Patch grafting of organoids of stem/progenitors into solid organs can correct genetic-based disease states.

Animals Biliary Tract Liver Mice Organoids / metabolism Pancreas / metabolism Stem Cells / metabolism Swine
Biliary tree Cell therapies Diabetes Liver Organoids Pancreas Patch grafting Stem/progenitors Tyrosinemia

Journal

Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316

Informations de publication

Date de publication:
09 2022
Historique:
received: 02 05 2022
revised: 18 06 2022
accepted: 22 06 2022
pubmed: 28 8 2022
medline: 9 9 2022
entrez: 27 8 2022
Statut: ppublish

Résumé

Patch grafting, a novel strategy for transplantation of stem/progenitor organoids into porcine livers, has been found successful also for organoid transplantation into other normal or diseased solid organs in pigs and mice. Each organoid contained ∼100 cells comprised of biliary tree stem cells (BTSCs), co-hepato/pancreatic stem/progenitors, and partnered with early lineage stage mesenchymal cells (ELSMCs), angioblasts and precursors to endothelia and stellate cells. Patch grafting enabled transplantation into livers or pancreases of ≥10

Identifiants

DOI: 10.1016/j.biomaterials.2022.121647 PMID: 36030102 PMC: PMC10495116
pubmed: 36030102
pii: S0142-9612(22)00287-3
doi: 10.1016/j.biomaterials.2022.121647
pmc: PMC10495116
mid: NIHMS1924470
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

121647

Subventions

Organisme : NCI NIH HHS
ID : P30 CA016086
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK034987
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB002025
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL051587
Pays : United States

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no conflict of interest.

Références

Cell Transplant. 2012;21(1):1-10
pubmed: 21457616
Curr Transplant Rep. 2017;4(3):184-192
pubmed: 28932649
Prog Mol Biol Transl Sci. 2017;147:1-73
pubmed: 28413025
Sci Rep. 2014 Jun 17;4:5290
pubmed: 24936832
Exp Cell Res. 2004 Jul 15;297(2):329-47
pubmed: 15212938
Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12132-7
pubmed: 11050242
Diabetes. 2002 Jan;51(1):66-72
pubmed: 11756324
PLoS One. 2017 Jan 12;12(1):e0169242
pubmed: 28081156
Lancet Oncol. 2020 Mar;21(3):e168-e178
pubmed: 32135120
Prog Polym Sci. 2007;32(8-9):991-1007
pubmed: 19543442
Biomaterials. 2015 Apr;47:1-12
pubmed: 25682155
Biomaterials. 2021 Oct;277:121067
pubmed: 34517276
Stem Cell Res. 2014 Jul;13(1):144-53
pubmed: 24879068
J Biol Chem. 2000 Sep 1;275(35):26967-75
pubmed: 10871609
Burns. 2018 May;44(3):549-559
pubmed: 29183637
Nat Protoc. 2017 Aug;12(8):1521-1541
pubmed: 28683063
Semin Liver Dis. 2001 Aug;21(3):373-84
pubmed: 11586466
Xenotransplantation. 2007 Jul;14(4):288-97
pubmed: 17669170
Int J Biochem Cell Biol. 2016 Dec;81(Pt A):166-173
pubmed: 27640754
Biomaterials. 2011 Oct;32(30):7389-402
pubmed: 21788068
ACS Appl Mater Interfaces. 2016 Aug 31;8(34):21861-8
pubmed: 26849288
Nat Rev Gastroenterol Hepatol. 2012 Feb 28;9(4):231-40
pubmed: 22371217
Genesis. 2004 Dec;40(4):241-6
pubmed: 15593332
Cell Death Dis. 2014 Aug 14;5:e1370
pubmed: 25118930
Hepatology. 2011 Dec;54(6):2159-72
pubmed: 21809358
Mol Ther. 2005 Jul;12(1):42-8
pubmed: 15963919
Front Biosci. 1998 Jul 01;3:d604-15
pubmed: 9634543
J Hepatol. 2023 Jan;78(1):165-179
pubmed: 36089156
Matrix Biol. 2015 May-Jul;44-46:224-31
pubmed: 25599938
World J Gastrointest Surg. 2009 Nov 30;1(1):16-20
pubmed: 21160790
Diabetes. 2010 Sep;59(9):2265-70
pubmed: 20570944
Transplantation. 2010 Oct 27;90(8):807-10
pubmed: 20706179
Cell Stem Cell. 2015 Jul 2;17(1):11-22
pubmed: 26140604
Oncogene. 2004 Jul 29;23(34):5815-22
pubmed: 15184870
Science. 2020 Oct 16;370(6514):
pubmed: 33060332
J Tissue Eng Regen Med. 2018 Apr;12(4):1062-1073
pubmed: 29106037

Auteurs

Wencheng Zhang (W)

Department of Cell Biology and Physiology, UNC School of Medicine, Chapel Hill, NC 27599, USA; Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200123, China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai, 200120, China; Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai, 200335, China. Electronic address: wencheng.v.zhang@outlook.com.

