Extubation in neurocritical care patients: the ENIO international prospective study.
Brain injury
Extubation
Intra-cranial haemorrhage
Tracheostomy
Traumatic brain injury
Journal
Intensive care medicine
ISSN: 1432-1238
Titre abrégé: Intensive Care Med
Pays: United States
ID NLM: 7704851
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
02
05
2022
accepted:
12
07
2022
pubmed:
30
8
2022
medline:
27
10
2022
entrez:
29
8
2022
Statut:
ppublish
Résumé
Neurocritical care patients receive prolonged invasive mechanical ventilation (IMV), but there is poor specific information in this high-risk population about the liberation strategies of invasive mechanical ventilation. ENIO (NCT03400904) is an international, prospective observational study, in 73 intensive care units (ICUs) in 18 countries from 2018 to 2020. Neurocritical care patients with a Glasgow Coma Score (GCS) ≤ 12, receiving IMV ≥ 24 h, undergoing extubation attempt or tracheostomy were included. The primary endpoint was extubation failure by day 5. An extubation success prediction score was created, with 2/3 of patients randomly allocated to the training cohort and 1/3 to the validation cohort. Secondary endpoints were the duration of IMV and in-ICU mortality. 1512 patients were included. Among the 1193 (78.9%) patients who underwent an extubation attempt, 231 (19.4%) failures were recorded. The score for successful extubation prediction retained 20 variables as independent predictors. The area under the curve (AUC) in the training cohort was 0.79 95% confidence interval (CI In neurocritical care patients, extubation failure is high and is associated with unfavourable outcomes. A score could predict extubation success in multiple settings. However, it will be mandatory to validate our findings in another prospective independent cohort.
Identifiants
pubmed: 36038713
doi: 10.1007/s00134-022-06825-8
pii: 10.1007/s00134-022-06825-8
doi:
Types de publication
Observational Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1539-1550Investigateurs
Paër-Sélim Abback
(PS)
Anaïs Codorniu
(A)
Giuseppe Citerio
(G)
Vittoria Ludovica Sala
(VL)
Marinella Astuto
(M)
Eleonora Tringali
(E)
Daniela Alampi
(D)
Monica Rocco
(M)
Jessica Giuseppina Maugeri
(JG)
Agrippino Bellissima
(A)
Matteo Filippini
(M)
Nicoletta Lazzeri
(N)
Andrea Cortegiani
(A)
Mariachiara Ippolito
(M)
Chiara Robba
(C)
Denise Battaglini
(D)
Patrick Biston
(P)
Mohamed Fathi Al-Gharyani
(MF)
Russell Chabanne
(R)
Léo Astier
(L)
Benjamin Soyer
(B)
Samuel Gaugain
(S)
Alice Zimmerli
(A)
Urs Pietsch
(U)
Miodrag Filipovic
(M)
Giovanna Brandi
(G)
Giulio Bicciato
(G)
Ainhoa Serrano
(A)
Berta Monleon
(B)
Peter van Vliet
(P)
Benjamin Marcel Gerretsen
(BM)
Iris Xochitl Ortiz-Macias
(IX)
Jun Oto
(J)
Noriya Enomoto
(N)
Tomomichi Matsuda
(T)
Nobutaka Masui
(N)
Pierre Garçon
(P)
Jonathan Zarka
(J)
Wytze J Vermeijden
(WJ)
Alexander Daniel Cornet
(AD)
Sergio Reyes Inurrigarro
(SR)
Rafael Cirino Lara Domínguez
(RCL)
Maria Mercedes Bellini
(MM)
Maria Milagros Gomez Haedo
(MMG)
Laura Lamot
(L)
Jose Orquera
(J)
Matthieu Biais
(M)
Delphine Georges
(D)
Arvind Baronia
(A)
Roberto Carlos Miranda-Ackerman
(RC)
Francisco José Barbosa-Camacho
(FJ)
John Porter
(J)
Miguel Lopez-Morales
(M)
Thomas Geeraerts
(T)
Baptiste Compagnon
(B)
David Pérez-Torres
(D)
Estefanía Prol-Silva
(E)
Hana Basheer Yahya
(HB)
Ala Khaled
(A)
Mohamed Ghula
(M)
Cracchiolo Neville Andrea
(CN)
Palma Maria Daniela
(PM)
Cristian Deana
(C)
Luigi Vetrugno
(L)
Manuel J Rivera Chavez
(MJR)
Rocio Mendoza Trujillo
(RM)
Vincent Legros
(V)
Benjamin Brochet
(B)
Olivier Huet
(O)
Marie Geslain
(M)
Mathieu van der Jagt
(M)
Job van Steenkiste
(J)
Hazem Ahmed
(H)
Alexander Edward Coombs
(AE)
Jessie Welbourne
(J)
Ana Alicia Velarde Pineda
(AAV)
Víctor Hugo Nubert Castillo
(VHN)
Mohammed A Azab
(MA)
Ahmed Y Azzam
(AY)
David Michael Paul van Meenen
(DMP)
Gilberto Adrian Gasca
(GA)
Alfredo Arellano
(A)
Forttino Galicia-Espinosa
(F)
José Carlos García-Ramos
(JC)
Ghanshyam Yadav
(G)
Amarendra Kumar Jha
(AK)
Vincent Robert-Edan
(V)
Pierre-Andre Rodie-Talbere
(PA)
Gaurav Jain
(G)
Sagarika Panda
(S)
Sonika Agarwal
(S)
Yashbir Deewan
(Y)
Gilberto Adrian Gasca
(GA)
Alfredo Arellano
(A)
Syed Tariq Reza
(ST)
Md Mozaffer Hossain
(MM)
Christos Papadas
(C)
Vasiliki Chantziara
(V)
Chrysanthi Sklavou
(C)
Yannick Hourmant
(Y)
Nicolas Grillot
(N)
Job van Steenkiste
(J)
Mathieu van der Jagt
(M)
Romain Pirracchio
(R)
Abdelraouf Akkari
(A)
Mohamed Abdelaty
(M)
Ahmed Hashim
(A)
Yoann Launey
(Y)
Elodie Masseret
(E)
Sigismond Lasocki
(S)
Soizic Gergaud
(S)
Nicolas Mouclier
(N)
Sulekha Saxena
(S)
Avinash Agrawal
(A)
Shakti Bedanta Mishra
(SB)
Samir Samal
(S)
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2022. Springer-Verlag GmbH Germany, part of Springer Nature.
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