SHH and Notch regulate SOX9+ progenitors to govern arcuate POMC neurogenesis.
EMT
Notch
POMC
SHH
SOX9
hypothalamus
neurogenesis
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2022
2022
Historique:
received:
15
01
2022
accepted:
20
07
2022
entrez:
29
8
2022
pubmed:
30
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
Pro-opiomelanocortin (POMC)-expressing neurons in the hypothalamic arcuate nucleus (ARC) play key roles in feeding and energy homoeostasis, hence their development is of great research interest. As the process of neurogenesis is accompanied by changes in adhesion, polarity, and migration that resemble aspects of epithelial-to-mesenchymal transitions (EMTs), we have characterised the expression and regulation within the prospective ARC of transcription factors with context-dependent abilities to regulate aspects of EMT. Informed by pseudotime meta-analysis of recent scRNA-seq data, we use immunohistochemistry and multiplex
Identifiants
pubmed: 36033614
doi: 10.3389/fnins.2022.855288
pmc: PMC9404380
doi:
Types de publication
Journal Article
Langues
eng
Pagination
855288Informations de copyright
Copyright © 2022 Place, Manning, Kim, Kinjo, Nakamura and Ohyama.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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