Monkeypox: An international epidemic.
monkeypox virus
orthopoxvirus
Journal
Reviews in medical virology
ISSN: 1099-1654
Titre abrégé: Rev Med Virol
Pays: England
ID NLM: 9112448
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
revised:
02
08
2022
received:
13
07
2022
accepted:
12
08
2022
pubmed:
28
8
2022
medline:
15
11
2022
entrez:
27
8
2022
Statut:
ppublish
Résumé
Human monkeypox (MPX) is a viral zoonosis caused by the Monkeypox virus. For decades outbreaks exclusively occurred in the tropical rainforests of Africa, with a few imported cases and very limited human-to-human transmission outside Africa. Nevertheless, in the last years sustained outbreaks have emerged, peaking at 4600 cases in 2020 in the Democratic Republic of Congo. Since May 2022, an international epidemic originated at 2 events in Spain and Belgium led to sustained human-to-human transmission across multiple continents, mostly in males having sex with males subjects. We review here clinical presentation, epidemiology, viral evolution, vaccines, and therapeutics against human MPX.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2392Informations de copyright
© 2022 John Wiley & Sons Ltd.
Références
Durski KN, McCollum AM, Nakazawa Y, et al. Emergence of monkeypox - west and Central Africa, 1970-2017. MMWR Morb Mortal Wkly Rep. 2018;67(10):306-310. https://doi.org/10.15585/mmwr.mm6710a5
McCollum AM, Damon IK. Human monkeypox. Clin Infect Dis. 2014;58(2):260-267. https://doi.org/10.1093/cid/cit703
von Magnus P, Andersen E, Petersen K, Birch-Andersen A. A pox-like disease in cynomolgus monkeys. Acta Path Microbiol Scand. 1959;46(2):159-176. https://doi.org/10.1111/j.1699-0463.1959.tb00328.x
Ladnyj ID, Ziegler P, Kima E. A human infection caused by monkeypox virus in Basankusu Territory, Democratic Republic of the Congo. Bull World Health Organ. 1972;46:593-597.
Di Giulio DB, Eckburg PB. Human monkeypox: an emerging zoonosis. Lancet Infect Dis. 2004;4(1):15-25. https://doi.org/10.1016/s1473-3099(03)00856-9
Babkin IV, Babkina IN, Tikunova NV. An Update of orthopoxvirus molecular evolution. Viruses. 2022;14(2):388. https://doi.org/10.3390/v14020388
Hammarlund E, Dasgupta A, Pinilla C, Norori P, Früh K, Slifka MK. Monkeypox virus evades antiviral CD4+ and CD8+ T cell responses by suppressing cognate T cell activation. Proc Natl Acad Sci U. S. A. 2008;105(38):14567-14572. https://doi.org/10.1073/pnas.0800589105
Damon IK. Status of human monkeypox: clinical disease, epidemiology and research. Vaccine. 2011;29(Suppl 4):D54-D59. https://doi.org/10.1016/j.vaccine.2011.04.014
Brown K, Leggat PA. Human monkeypox: current state of knowledge and implications for the future. Trop Med Infect Dis. 2016;1:8. https://doi.org/10.3390/tropicalmed1010008
Yinka-Ogunleye A, Aruna O, Ogoina D, et al. Reemergence of human monkeypox in Nigeria. Emerg Infect Dis. 2018;24(6):1149-1151. https://doi.org/10.3201/eid2406.180017
Chen N, Li G, Liszewski MK, et al. Virulence differences between monkeypox virus isolates from West Africa and the Congo basin. Virology. 2005;340(1):46-63. https://doi.org/10.1016/j.virol.2005.05.030
Likos AM, Sammons SA, Olson VA, et al. A tale of two clades: monkeypox viruses. J Gen Virol. 2005;86(10):2661-2672. https://doi.org/10.1099/vir.0.81215-0
Saijo M, Ami Y, Suzaki Y, et al. Virulence and pathophysiology of the Congo Basin and West African strains of monkeypox virus in non-human primates. J Gen Virol. 2009;90(9):2266-2271. https://doi.org/10.1099/vir.0.010207-0
Petersen E, Kantele A, Koopmans M, et al. Human monkeypox: epidemiologic and clinical characteristics, diagnosis, and prevention. Infect Dis Clin North Am. 2019;33(4):1027-1043. https://doi.org/10.1016/j.idc.2019.03.001
