Intergrader agreement of foveal cone topography measured using adaptive optics scanning light ophthalmoscopy.
Journal
Biomedical optics express
ISSN: 2156-7085
Titre abrégé: Biomed Opt Express
Pays: United States
ID NLM: 101540630
Informations de publication
Date de publication:
01 Aug 2022
01 Aug 2022
Historique:
received:
27
04
2022
revised:
11
07
2022
accepted:
12
07
2022
entrez:
29
8
2022
pubmed:
30
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
The foveal cone mosaic can be directly visualized using adaptive optics scanning light ophthalmoscopy (AOSLO). Previous studies in individuals with normal vision report wide variability in the topography of the foveal cone mosaic, especially the value of peak cone density (PCD). While these studies often involve a human grader, there have been no studies examining intergrader reproducibility of foveal cone mosaic metrics. Here we re-analyzed published AOSLO foveal cone images from 44 individuals to assess the relationship between the cone density centroid (CDC) location and the location of PCD. Across 5 graders with variable experience, we found a measurement error of 11.7% in PCD estimates and higher intergrader reproducibility of CDC location compared to PCD location (p < 0.0001). These estimates of measurement error can be used in future studies of the foveal cone mosaic, and our results support use of the CDC location as a more reproducible anchor for cross-modality analyses.
Identifiants
pubmed: 36032569
doi: 10.1364/BOE.460821
pii: 460821
pmc: PMC9408252
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4445-4454Subventions
Organisme : NEI NIH HHS
ID : R01 EY033580
Pays : United States
Organisme : NEI NIH HHS
ID : R44 EY031278
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY017607
Pays : United States
Organisme : NEI NIH HHS
ID : F31 EY033204
Pays : United States
Organisme : NCRR NIH HHS
ID : C06 RR016511
Pays : United States
Informations de copyright
© 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.
Déclaration de conflit d'intérêts
RFC: Translational Imaging Innovations (I); JC: Translational Imaging Innovations (I) Optovue, (F), AGTC (F), MeiraGTx (F). Remaining authors declare no conflicts of interest.
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