Association of respiratory symptoms and lung function with occupation in the multinational Burden of Obstructive Lung Disease (BOLD) study.
Journal
The European respiratory journal
ISSN: 1399-3003
Titre abrégé: Eur Respir J
Pays: England
ID NLM: 8803460
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
13
03
2022
accepted:
02
08
2022
pubmed:
27
8
2022
medline:
17
1
2023
entrez:
26
8
2022
Statut:
epublish
Résumé
Chronic obstructive pulmonary disease has been associated with exposures in the workplace. We aimed to assess the association of respiratory symptoms and lung function with occupation in the Burden of Obstructive Lung Disease study. We analysed cross-sectional data from 28 823 adults (≥40 years) in 34 countries. We considered 11 occupations and grouped them by likelihood of exposure to organic dusts, inorganic dusts and fumes. The association of chronic cough, chronic phlegm, wheeze, dyspnoea, forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV Overall, working in settings with potentially high exposure to dusts or fumes was associated with respiratory symptoms but not lung function differences. The most common occupation was farming. Compared to people not working in any of the 11 considered occupations, those who were farmers for ≥20 years were more likely to have chronic cough (OR 1.52, 95% CI 1.19-1.94), wheeze (OR 1.37, 95% CI 1.16-1.63) and dyspnoea (OR 1.83, 95% CI 1.53-2.20), but not lower FVC (β=0.02 L, 95% CI -0.02-0.06 L) or lower FEV At a population level, the occupational exposures considered in this study do not appear to be major determinants of differences in lung function, although they are associated with more respiratory symptoms. Because not all work settings were included in this study, respiratory surveillance should still be encouraged among high-risk dusty and fume job workers, especially in low- and middle-income countries.
Sections du résumé
BACKGROUND
Chronic obstructive pulmonary disease has been associated with exposures in the workplace. We aimed to assess the association of respiratory symptoms and lung function with occupation in the Burden of Obstructive Lung Disease study.
METHODS
We analysed cross-sectional data from 28 823 adults (≥40 years) in 34 countries. We considered 11 occupations and grouped them by likelihood of exposure to organic dusts, inorganic dusts and fumes. The association of chronic cough, chronic phlegm, wheeze, dyspnoea, forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV
RESULTS
Overall, working in settings with potentially high exposure to dusts or fumes was associated with respiratory symptoms but not lung function differences. The most common occupation was farming. Compared to people not working in any of the 11 considered occupations, those who were farmers for ≥20 years were more likely to have chronic cough (OR 1.52, 95% CI 1.19-1.94), wheeze (OR 1.37, 95% CI 1.16-1.63) and dyspnoea (OR 1.83, 95% CI 1.53-2.20), but not lower FVC (β=0.02 L, 95% CI -0.02-0.06 L) or lower FEV
CONCLUSION
At a population level, the occupational exposures considered in this study do not appear to be major determinants of differences in lung function, although they are associated with more respiratory symptoms. Because not all work settings were included in this study, respiratory surveillance should still be encouraged among high-risk dusty and fume job workers, especially in low- and middle-income countries.
Identifiants
pubmed: 36028253
pii: 13993003.00469-2022
doi: 10.1183/13993003.00469-2022
pmc: PMC9834632
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 085790/Z/08/Z
Pays : United Kingdom
Informations de copyright
Copyright ©The authors 2023.
Déclaration de conflit d'intérêts
Conflict of interest: J. Ratanachina, A.F.S. Amaral, S. De Matteis, H. Lawin, K. Mortimer, D.O. Obaseki, I. Harrabi, M. Denguezli, E.F.M. Wouters, C. Janson, A. Gulsvik, H.H. Cherkaski, F. Mejza, P.A. Mahesh, A. Elsony, R. Ahmed, W. Tan, L.C. Loh, A. Rashid, M. Studnicka, A.A. Nafees, T. Seemungal, A. Aquart-Stewart, M. Al Ghobain, J. Zheng, S. Juvekar, S. Salvi, R. Jogi, T. Gislason, A.S. Buist, P. Cullinan and P. Burney have no conflict of interest to disclose. R. Nielsen reports grants from AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline and Novartis, and receipt of equipment/material/services from ResMed Norway; and is President of the Norwegian Respiratory Society. D. Mannino reports royalties from Up to Date; personal fees from GlaxoSmithKline, AstraZeneca and Schlesinger Law Firm; honoraria from American Association of Respiratory Care; and stock in GlaxoSmithKline; and is the Medical Director of the COPD Foundation.
Références
BMJ. 2015 Mar 16;350:h1435
pubmed: 25778910
Am J Respir Crit Care Med. 2017 Sep 12;197(5):595-610
pubmed: 28895752
Occup Environ Med. 2002 Sep;59(9):575-93; discussion 594
pubmed: 12205230
Br Med Bull. 2012;104:143-61
pubmed: 23080418
Int J Tuberc Lung Dis. 2020 Jan 1;24(1):8-21
pubmed: 32005302
Respir Med. 2011 Oct;105(10):1507-15
pubmed: 21549584
Eur Respir J. 2019 Jul 18;54(1):
pubmed: 31248951
Thorax. 2018 Nov;73(11):1008-1015
pubmed: 29574416
Br Med J. 1977 Jun 25;1(6077):1645-8
pubmed: 871704
Am J Respir Crit Care Med. 1995 Sep;152(3):1107-36
pubmed: 7663792
Am J Respir Crit Care Med. 2021 Jun 1;203(11):1353-1365
pubmed: 33171069
COPD. 2015 Aug;12(4):435-43
pubmed: 25415831
Am J Respir Crit Care Med. 2019 Jun 1;199(11):1312-1334
pubmed: 31149852
COPD. 2005 Jun;2(2):277-83
pubmed: 17136954
Int J Chron Obstruct Pulmon Dis. 2017 Feb 22;12:725-734
pubmed: 28260879
Proc R Soc Med. 1952 Sep;45(9):577-84
pubmed: 13003946
J Occup Environ Med. 2017 Mar;59(3):335-346
pubmed: 28267105
Eur Respir J. 1994 Jun;7(6):1048-55
pubmed: 7925872
Occup Environ Med. 1999 Jun;56(6):391-6
pubmed: 10474535
Ann Am Thorac Soc. 2021 Feb;18(2):238-246
pubmed: 33090904