Khodakevich L, Jezek Z, Kinzanzka K. Isolation of monkeypox virus from wild squirrel infected in nature. Lancet. 1986;1(8472):98-99. https://doi.org/10.1016/s0140-6736(86)90748-8
Radonić A, Metzger S, Dabrowski PW, et al. Fatal monkeypox in wild-living sooty mangabey, Côte d'Ivoire, 2012. Emerg Infect Dis. 2014;20(6):1009-1011. https://doi.org/10.3201/eid2006.13-1329
Monkeypox Viruses Circulate in Distantly-Related Small Mammal Species in the Democratic Republic of the Congo. August 20, 2022. Accessed August 20, 2022. https://www.researchsquare.com/article/rs-414280/v1(2021)%20doi:10.21203/rs.3.rs-414280/v1
Patrono LV, Pléh K, Samuni L, et al. Monkeypox virus emergence in wild chimpanzees reveals distinct clinical outcomes and viral diversity. Nat Microbiol. 2020;5(7):955-965. https://doi.org/10.1038/s41564-020-0706-0
From the Centers for Disease Control and Prevention. Multistate outbreak of monkeypox-- Illinois, Indiana, and Wisconsin. JAMA. 2003;290:30-31. https://doi.org/10.1001/jama.290.1.30
Nolen LD, Osadebe L, Katomba J, et al. Introduction of monkeypox into a community and household: risk factors and zoonotic reservoirs in the democratic republic of the Congo. Am J Trop Med Hyg. 2015;93(2):410-415. https://doi.org/10.4269/ajtmh.15-0168
Schultz DA, Sagartz JE, Huso DL, Buller RM. Experimental infection of an African dormouse (Graphiurus kelleni) with monkeypox virus. Virology. 2009;383(1):86-92. https://doi.org/10.1016/j.virol.2008.09.025
Breman JG, Kalisa R, Steniowski MV, Zanotto E, Gromyko AI, Arita I. Human monkeypox, 1970-79. Bull World Health Organ. 1980;58:165-182.
Human monkeypox -- Kasai Oriental. Democratic republic of Congo. MMWR Morb Mortal Wkly Rep. 1997;46:1168-1171.
Yinka-Ogunleye A, Aruna O, Dalhat M, et al. Outbreak of human monkeypox in Nigeria in 2017-18: a clinical and epidemiological report. Lancet Infect Dis. 2019;19(8):872-879. https://doi.org/10.1016/s1473-3099(19)30294-4
Bunge EM, Hoet B, Chen L, et al. The changing epidemiology of human monkeypox-A potential threat? A systematic review. PLoS Negl Trop Dis. 2022;16(2):e0010141. https://doi.org/10.1371/journal.pntd.0010141
Kalthan E, Tenguere J, Ndjapou SG, et al. Investigation of an outbreak of monkeypox in an area occupied by armed groups, Central African Republic. Med Mal Infect. 2018;48(4):263-268. https://doi.org/10.1016/j.medmal.2018.02.010
Reynolds MG, Wauquier N, Li Y, et al. Human monkeypox in Sierra Leone after 44-year absence of reported cases. Emerg Infect Dis. 2019;25(5):1023-1025. https://doi.org/10.3201/eid2505.180832
Kabuga AI, El Zowalaty ME. A review of the monkeypox virus and a recent outbreak of skin rash disease in Nigeria. J Med Virol. 2019;91(4):533-540. https://doi.org/10.1002/jmv.25348
Ogoina D, Izibewule JH, Ogunleye A, et al. The 2017 human monkeypox outbreak in Nigeria-Report of outbreak experience and response in the Niger Delta University Teaching Hospital, Bayelsa State, Nigeria. PLoS One. 2019;14(4):e0214229. https://doi.org/10.1371/journal.pone.0214229
Reynolds MG, Yorita KL, Kuehnert MJ, et al. Clinical manifestations of human monkeypox influenced by route of infection. J Infect Dis. 2006;194(6):773-780. https://doi.org/10.1086/505880
Vaughan A, Aarons E, Astbury J, et al. Two cases of monkeypox imported to the United Kingdom, September 2018. Euro Surveill. 2018;23(38). https://doi.org/10.2807/1560-7917.Es.2018.23.38.1800509
Erez N, Achdout H, Milrot E, et al. Diagnosis of imported monkeypox, Israel, 2018. Emerg Infect Dis. 2019;25(5):980-983. https://doi.org/10.3201/eid2505.190076
Angelo KM, Petersen BW, Hamer DH, Schwartz E, Brunette G. Monkeypox transmission among international travellers-serious monkey business? J Travel Med. 2019;26(5). https://doi.org/10.1093/jtm/taz002
