Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
26 08 2022
26 08 2022
Historique:
received:
07
01
2022
accepted:
17
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
31
8
2022
Statut:
epublish
Résumé
Non-compressible hemorrhage is an unmet clinical challenge that accounts for high mortality in trauma. Rapid pressurized blood flows under hemorrhage impair the function and integrity of hemostatic agents and the adhesion of bioadhesive sealants. Here, we report the design and performance of bioinspired microstructured bioadhesives, formed with a macroporous tough xerogel infused with functional liquids. The xerogel can rapidly absorb interfacial fluids such as whole blood and promote blood clotting, while the infused liquids facilitate interfacial bonding, sealing, and antibacterial function. Their synergy enables the bioadhesives to form tough adhesion on ex vivo human and porcine tissues and diverse engineered surfaces without the need for compression, as well as on-demand instant removal and storage stability. We demonstrate a significantly improved hemostatic efficacy and biocompatibility in rats and pigs compared to non-structured counterparts and commercial products. This work opens new avenues for the development of bioadhesives and hemostatic sealants.
Identifiants
pubmed: 36028516
doi: 10.1038/s41467-022-32803-1
pii: 10.1038/s41467-022-32803-1
pmc: PMC9418157
doi:
Substances chimiques
Biocompatible Materials
0
Hemostatics
0
Tissue Adhesives
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
5035Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC018577
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC005788
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC014461
Pays : United States
Organisme : CIHR
ID : PJT-180232
Pays : Canada
Informations de copyright
© 2022. The Author(s).
Références
Nat Commun. 2021 Aug 5;12(1):4733
pubmed: 34354068
J R Soc Interface. 2015 Dec 6;12(113):20150827
pubmed: 26631333
Sci Rep. 2018 Dec 17;8(1):17907
pubmed: 30559364
Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):738-743
pubmed: 30602456
ACS Appl Mater Interfaces. 2021 Aug 11;13(31):37849-37861
pubmed: 34313124
Am J Physiol Gastrointest Liver Physiol. 2001 May;280(5):G922-9
pubmed: 11292601
Mater Horiz. 2020 Sep 1;7(9):2336-2347
pubmed: 33841881
Carbohydr Polym. 2020 Mar 15;232:115823
pubmed: 31952618
Nat Biomed Eng. 2021 Oct;5(10):1131-1142
pubmed: 34373600
Biomaterials. 2019 Jun;205:23-37
pubmed: 30901635
J Emerg Med. 2011 Sep;41(3):237-45
pubmed: 19345045
Biomaterials. 2022 Apr;283:121432
pubmed: 35245732
ACS Macro Lett. 2021 Feb 16;10(2):180-185
pubmed: 35570779
ACS Appl Mater Interfaces. 2020 Dec 16;12(50):55574-55583
pubmed: 33284021
Bioact Mater. 2021 Nov 10;13:260-268
pubmed: 35224307
Nature. 2019 Nov;575(7781):169-174
pubmed: 31666696
Adv Mater. 2018 Jan;30(4):
pubmed: 29164804
Adv Sci (Weinh). 2022 Jan;9(2):e2102627
pubmed: 34811970
J Mater Chem B. 2022 Jun 8;:
pubmed: 35674315
J Oral Maxillofac Surg. 1999 Jan;57(1):49-52
pubmed: 9915395
Adv Mater. 2021 Jun;33(24):e2007663
pubmed: 33956371
Matter. 2022 Feb 2;5(2):573-593
pubmed: 35695821
Sci Adv. 2021 Mar 24;7(13):
pubmed: 33762330
Sci Adv. 2015 Oct 02;1(9):e1500379
pubmed: 26601282
Sci Rep. 2020 Nov 18;10(1):20116
pubmed: 33208779
Nat Commun. 2018 Jul 17;9(1):2784
pubmed: 30018305
Nat Commun. 2019 May 14;10(1):2060
pubmed: 31089131
Nature. 2012 Sep 6;489(7414):133-6
pubmed: 22955625
Nat Biomed Eng. 2022 Jan 3;:
pubmed: 34980903
Nature. 2015 Mar 5;519(7541):70-3
pubmed: 25739629
Adv Mater. 2018 Dec;30(49):e1803217
pubmed: 30306650
Sci Adv. 2021 Jul 14;7(29):
pubmed: 34261653
Soft Matter. 2014 Feb 7;10(5):672-87
pubmed: 24834901
Sci Adv. 2019 Jul 24;5(7):eaaw3963
pubmed: 31355332
Adv Mater. 2021 Mar;33(11):e2007667
pubmed: 33522062
Science. 2017 Jul 28;357(6349):378-381
pubmed: 28751604
Adv Mater. 2018 Dec;30(50):e1802724
pubmed: 30151909
ACS Appl Bio Mater. 2019 May 20;2(5):1781-1786
pubmed: 35030668
Sci Adv. 2022 May 20;8(20):eabm9744
pubmed: 35594348
J Exp Biol. 2018 Aug 30;221(Pt 16):
pubmed: 30166319
Adv Mater. 2021 Apr;33(17):e2008553
pubmed: 33763904