Posttranslational control of lipogenesis in the tumor microenvironment.
Cancer
Lipid metabolism reprogramming
Posttranslational modification
Tumor microenvironment
Journal
Journal of hematology & oncology
ISSN: 1756-8722
Titre abrégé: J Hematol Oncol
Pays: England
ID NLM: 101468937
Informations de publication
Date de publication:
29 08 2022
29 08 2022
Historique:
received:
13
04
2022
accepted:
11
08
2022
entrez:
29
8
2022
pubmed:
30
8
2022
medline:
1
9
2022
Statut:
epublish
Résumé
Metabolic reprogramming of cancer cells within the tumor microenvironment typically occurs in response to increased nutritional, translation and proliferative demands. Altered lipid metabolism is a marker of tumor progression that is frequently observed in aggressive tumors with poor prognosis. Underlying these abnormal metabolic behaviors are posttranslational modifications (PTMs) of lipid metabolism-related enzymes and other factors that can impact their activity and/or subcellular localization. This review focuses on the roles of these PTMs and specifically on how they permit the re-wiring of cancer lipid metabolism, particularly within the context of the tumor microenvironment.
Identifiants
pubmed: 36038892
doi: 10.1186/s13045-022-01340-1
pii: 10.1186/s13045-022-01340-1
pmc: PMC9422141
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
120Informations de copyright
© 2022. The Author(s).
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