Exploring the pivotal role of endothelin in rheumatoid arthritis.
Chronic inflammation
Endothelins
Interleukins
Pro-inflammatory cytokines
Rheumatoid arthritis
Journal
Inflammopharmacology
ISSN: 1568-5608
Titre abrégé: Inflammopharmacology
Pays: Switzerland
ID NLM: 9112626
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
11
03
2022
accepted:
01
07
2022
pubmed:
28
8
2022
medline:
28
9
2022
entrez:
27
8
2022
Statut:
ppublish
Résumé
A chronic inflammatory disorder, rheumatoid arthritis (RA) is an autoimmune and systemic disease characterized by progressive and prolonged destruction of joints. This results in increased mortality, physical disability and destruction. Cardiovascular disorders are one of the primary causes of mortality in patients with RA. It is multifactorial in nature and includes genetic, environmental and demographic factors which contribute to the severity of disease. Endothelin-1 (ET-1) is a peptide which acts as a potent vasoconstrictor and is generated through vascular smooth muscle and endothelial cells. Endothelins may be responsible for RA, as under certain circumstances they produce reactive oxygen species which further promote the production of pro-inflammatory cytokines. This enhances the production of superoxide anion, which activates pro-inflammatory cytokines, resulting in RA. The aim of this review is to elucidate the role of endothelin in the progression of RA. This review also summarizes the natural and synthetic anti-inflammatory drugs which have provided remarkable insights in targeting endothelin.
Identifiants
pubmed: 36029362
doi: 10.1007/s10787-022-01051-6
pii: 10.1007/s10787-022-01051-6
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Cytokines
0
Endothelin-1
0
Endothelins
0
Reactive Oxygen Species
0
Vasoconstrictor Agents
0
Superoxides
11062-77-4
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1555-1567Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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