Vivancos R, Anderson C, Blomquist P, et al. Community transmission of monkeypox in the United Kingdom, April to May 2022. Euro Surveill. 2022;27(22). https://doi.org/10.2807/1560-7917.Es.2022.27.22.2200422
Isidro J, Borges V, Pinto M, et al. First Draft Genome Sequence of Monkeypox Virus Associated with the Suspected Multi-Country Outbreak, May 2022 (Confirmed Case in Portugal). Accessed online at 21 May 2022. https://virological.org/t/first-draft-genome-sequence-of-monkeypox-virus-associated-with-the-suspected-multi-country-outbreak-may-2022-confirmed-case-in-portugal/799%20on
Perez Duque M, Ribeiro S, Martins JV, et al. Ongoing monkeypox virus outbreak, Portugal, 29 April to 23 May 2022. Euro Surveill. 2022;27(22). https://doi.org/10.2807/1560-7917.Es.2022.27.22.2200424
Spanish Draft Genome Sequence of Monkeypox Virus Related to Multi-Country Outbreak. (2022). https://virological.org/t/spanish-draft-genome-sequence-of-monkeypox-virus-related-to-multi-country-outbreak-may-2022/825
Second Draft Genome from Spain of the Monkeypox Virus 2022 Outbreak. August 20, 2022. Accessed August 20, 2022. https://virological.org/t/second-draft-genome-from-spain-of-the-monkeypox-virus-2022-outbreak/846
de Nicolas-Ruanes B, Vivancos MJ, Azcarraga-Llobet C, et al. Monkeypox virus case with maculopapular exanthem and proctitis during the Spanish outbreak in 2022. J Eur Acad Dermatol Venereol. 2022;36(8). https://doi.org/10.1111/jdv.18300
First Monkeypox Genome Sequence from Italy. August 20, 2022. Accessed August 20, 2022. https://virological.org/t/first-monkeypox-genome-sequence-from-italy/824
First Available Monkeypox Genome Sequence from the First Case in Italy Related to Multi-Country Outbreak in May 2022. https://virological.org/t/first-available-monkeypox-genome-sequence-from-the-first-case-in-italy-related-to-multi-country-outbreak-in-may-2022/833
Ferraro F, Caraglia A, Rapiti A, et al. Letter to the editor: multiple introductions of MPX in Italy from different geographic areas. Euro Surveill. 2022;27(23). https://doi.org/10.2807/1560-7917.Es.2022.27.23.2200456
Antinori A, Mazzotta V, Vita S, et al. Epidemiological, clinical and virological characteristics of four cases of monkeypox support transmission through sexual contact, Italy. Euro Surveill. 2022(22):27. https://doi.org/10.2807/1560-7917.Es.2022.27.22.2200421
First German Genome Sequence of Monkeypox Virus Associated to Multi-Country Outbreak in May 2022. https://virological.org/t/first-german-genome-sequence-of-monkeypox-virus-associated-to-multi-country-outbreak-in-may-2022/812
Travel-associated Monkeypox Virus Genomes from Two German Patients and of a Derived Virus Isolate All Closely Related to a US Sequence, 2022. https://virological.org/t/travel-associated-monkeypox-virus-genomes-from-two-german-patients-and-of-a-derived-virus-isolate-all-closely-related-to-a-us-sequence-2022/844
Clinical and Virological Features of First Human Monkeypox Cases in Germany, 2022, PREPRINT (Version 1). https://doi.org/10.21203/rs.3.rs-1725831/v1
Two Draft Canadian Monkeypox Virus (MPXV) Genomes, 2022. https://virological.org/t/two-draft-canadian-monkeypox-virus-mpxv-genomes-june-2022/870
Sukhdeo SS, Aldhaheri K, Lam PW, Walmsley S. A case of human monkeypox in Canada. CMAJ (Can Med Assoc J). 2022;194(29):E1031-E1035. https://doi.org/10.1503/cmaj.220886
Selhorst P, Rezende A, de Block T, et al. Belgian Case of Monkeypox Virus Linked to Outbreak in Portugal. on. Accessed online at 21 May 2022. https://virological.org/t/belgian-case-of-monkeypox-virus-linked-to-outbreak-in-portugal/801
Vanmechelen B, Wawina-Bokalanga T, Maes P. A Monkeypox Virus Genome from a Second Belgian Case; 2022.
