Epigenetic regulation in intervertebral disc degeneration.

Epigenesis, Genetic Humans Intervertebral Disc Intervertebral Disc Degeneration / genetics
DNA methylation RNA methylation epigenetic regulation histone modification intervertebral disc degeneration nucleus pulposus cell

Journal

Trends in molecular medicine
ISSN: 1471-499X
Titre abrégé: Trends Mol Med
Pays: England
ID NLM: 100966035

Informations de publication

Date de publication:
10 2022
Historique:
received: 09 06 2022
revised: 29 07 2022
accepted: 29 07 2022
pubmed: 28 8 2022
medline: 28 9 2022
entrez: 27 8 2022
Statut: ppublish

Résumé

Intervertebral disc (IVD) degeneration is the leading cause of low back pain, which has a striking impact on numerous patients. Therefore, comprehensively illuminating the regulatory mechanisms of IVD degeneration is of great significance. Here, we discuss the latest advances in understanding the main epigenetic mechanisms regulating IVD degeneration.

Identifiants

DOI: 10.1016/j.molmed.2022.07.007 PMID: 36030154
pubmed: 36030154
pii: S1471-4914(22)00187-3
doi: 10.1016/j.molmed.2022.07.007
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

803-805

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests No interests to declare.

Auteurs

Gaocai Li (G)

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, China.

Weifeng Zhang (W)

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, China.

Huaizhen Liang (H)

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, China.

Cao Yang (C)

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, China. Electronic address: caoyangunion@hust.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Epigenetic regulation in intervertebral disc...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Epigenetic regulation in intervertebral disc...
questionsmedicales.fr › Tissus › Tissu conjonctif › Cartilage › Fibrocartilage › Disque intervertébral › Epigenetic regulation in intervertebral disc...
questionsmedicales.fr › Maladies ostéomusculaires › Maladies osseuses › Maladies du rachis › Dégénérescence de disque intervertébral › Epigenetic regulation in intervertebral disc...