Host cell stress response as a predictor of COVID-19 infectivity and disease progression.

COVID-19 SARS–CoV–2 cell stress responses drug target heat shock proteins stress proteins

Journal

Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173

Informations de publication

Date de publication:
2022
Historique:
received: 06 05 2022
accepted: 15 07 2022
entrez: 29 8 2022
pubmed: 30 8 2022
medline: 30 8 2022
Statut: epublish

Résumé

The coronavirus disease (COVID-19) caused by a coronavirus identified in December 2019 has caused a global pandemic. COVID-19 was declared a pandemic in March 2020 and has led to more than 6.3 million deaths. The pandemic has disrupted world travel, economies, and lifestyles worldwide. Although vaccination has been an effective tool to reduce the severity and spread of the disease there is a need for more concerted approaches to fighting the disease. COVID-19 is characterised as a severe acute respiratory syndrome . The severity of the disease is associated with a battery of comorbidities such as cardiovascular diseases, cancer, chronic lung disease, and renal disease. These underlying diseases are associated with general cellular stress. Thus, COVID-19 exacerbates outcomes of the underlying conditions. Consequently, coronavirus infection and the various underlying conditions converge to present a combined strain on the cellular response. While the host response to the stress is primarily intended to be of benefit, the outcomes are occasionally unpredictable because the cellular stress response is a function of complex factors. This review discusses the role of the host stress response as a convergent point for COVID-19 and several non-communicable diseases. We further discuss the merits of targeting the host stress response to manage the clinical outcomes of COVID-19.

Identifiants

pubmed: 36032680
doi: 10.3389/fmolb.2022.938099
pii: 938099
pmc: PMC9411049
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

938099

Informations de copyright

Copyright © 2022 Caillet, Stofberg, Muleya, Shonhai and Zininga.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Celine Caillet (C)

Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa.

Melissa Louise Stofberg (ML)

Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa.

Victor Muleya (V)

Department of Biochemistry, Midlands State University, Gweru, Zimbabwe.

Addmore Shonhai (A)

Department of Biochemistry and Microbiology, University of Venda, Thohoyandou, South Africa.

Tawanda Zininga (T)

Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa.

Classifications MeSH