Hammerschlag Y, MacLeod G, Papadakis G, et al. Monkeypox infection presenting as genital rash, Australia. Euro Surveill. 2022;27(22). https://doi.org/10.2807/1560-7917.Es.2022.27.22.2200411
Croville G, Walch MG JL, Mansuy J, Pasquier C, Izopet J. First French Draft Genome Sequence of Monkeypox Virus, May 2022; 2022.
Illumina Whole-Genome Sequence of Monkeypox Virus in a Patient Travelling from the Canary Islands to France. August 20, 2022. Accessed August 20, 2022. https://virological.org/t/illumina-whole-genome-sequence-of-monkeypox-virus-in-a-patient-travelling-from-the-canary-islands-to-france/829
MinIon-produced Illumina-Confirmed Genomes of the Two First Isolated Cases from France. August 20, 2022. Accessed August 20, 2022. https://virological.org/t/minion-produced-illumina-confirmed-genomes-of-the-two-first-isolated-cases-from-france/868
First 2022 Monkeypox Outbreak Genome Sequences from Slovenia. August 20, 2022. Accessed August 20, 2022. https://virological.org/t/first-2022-monkeypox-outbreak-genome-sequences-from-slovenia/841
Oprea C, Ianache I, Piscu S, et al. First report of monkeypox in a patient living with HIV from Romania. Trav Med Infect Dis. 2022;49:102395. https://doi.org/10.1016/j.tmaid.2022.102395
First Monkeypox Genome Sequence from the Netherlands. August 20, 2022. Accessed August 20, 2022. https://virological.org/t/first-monkeypox-genome-sequence-from-the-netherlands/821
First Israeli Whole-Genome Sequence of Monkeypox Virus Associated with the May 2022 Multi Country Outbreak. August 20, 2022. Accessed August 20, 2022. https://virological.org/t/first-israeli-whole-genome-sequence-of-monkeypox-virus-associated-with-the-may-2022-multi-country-outbreak/843
Bížová B, Veselý D, Trojánek M, Rob F. Coinfection of syphilis and monkeypox in HIV positive man in Prague, Czech Republic. Trav Med Infect Dis. 2022;49:102368. https://doi.org/10.1016/j.tmaid.2022.102368
First Monkeypox Virus Genome Sequence from Brazil. August 20, 2022. Accessed August 20, 2022. https://virological.org/t/first-monkeypox-virus-genome-sequence-from-brazil/850
Monkeypox Virus Genome Sequence from an Imported Case in Colombia. August 20, 2022. Accessed August 20, 2022. https://virological.org/t/monkeypox-virus-genome-sequence-from-an-imported-case-in-colombia/880
First Monkeypox Virus Sequence from Northern Mexico. August 20, 2022. Accessed August 20, 2022. https://virological.org/t/first-monkeypox-virus-sequence-from-northern-mexico/882
Liu Z, Wu H, Egland KA, et al. Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variants. Hum Vaccin Immunother. 2021;18(2):1-10. https://doi.org/10.1080/21645515.2021.1940652
Minhaj FS, Ogale YP, Whitehill F, et al. Monkeypox outbreak - nine states, May 2022. MMWR Morb Mortal Wkly Rep. 2022;71(23):764-769. https://doi.org/10.15585/mmwr.mm7123e1
Mahase E. Monkeypox: healthcare workers will be offered smallpox vaccine as UK buys 20 000 doses. Bmj. 2022;377:o1379. https://doi.org/10.1136/bmj.o1379
Minhaj FS, Rao AK, McCollum A. Imported monkeypox from international traveler, Maryland, USA. Emerg Infect Dis. 2022(8):28. https://doi.org/10.3201/eid2808.220726
