The Dual Pandemics of COVID-19 and Obesity: Bidirectional Impact.

Bidirectional impact COVID-19 Obesity SARS-CoV-2 Syndemic

Journal

Diabetes therapy : research, treatment and education of diabetes and related disorders
ISSN: 1869-6953
Titre abrégé: Diabetes Ther
Pays: United States
ID NLM: 101539025

Informations de publication

Date de publication:
Oct 2022
Historique:
received: 15 06 2022
accepted: 02 08 2022
pubmed: 28 8 2022
medline: 28 8 2022
entrez: 27 8 2022
Statut: ppublish

Résumé

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the COVID-19 pandemic, has been shown to disrupt many organ systems in the human body. Though several medical disorders have been affected by this infection, a few illnesses in addition may also play a role in determining the outcome of COVID-19. Obesity is one such disease which is not only affected by the occurrence of COVID-19 but can also result in a worse clinical outcome of COVID-19 infection. This manuscript summarizes the most recent evidence supporting the bidirectional impact of COVID-19 and obesity. It highlights how the presence of obesity can be detrimental to the outcome of COVID-19 in a given patient because of the mechanical limitations in lung compliance and also by the activation of several thrombo-inflammatory pathways. The sociodemographic changes brought about by the pandemic in turn have facilitated the already increasing prevalence of obesity. This manuscript highlights the importance of recognizing these pathways which may further help in policy changes that facilitate appropriate measures to prevent the further worsening of these two pandemics.

Identifiants

DOI: 10.1007/s13300-022-01311-2 PMID: 36030317 PMC: PMC9419639
pubmed: 36030317
doi: 10.1007/s13300-022-01311-2
pii: 10.1007/s13300-022-01311-2
pmc: PMC9419639
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

1723-1736

Informations de copyright

© 2022. The Author(s).

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Auteurs

Nitin Kapoor (N)

Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, India.
Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.

Sanjay Kalra (S)

Department of Endocrinology, Bharti Hospital, B.R.I.D.E., Karnal, 132001, India. brideknl@gmail.com.

Wael Al Mahmeed (W)

Heart and Vascular Institute, Cleveland Clinic, Abu Dhabi, United Arab Emirates.

Khalid Al-Rasadi (K)

Medical Research Center, Sultan Qaboos University, Muscat, Oman.

Kamila Al-Alawi (K)

Department of Training and Studies, Royal Hospital, Ministry of Health, Muscat, Oman.

Maciej Banach (M)

Department of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL), Lodz, Poland.
Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland.
Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland.

Yajnavalka Banerjee (Y)

Department of Biochemistry, Mohammed Bin Rashid University, Dubai, United Arab Emirates.

Antonio Ceriello (A)

IRCCS MultiMedica, Milan, Italy.

Mustafa Cesur (M)

Clinic of Endocrinology, Ankara Güven Hospital, Ankara, Turkey.

Francesco Cosentino (F)

Unit of Cardiology, Karolinska Institute and Karolinska University Hospital, University of Stockholm, Stockholm, Sweden.

Alberto Firenze (A)

Unit of Research and International Cooperation, University Hospital of Palermo, Palermo, Italy.

Massimo Galia (M)

Department of Biomedicine, Neurosciences and Advanced Diagnostics (Bind), University of Palermo, Palermo, Italy.

Su-Yen Goh (SY)

Department of Endocrinology, Singapore General Hospital, Singapore, Singapore.

Andrej Janez (A)

Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia.

Peter Kempler (P)

Department of Medicine and Oncology, Semmelweis University, Budapest, Hungary.

Nader Lessan (N)

The Research Institute, Imperial College London Diabetes Centre, Abu Dhabi, United Arab Emirates.

Paulo Lotufo (P)

Center for Clinical and Epidemiological Research, University Hospital, University of São Paulo, São Paulo, Brazil.

Nikolaos Papanas (N)

Diabetes Center, Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece.

Ali A Rizvi (AA)

Department of Medicine, University of Central Florida College of Medicine, Orlando, FL, USA.

Amirhossein Sahebkar (A)

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Raul D Santos (RD)

Heart Institute (InCor), University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil.
Hospital Israelita Albert Einstein, Sao Paulo, Brazil.

Anca Pantea Stoian (AP)

Faculty of Medicine, Diabetes, Nutrition and Metabolic Diseases, Carol Davila University, Bucharest, Romania.

Peter P Toth (PP)

Cicarrone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Vijay Viswanathan (V)

Diabetes Research Centre, Chennai, India.

Manfredi Rizzo (M)

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (Promise), School of Medicine, University of Palermo, Palermo, Italy.

Classifications MeSH