The First Dipeptide Mimetic of Neurotrofin-3: Design and Pharmacological Properties.
GTS-301 dipeptide
Trk receptors
antidepressant activity
mimetic
neuroprotective activity
neurotrophin-3
Journal
Doklady. Biochemistry and biophysics
ISSN: 1608-3091
Titre abrégé: Dokl Biochem Biophys
Pays: United States
ID NLM: 101126895
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
02
04
2022
accepted:
04
05
2022
revised:
04
05
2022
entrez:
29
8
2022
pubmed:
30
8
2022
medline:
1
9
2022
Statut:
ppublish
Résumé
The dimeric dipeptide mimetic hexamethylenediamide bis-(N-monosuccinyl-L-asparaginyl-L-asparagine) (GTS-301) was created on the basis of the structure of the exposed region of the neurotrophin-3 4th loop. The new compound, as well as the full-length neurotrophin, activated the TrkC and TrkB receptors. GTS-301 showed neuroprotective activity in experiments on HT-22 mouse hippocampal cells under conditions of oxidative stress and glutamate toxicity at concentrations of 10
Identifiants
pubmed: 36038682
doi: 10.1134/S1607672922040032
pii: 10.1134/S1607672922040032
doi:
Substances chimiques
Antidepressive Agents
0
Dipeptides
0
Nerve Growth Factors
0
Receptor, trkB
EC 2.7.10.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
160-165Informations de copyright
© 2022. Pleiades Publishing, Ltd.
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