Costello V, Sowash M, Gaur A, et al. Imported monkeypox from international traveler, Maryland, USA, 2021 (response). Emerg Infect Dis. 2022;28(8):1739. https://doi.org/10.3201/eid2808.220830
Mauldin MR, McCollum AM, Nakazawa YJ, et al. Exportation of monkeypox virus from the African continent. J Infect Dis. 2022;225(8):1367-1376. https://doi.org/10.1093/infdis/jiaa559
Firth C, Kitchen A, Shapiro B, Suchard MA, Holmes EC, Rambaut A. Using time-structured data to estimate evolutionary rates of double-stranded DNA viruses. Mol Biol Evol. 2010;27(9):2038-2051. https://doi.org/10.1093/molbev/msq088
Pecori R, Di Giorgio S, Paulo Lorenzo J, Nina Papavasiliou F. Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination. Nat Rev Genet. 2022;23(8):505-518. https://doi.org/10.1038/s41576-022-00459-8
Initial Observations about Putative APOBEC3 Deaminase Editing Driving Short-Term Evolution of MPXV since 2017. https://virological.org/t/initial-observations-about-putative-apobec3-deaminase-editing-driving-short-term-evolution-of-mpxv-since-2017/830
Yu Q, König R, Pillai S, et al. Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome. Nat Struct Mol Biol. 2004;11(5):435-442. https://doi.org/10.1038/nsmb758
Kremer M, Suezer Y, Martinez-Fernandez Y, Münk C, Sutter G, Schnierle BS. Vaccinia virus replication is not affected by APOBEC3 family members. Virol J. 2006;3(1):86. https://doi.org/10.1186/1743-422x-3-86
Update to Observations about Putative APOBEC3 Deaminase Editing in the Light of New Genomes from USA. August 20, 2022. Accessed August 20, 2022. https://virological.org/t/update-to-observations-about-putative-apobec3-deaminase-editing-in-the-light-of-new-genomes-from-usa/847
Multi-country Outbreak of Monkeypox Virus: Genetic Divergence and First Signs of Microevolution. August 20, 2022. Accessed August 20, 2022. https://virological.org/t/multi-country-outbreak-of-monkeypox-virus-genetic-divergence-and-first-signs-of-microevolution/806
Kugelman JR, Johnston SC, Mulembakani PM, et al. Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo. Emerg Infect Dis. 2014;20(2):232-239. https://doi.org/10.3201/eid2002.130118
Shchelkunov SN, Totmenin AV, Safronov PF, et al. Analysis of the monkeypox virus genome. Virology. 2002;297(2):172-194. https://doi.org/10.1006/viro.2002.1446
Gubser C, Hué S, Kellam P, Smith GL. Poxvirus genomes: a phylogenetic analysis. J Gen Virol. 2004;85(1):105-117. https://doi.org/10.1099/vir.0.19565-0
Monkeypox Virus Genome Sequences from Multiple Lesions Indicates Co-infection of a UK Returning Traveller. August 20, Accessed August 20, 2022. https://virological.org/t/monkeypox-virus-genome-sequences-from-multiple-lesions-indicates-co-infection-of-a-uk-returning-traveller/873
Kozlov M. Monkeypox vaccination begins - can the global outbreaks be contained? Nature. 2022;606(7914):444-445. https://doi.org/10.1038/d41586-022-01587-1
Kupferschmidt K. WHO holds off on global alarm for monkeypox. Science. 2022;377(6601):17. https://doi.org/10.1126/science.add6994
Tarín-Vicente EJ, Alemany A, Agud-Dios M, et al. Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study. Lancet. 2022. https://doi.org/10.1016/S0140-6736(22)01436-2
Happi C, Adetifa I, Mbala P, et al. Urgent Need for a Non-discriminatory and Non-stigmatizing Nomenclature for Monkeypox Virus; 2022.
