276F2O42F5
17-alpha-Hydroxyprogesterone
68-96-2
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
970-976Informations de copyright
© 2022 Walter de Gruyter GmbH, Berlin/Boston.
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