S6 kinase 1 at the central node of cell size and ageing.
ageing
growth
mTOR
nutrition
senescence
signal transduction
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2022
2022
Historique:
received:
20
05
2022
accepted:
07
07
2022
entrez:
29
8
2022
pubmed:
30
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
Genetic evidence in living organisms from yeast to plants and animals, including humans, unquestionably identifies the Target Of Rapamycin kinase (TOR or mTOR for mammalian/mechanistic) signal transduction pathway as a master regulator of growth through the control of cell size and cell number. Among the mTOR targets, the activation of p70 S6 kinase 1 (S6K1) is exquisitely sensitive to nutrient availability and rapamycin inhibition. Of note,
Identifiants
pubmed: 36036012
doi: 10.3389/fcell.2022.949196
pii: 949196
pmc: PMC9417411
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
949196Informations de copyright
Copyright © 2022 Fumagalli and Pende.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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