Seang S, Burrel S, Todesco E, et al. Evidence of human-to-dog transmission of monkeypox virus. Lancet. 2022. https://doi.org/10.1016/S0140-6736(22)01487-8
Nörz D, Pfefferle S, Brehm TT, et al. Evidence of surface contamination in hospital rooms occupied by patients infected with monkeypox, Germany, June 2022. Euro Surveill. 2022;27(26). https://doi.org/10.2807/1560-7917.Es.2022.27.26.2200477
Vaughan A, Aarons E, Astbury J, et al. Human-to-Human transmission of monkeypox virus, United Kingdom. Emerg Infect Dis. 2020;26(4):782-785. https://doi.org/10.3201/eid2604.191164
Doshi RH, Guagliardo SAJ, Doty JB, et al. Epidemiologic and ecologic investigations of monkeypox, Likouala department, republic of the Congo. Emerg Infect Dis. 2019;25(2):281-289. https://doi.org/10.3201/eid2502.181222
Heskin J, Belfield A, Milne C, et al. Transmission of monkeypox virus through sexual contact - a novel route of infection. J Infect. 2022;85(3):334-363. https://doi.org/10.1016/j.jinf.2022.05.028
Why the Monkeypox Outbreak Is Mostly Affecting Men Who Have Sex with Men. August 20, 2022. Accessed August 20, 2022. https://www.science.org/content/article/monkeypox-outbreak-mostly-affecting-men-sex-men
Mbala PK, Huggins JW, Riu-Rovira T, et al. Maternal and fetal outcomes among pregnant women with human monkeypox infection in the democratic republic of Congo. J Infect Dis. 2017;216(7):824-828. https://doi.org/10.1093/infdis/jix260
Learned LA, Reynolds MG, Wassa DW, et al. Extended interhuman transmission of monkeypox in a hospital community in the Republic of the Congo, 2003. Am J Trop Med Hyg. 2005;73(2):428-434. https://doi.org/10.4269/ajtmh.2005.73.428
Thornhill JP, Barkati S, Walmsley S, et al. Monkeypox Virus Infection in Humans across 16 Countries - April-June 2022; 2022. https://doi.org/10.1056/NEJMoa2207323
Lapa D, Carletti F, Mazzotta V, et al. Monkeypox virus isolation from a semen sample collected in the early phase of infection in a patient with prolonged seminal viral shedding. Lancet Infect Dis. 2022. https://doi.org/10.1016/S1473-3099(22)00513-8
Bamberger TC, Pankow S, Martinez-Bartolome S, Diedrich J, Park R, Yates JR. The Host Interactome of Spike Expands the Tropism of SARS-CoV-2. J bioRxiv. 2021. https://doi.org/10.1101/2021.02.16.431318
Nörz D, Tang HT, Emmerich P, et al. Rapid Adaptation of Established High-Throughput Molecular Testing Infrastructure for Detection of Monkeypoxvirus. J bioRxiv. 2022. 22276011. https://doi.org/10.1101/2022.06.05.22276011
Karem KL, Reynolds M, Hughes C, et al. Monkeypox-induced immunity and failure of childhood smallpox vaccination to provide complete protection. Clin Vaccine Immunol. 2007;14(10):1318-1327. https://doi.org/10.1128/cvi.00148-07
Lewis MW, Graham MB, Hammarlund E, Hanifin J, Slifka MK. Monkeypox without exanthem. N Engl J Med. 2007;356(20):2112-2114. https://doi.org/10.1056/NEJMc062788
Mande G, Akonda I, De Weggheleire A, et al. Enhanced Surveillance of Monkeypox in Bas-Uélé, Democratic Republic of Congo: The Limitations of Symptom-Based Case Definitions. J bioRxiv. 2022. https://doi.org/10.1101/2022.06.03.22275815
Jezek Z, Grab B, Szczeniowski MV, Paluku KM, Mutombo M. Human monkeypox: secondary attack rates. Bull World Health Organ. 1988;66:465-470.
