A novel bio-inspired strategy to prevent amyloidogenesis and synaptic damage in Alzheimer's disease.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
15
06
2022
accepted:
11
08
2022
revised:
01
08
2022
pubmed:
27
8
2022
medline:
22
12
2022
entrez:
26
8
2022
Statut:
ppublish
Résumé
Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that affects millions of people worldwide. AD pathogenesis is intricate. It primarily involves two main molecular players-amyloid-β (Aβ) and tau-which actually have an intrinsic trend to generate molecular assemblies that are toxic to neurons. Incomplete knowledge of the molecular mechanisms inducing the onset and sustaining the progression of the disease, as well as the lack of valid models to fully recapitulate the pathogenesis of human disease, have until now hampered the development of a successful therapy for AD. The overall experience with clinical trials with a number of potential drugs-including the recent outcomes of studies with monoclonal antibodies against Aβ-seems to indicate that Aβ-targeting is not effective if it is not accompanied by an efficient challenge of Aβ neurotoxic properties. We took advantage from the discovery of a naturally-occurring variant of Aβ (Aβ
Identifiants
pubmed: 36028569
doi: 10.1038/s41380-022-01745-x
pii: 10.1038/s41380-022-01745-x
pmc: PMC9763104
doi:
Substances chimiques
Amyloid
0
Amyloid beta-Peptides
0
amyloid beta-protein (1-6)
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5227-5234Informations de copyright
© 2022. The Author(s).
Références
Neuropharmacology. 2018 Jul 1;136(Pt B):196-201
pubmed: 29180222
Nat Med. 2019 Nov;25(11):1680-1683
pubmed: 31686034
PLoS One. 2017 Oct 12;12(10):e0186347
pubmed: 29023579
Prog Neurobiol. 2012 Dec;99(3):281-92
pubmed: 22727994
J Neurosci. 2001 Mar 1;21(5):1501-9
pubmed: 11222640
Expert Opin Drug Discov. 2018 Jun;13(6):523-538
pubmed: 29607687
Crit Care Nurse. 2018 Oct;38(5):26-31
pubmed: 30275061
Sci Rep. 2017 Jul 14;7(1):5510
pubmed: 28710429
Alzheimers Dement (N Y). 2020 Jul 16;6(1):e12050
pubmed: 32695874
Sci Rep. 2015 Jan 30;5:8139
pubmed: 25633824
J Alzheimers Dis. 2018;62(3):1247-1259
pubmed: 29172000
J Biol Chem. 2014 Nov 7;289(45):30977-89
pubmed: 25253695
Nat Rev Drug Discov. 2021 Apr;20(4):309-325
pubmed: 33536635
PLoS One. 2019 Jan 25;14(1):e0210958
pubmed: 30682120
Eur J Neurol. 2018 Jan;25(1):59-70
pubmed: 28872215
BMC Neurosci. 2008 Dec 10;9 Suppl 3:S5
pubmed: 19091002
Neurol Sci. 2016 Jul;37(7):1039-47
pubmed: 26971324
Neurobiol Dis. 2014 Feb;62:521-32
pubmed: 24184799
J Biol Chem. 2017 May 19;292(20):8186-8194
pubmed: 28377502
Nature. 2012 Aug 2;488(7409):96-9
pubmed: 22801501
Int J Clin Exp Pathol. 2009;2(5):433-43
pubmed: 19294002
J Biol Chem. 2014 Nov 7;289(45):30990-1000
pubmed: 25253696
ACS Comb Sci. 2017 Feb 13;19(2):55-80
pubmed: 28045249
Science. 2009 Mar 13;323(5920):1473-7
pubmed: 19286555
Sci Rep. 2016 Feb 11;6:20949
pubmed: 26864599
Acta Neuropathol. 2011 Sep;122(3):285-92
pubmed: 21630115
Acta Neuropathol. 2017 Feb;133(2):155-175
pubmed: 28025715
FEBS J. 2017 Apr;284(7):1040-1044
pubmed: 28054745
PLoS One. 2020 Dec 28;15(12):e0237122
pubmed: 33370284
Expert Opin Investig Drugs. 2017 Jun;26(6):735-739
pubmed: 28460541
Neurobiol Dis. 2016 Apr;88:75-84
pubmed: 26792398
ACS Chem Neurosci. 2017 Sep 20;8(9):1889-1900
pubmed: 28581708
Alzheimers Dement (N Y). 2018 Apr 25;4:161-164
pubmed: 29955660
Neurobiol Dis. 2006 Dec;24(3):516-24
pubmed: 17029828
Neurobiol Aging. 2013 May;34(5):1518.e1-3
pubmed: 23102935
Brain. 2006 Nov;129(Pt 11):2992-3005
pubmed: 16844716
Mini Rev Med Chem. 2021;21(8):969-990
pubmed: 33245270
J Biol Chem. 2014 Aug 29;289(35):24143-52
pubmed: 25037228
J Vis Exp. 2013 Apr 08;(74):
pubmed: 23608783
Adv Drug Deliv Rev. 2012 May 1;64(6):531-9
pubmed: 22245080
Neuron. 1991 Apr;6(4):487-98
pubmed: 1673054
Acc Chem Res. 2021 May 4;54(9):2172-2184
pubmed: 33881820
J Biomol Struct Dyn. 2019 Oct;37(17):4590-4600
pubmed: 30526382
J Neurosci Methods. 2012 Feb 15;204(1):179-188
pubmed: 22019329
Nat Neurosci. 2005 Aug;8(8):1051-8
pubmed: 16025111
Prog Neurobiol. 2019 Mar;174:53-89
pubmed: 30599179
Curr Pharm Des. 2014;20(8):1223-43
pubmed: 23713775
J Prev Alzheimers Dis. 2021;8(4):534-551
pubmed: 34585229
Neurobiol Dis. 2004 Feb;15(1):80-92
pubmed: 14751773
Eur J Pharmacol. 2021 Oct 5;908:174310
pubmed: 34265291
Alzheimers Dement. 2021 Apr;17(4):692-695
pubmed: 33656288
J Phys Chem B. 2016 Dec 1;120(47):12111-12126
pubmed: 27933940
AIDS. 2005 Jan 28;19(2):127-35
pubmed: 15668537
Sci Rep. 2018 Feb 19;8(1):3269
pubmed: 29459625
J Neurochem. 2020 Oct;155(1):62-80
pubmed: 32491248
PLoS One. 2017 Mar 31;12(3):e0174561
pubmed: 28362827
Brain Res. 2021 May 1;1758:147342
pubmed: 33548268
Research (Wash D C). 2019 May 19;2019:5341375
pubmed: 31549066
Front Aging Neurosci. 2019 Nov 15;11:317
pubmed: 31803047
Neurobiol Dis. 2016 May;89:101-11
pubmed: 26721320
CRISPR J. 2022 Feb;5(1):109-122
pubmed: 35133877
Genes Brain Behav. 2021 Jan;20(1):e12723
pubmed: 33347690
Expert Opin Drug Discov. 2019 Jun;14(6):591-599
pubmed: 30924698
Front Pharmacol. 2014 Jun 25;5:146
pubmed: 25009496
J Control Release. 2018 Jul 10;281:139-177
pubmed: 29772289
J Cereb Blood Flow Metab. 2015 Mar;35(3):371-81
pubmed: 25492117
Stem Cell Res. 2020 Oct;48:101968
pubmed: 32911327