Nitro compounds against trypanosomatidae parasites: Heroes or villains?
Leishmania
Medicinal chemistry
Nitrofuran
Nitroindazole
Nitroreductase
Trypanosoma
Journal
Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377
Informations de publication
Date de publication:
01 11 2022
01 11 2022
Historique:
received:
18
06
2022
revised:
28
07
2022
accepted:
08
08
2022
pubmed:
28
8
2022
medline:
4
10
2022
entrez:
27
8
2022
Statut:
ppublish
Résumé
Chagas disease and Human African trypanosomiasis (HAT) are caused by Trypanosoma cruzi, T. brucei rhodesiense or T. b. gambiense parasites, respectively; while Leishmania is caused by parasites from the Leishmania genus. In recent years, many efforts have been addressed to develop inhibitors against these parasites, especially nitro-containing derivatives, which can interfere with essential enzymes from the protozoa. In this review, all anti-trypanosomatidae nitrocompounds reported so far are shown herein, highlighting their activities and SAR analyses, providing all the benefits and problems associated with this ambiguous chemical group. Finally, this review paper will be useful for many research teams around the world, which are searching for novel trypanocidal and leishmanicidal agents.
Identifiants
pubmed: 36030001
pii: S0960-894X(22)00406-1
doi: 10.1016/j.bmcl.2022.128930
pii:
doi:
Substances chimiques
Nitro Compounds
0
Trypanocidal Agents
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
128930Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.