Lederman ER, Reynolds MG, Karem K, et al. Prevalence of antibodies against orthopoxviruses among residents of Likouala region, Republic of Congo: evidence for monkeypox virus exposure. Am J Trop Med Hyg. 2007;77(6):1150-1156. https://doi.org/10.4269/ajtmh.2007.77.1150
Davido B, D’anglejan E, Jourdan J, Robinault A, Davido G. Monkeypox 2022 outbreak: cases with exclusive genital lesions. J Trav Med. 2022. https://doi.org/10.1093/jtm/taac077
Patrocinio-Jesus R, Peruzzu F. Monkeypox Genit Lesions. 2022. https://doi.org/10.1056/NEJMicm2206893
Girometti N, Byrne R, Bracchi M, et al. Demographic and clinical characteristics of confirmed human monkeypox virus cases in individuals attending a sexual health centre in London, UK: an observational analysis. Lancet Infect Dis. 2022. https://doi.org/10.1016/S1473-3099(22)00411-X
Silico Identification of Non-cross-reactive Epitopes for Monkeypox Cell Surface-Binding Protein, 2022, PREPRINT (Version 1). https://doi.org/10.21203/rs.3.rs-1693979/v1
Pittman PR, Martin JW, Kingebeni PM, et al. Clinical Characterization of Human Monkeypox Infections in the Democratic Republic of the Congo. J bioRxiv. 2022. https://doi.org/10.1101/2022.05.26.22273379
Rao AK, Petersen BW, Whitehill F, et al. Use of JYNNEOS (smallpox and monkeypox vaccine, live, nonreplicating) for preexposure vaccination of persons at risk for occupational exposure to orthopoxviruses: recommendations of the advisory committee on immunization practices - United States, 2022. MMWR Morb Mortal Wkly Rep. 2022;71(22):734-742. https://doi.org/10.15585/mmwr.mm7122e1
Jezek Z, Marennikova SS, Mutumbo M, Nakano JH, Paluku KM, Szczeniowski M. Human monkeypox: a study of 2, 510 contacts of 214 patients. J Infect Dis. 1986;154(4):551-555. https://doi.org/10.1093/infdis/154.4.551
Hammarlund E, Lewis MW, Carter SV, et al. Multiple diagnostic techniques identify previously vaccinated individuals with protective immunity against monkeypox. Nat Med. 2005;11(9):1005-1011. https://doi.org/10.1038/nm1273
Update: multistate outbreak of monkeypox--Illinois, Indiana, Kansas, Missouri, Ohio, and Wisconsin, 2003. MMWR Morb Mortal Wkly Rep. 2003;52:642-646.
Russo AT, Berhanu A, Bigger CB, et al. Co-administration of tecovirimat and ACAM2000™ in non-human primates: effect of tecovirimat treatment on ACAM2000 immunogenicity and efficacy versus lethal monkeypox virus challenge. Vaccine. 2020;38(3):644-654. https://doi.org/10.1016/j.vaccine.2019.10.049
Wittek R. Vaccinia immune globulin: current policies, preparedness, and product safety and efficacy. Int J Infect Dis. 2006;10(3):193-201. https://doi.org/10.1016/j.ijid.2005.12.001
Parker S, D'Angelo J, Buller RM, et al. A human recombinant analogue to plasma-derived vaccinia immunoglobulin prophylactically and therapeutically protects against lethal orthopoxvirus challenge. Antivir Res. 2021;195:105179. https://doi.org/10.1016/j.antiviral.2021.105179
Li Y, Zhao H, Wilkins K, Hughes C, Damon IK. Real-time PCR assays for the specific detection of monkeypox virus West African and Congo Basin strain DNA. J Virol Methods. 2010;169(1):223-227. https://doi.org/10.1016/j.jviromet.2010.07.012
Smee DF, Bailey KW, Wong MH, Wandersee MK, Sidwell RW. Topical cidofovir is more effective than is parenteral therapy for treatment of progressive vaccinia in immunocompromised mice. J Infect Dis. 2004;190(6):1132-1139. https://doi.org/10.1086/422696
Bray M. Pathogenesis and potential antiviral therapy of complications of smallpox vaccination. Antivir Res. 2003;58(2):101-114. https://doi.org/10.1016/s0166-3542(03)00008-1
De Clercq E. Cidofovir in the treatment of poxvirus infections. Antivir Res. 2002;55:1-13. https://doi.org/10.1016/s0166-3542(02)00008-6
Quenelle DC, Collins DJ, Kern ER. Efficacy of multiple- or single-dose cidofovir against vaccinia and cowpox virus infections in mice. Antimicrob Agents Chemother. 2003;47(10):3275-3280. https://doi.org/10.1128/aac.47.10.3275-3280.2003
Yang G, Pevear DC, Davies MH, et al. An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus Challenge. J Virol. 2005;79(20):13139-13149. https://doi.org/10.1128/JVI.79.20.13139-13149.2005
Cono J, Casey CG, Bell DM. Smallpox vaccination and adverse reactions. Guidance for clinicians. MMWR Recomm Rep. 2003;52:1-28.
