Mechanisms of thrombosis in pancreatic ductal adenocarcinoma.
Cancer-associated thrombosis
Extracellular vesicles
Hypercoagulability
Tissue factor
Venous thrombosis
Journal
Best practice & research. Clinical haematology
ISSN: 1532-1924
Titre abrégé: Best Pract Res Clin Haematol
Pays: Netherlands
ID NLM: 101120659
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
16
05
2022
accepted:
19
05
2022
entrez:
27
8
2022
pubmed:
28
8
2022
medline:
31
8
2022
Statut:
ppublish
Résumé
Patients with pancreatic cancer have a very high risk of both venous and arterial thrombosis compared with other cancers, caused by a tumour-driven hypercoagulable state. Better understanding of pancreatic cancer-associated prothrombotic and proinflammatory mechanisms opens the door to controlling prothrombotic states, ideally, without affecting the overall haemostasis. This narrative review brings together currently available evidence on epidemiology and pathogenesis of thrombotic complications in pancreatic adenocarcinoma. We describe risk factors for thrombosis and established and novel mechanisms of hypercoagulability. Among novel pathways of hypercoagulability, the release of neutrophils extracellular traps (NETs) by activated neutrophils and the crucial role of extracellular vesicles (EV) in participating in platelet and coagulation activation were described. We also reported recent evidence on EV role in thrombin generation amplification through the activation of the intrinsic pathway, discussing potential molecules implicated in this process.
Identifiants
pubmed: 36030065
pii: S1521-6926(22)00001-9
doi: 10.1016/j.beha.2022.101346
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101346Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.