Fibrinogen, Fibrin, and Fibrin Degradation Products in COVID-19.
COVID-19
D-dimer
Fibrinogen
coagulation
fibrin
fibrinolysis
Journal
Current drug targets
ISSN: 1873-5592
Titre abrégé: Curr Drug Targets
Pays: United Arab Emirates
ID NLM: 100960531
Informations de publication
Date de publication:
2022
2022
Historique:
received:
29
03
2022
revised:
31
05
2022
accepted:
15
06
2022
pubmed:
28
8
2022
medline:
15
12
2022
entrez:
27
8
2022
Statut:
ppublish
Résumé
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the highly pathogenic and highly transmissible human coronavirus that is the causative agent for the worldwide COVID-19 pandemic. COVID-19 manifests predominantly as a respiratory illness with symptoms consistent with viral pneumonia, but other organ systems (e.g., kidney, heart, brain) can also become perturbed in COVID-19 patients. Accumulating data suggest that significant activation of the hemostatic system is a common pathological manifestation of SARS-CoV-2 infection. The clotting protein fibrinogen is one of the most abundant plasma proteins. Following activation of coagulation, the central coagulation protease thrombin converts fibrinogen to fibrin monomers, which selfassemble to form a matrix, the primary structural component of the blood clot. Severe COVID-19 is associated with a profound perturbation of circulating fibrinogen, intra- and extravascular fibrin deposition and persistence, and fibrin degradation. Current findings suggest high levels of fibrinogen and the fibrin degradation product D-dimer are biomarkers of poor prognosis in COVID-19. Moreover, emerging studies with in vitro and animal models indicate fibrin(ogen) as an active player in COVID-19 pathogenesis. Here, we review the current literature regarding fibrin(ogen) and COVID-19, including possible pathogenic mechanisms and treatment strategies centered on clotting and fibrin(ogen) function.
Identifiants
pubmed: 36029073
pii: CDT-EPUB-125886
doi: 10.2174/1389450123666220826162900
pmc: PMC10316333
mid: NIHMS1909300
doi:
Substances chimiques
Fibrin Fibrinogen Degradation Products
0
Fibrinogen
9001-32-5
Fibrin
9001-31-4
Types de publication
Review
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1593-1602Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL160046
Pays : United States
Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
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