Andrei G, Snoeck R. Cidofovir activity against poxvirus infections. Viruses. 2010;2(12):2803-2830. https://doi.org/10.3390/v2122803
Farlow J, Ichou MA, Huggins J, Ibrahim S. Comparative whole genome sequence analysis of wild-type and cidofovir-resistant monkeypoxvirus. Virol J. 2010;7(1):110. https://doi.org/10.1186/1743-422x-7-110
Siqueira JD, Goes LR, Alves BM, et al. Distinguishing SARS-CoV-2 bonafide re-infection from pre-existing minor variant reactivation. Infect Genet Evol. 2021;90:104772. https://doi.org/10.1016/j.meegid.2021.104772
Lederman ER, Davidson W, Groff HL, et al. Progressive vaccinia: case description and laboratory-guided therapy with vaccinia immune globulin, ST-246, and CMX001. J Infect Dis. 2012;206(9):1372-1385. https://doi.org/10.1093/infdis/jis510
Vora S, Damon I, Fulginiti V, et al. Severe eczema vaccinatum in a household contact of a smallpox vaccinee. Clin Infect Dis. 2008;46(10):1555-1561. https://doi.org/10.1086/587668
Augusto Ribeiro Do Valle L, Raposo De Melo P, Florêncio De Salles Gomes L, Morato Proença L. Methisazone in prevention of VARIOLA minor among contacts. Lancet. 1965;286(7420):976-978. https://doi.org/10.1016/S0140-6736(65)92840-0
Bauer DJ, St Vincent L, Kempe CH, Young PA, Downie AW. Prophylaxis of smallpox with methisazone. Am J Epidemiol. 1969;90(2):130-145. https://doi.org/10.1093/oxfordjournals.aje.a121057
Nalca A, Zumbrun EE. ACAM2000: the new smallpox vaccine for United States Strategic National Stockpile. Drug Des Dev Ther. 2010;4:71-79. https://doi.org/10.2147/dddt.s3687
Kenner J, Cameron F, Empig C, Jobes DV, Gurwith M. LC16m8: an attenuated smallpox vaccine. Vaccine. 2006;24(47-48):7009-7022. https://doi.org/10.1016/j.vaccine.2006.03.087
Meseda CA, Mayer AE, Kumar A, et al. Comparative evaluation of the immune responses and protection engendered by LC16m8 and Dryvax smallpox vaccines in a mouse model. Clin Vaccine Immunol. 2009;16(9):1261-1271. https://doi.org/10.1128/cvi.00040-09
Morikawa S, Sakiyama T, Hasegawa H, et al. An attenuated LC16m8 smallpox vaccine: analysis of full-genome sequence and induction of immune protection. J Virol. 2005;79(18):11873-11891. https://doi.org/10.1128/jvi.79.18.11873-11891.2005
Empig C, Kenner JR, Perret-Gentil M, et al. Highly attenuated smallpox vaccine protects rabbits and mice against pathogenic orthopoxvirus challenge. Vaccine. 2006;24(17):3686-3694. https://doi.org/10.1016/j.vaccine.2005.03.029
Overton ET, Lawrence SJ, Wagner E, et al. Immunogenicity and safety of three consecutive production lots of the non replicating smallpox vaccine MVA: a randomised, double blind, placebo controlled phase III trial. PLoS One. 2018;13(4):e0195897. https://doi.org/10.1371/journal.pone.0195897
Zitzmann-Roth EM, von Sonnenburg F, de la Motte S, et al. Cardiac safety of Modified Vaccinia Ankara for vaccination against smallpox in a young, healthy study population. PLoS One. 2015;10(4):e0122653. https://doi.org/10.1371/journal.pone.0122653
Greenberg RN, Hay CM, Stapleton JT, et al. A randomized, double-blind, placebo-controlled phase II trial investigating the safety and immunogenicity of modified vaccinia Ankara smallpox vaccine (MVA-BN®) in 56-80-year-old subjects. PLoS One. 2016;11(6):e0157335. https://doi.org/10.1371/journal.pone.0157335
Greenberg RN, Hurley MY, Dinh DV, et al. A multicenter, open-label, controlled phase II study to evaluate safety and immunogenicity of MVA smallpox vaccine (IMVAMUNE) in 18-40 Year old subjects with diagnosed atopic dermatitis. PLoS One. 2015;10:e0138348. https://doi.org/10.1371/journal.pone.0138348
Pittman PR, Hahn M, Lee HS, et al. Phase 3 efficacy trial of modified vaccinia Ankara as a vaccine against smallpox. N Engl J Med. 2019;381(20):1897-1908. https://doi.org/10.1056/NEJMoa1817307
Kraemer MUG, Tegally H, Pigott DM, et al. Tracking the 2022 monkeypox outbreak with epidemiological data in real-time. Lancet Infect Dis. 2022;22(7):941-942. https://doi.org/10.1016/S1473-3099(22)00359-0