Eliane Wauthier (E)

Department of Cell Biology and Physiology, UNC School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: elwauthier@gmail.com.

Giacomo Lanzoni (G)

Diabetes Research Institute, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136, USA. Electronic address: giacomo.lanzoni@gmail.com.

Homayoun Hani (H)

Department of Cell Biology and Physiology, UNC School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: h.hani@gmail.com.

Xianwen Yi (X)

Department of Surgery, UNC School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: xianwen_yi@med.unc.edu.

Diletta Overi (D)

Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Roma RM, Italy. Electronic address: diletta.overi@uniroma1.it.

Lei Shi (L)

Department of Cell Biology and Physiology, UNC School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: 302shilei@gmail.com.

Sean Simpson (S)

Department of Molecular Biomedical Sciences, North Carolina State College of Veterinary Medicine, Raleigh, NC 27606, USA; The Comparative Medicine Institute, North Carolina State College of Veterinary Medicine, Raleigh, NC 27606, USA; Department of Comparative Veterinary Anatomy, North Carolina State College of Veterinary Medicine, Raleigh, NC 27606, USA. Electronic address: seangsimpson.ss@gmail.com.

Amanda Allen (A)

Department of Cell Biology and Physiology, UNC School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: volare266@gmail.com.

Carolyn Suitt (C)

Center on Gastrointestinal Disease Biology (CGIBD) Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: carolyn_suitt@med.unc.edu.

Jennifer Ashley Ezzell (JA)

Department of Cell Biology and Physiology, UNC School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: j.ezzell@email.unc.edu.

Domenico Alvaro (D)

Center on Gastrointestinal Disease Biology (CGIBD) Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: domenico.alvaro@uniroma.it.

Vincenzo Cardinale (V)

Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Roma RM, Italy. Electronic address: v.cardinale80@gmail.com.

Eugenio Gaudio (E)

Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Roma RM, Italy. Electronic address: eugenio.gaudio@uniroma.it.

Guido Carpino (G)

Translational and Precision Medicine, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Roma RM, Italy. Electronic address: guido.carpino@uniroma.it.

Glenn Prestwich (G)

Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, 00135, Italy. Electronic address: Glenn.Prestwich@pharm.utah.edu.

Juan Dominguez-Bendala (J)

Diabetes Research Institute, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136, USA. Electronic address: jDominguez2@med.miami.edu.

David Gerber (D)

Department of Surgery, UNC School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: David_Gerber@med.unc.edu.

Kyle Mathews (K)

Department of Clinical Sciences, North Carolina State College of Veterinary Medicine, Raleigh, NC 27606, USA. Electronic address: kmathews@ncsu.edu.

Jorge Piedrahita (J)

Department of Molecular Biomedical Sciences, North Carolina State College of Veterinary Medicine, Raleigh, NC 27606, USA; The Comparative Medicine Institute, North Carolina State College of Veterinary Medicine, Raleigh, NC 27606, USA; Department of Comparative Veterinary Anatomy, North Carolina State College of Veterinary Medicine, Raleigh, NC 27606, USA. Electronic address: japiedra@ncsu.edu.

Christopher Adin (C)

Department of Clinical Sciences, North Carolina State College of Veterinary Medicine, Raleigh, NC 27606, USA. Electronic address: adinc@ufl.edu.

Praveen Sethupathy (P)

Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: pr46@cornell.edu.

Zhiying He (Z)

Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200123, China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai, 200120, China; Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai, 200335, China. Electronic address: zyhe@tongji.edu.cn.

Lola M Reid (LM)

Department of Cell Biology and Physiology, UNC School of Medicine, Chapel Hill, NC 27599, USA; Cornell University College of Veterinary Medicine, T7 006D Veterinary Research Tower, Box 17, Ithaca, NY 14853, USA. Electronic address: stemcell@med.unc.edu.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Patch grafting of organoids of...
questionsmedicales.fr › Système digestif › Voies biliaires › Patch grafting of organoids of...
questionsmedicales.fr › Système digestif › Foie › Patch grafting of organoids of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Patch grafting of organoids of...
questionsmedicales.fr › Tissus › Organoïdes › Patch grafting of organoids of...
questionsmedicales.fr › Système digestif › Pancréas › Patch grafting of organoids of...
questionsmedicales.fr › Cellules › Cellules souches › Patch grafting of organoids of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Patch grafting of organoids of...