Malignant phyllodes tumor of the breast with metastases to the lungs: A case report and literature review.
Case report
Lung metastasis
Malignant phyllodes tumor
Recurrence
Journal
Radiology case reports
ISSN: 1930-0433
Titre abrégé: Radiol Case Rep
Pays: Netherlands
ID NLM: 101467888
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
19
06
2022
revised:
03
07
2022
accepted:
06
07
2022
entrez:
30
8
2022
pubmed:
31
8
2022
medline:
31
8
2022
Statut:
epublish
Résumé
Phyllodes tumors (PTs) are rare fibroepithelial neoplasms of the breasts. Approximately 10%-15% of PTs are malignant, and 9%-27% of patients with malignant PTs, develop metastatic disease. The lungs are the most common target organ for distant metastasis of PT. We report a case of 44-year-old female with a malignant PT. It had recurred locally 3 times, and 3 relapses occurred 13 months after the first diagnosis, presenting multiple metastases to the lungs by CT scan. The patient underwent radiation therapy, and palliative chemotherapy with doxorubicin was initiated. Two courses of doxorubicin therapy were administered, but the patient expired 16 months after PT diagnosis. We present a rare case of malignant PT with local recurrences, lung metastases, and poor patient outcome. Although malignant breast PTs have an unfavorable prognosis, adjuvant radiotherapy combined with margin-negative resection may be associated with decreased local recurrence and distant metastasis rates. Future research should include randomized clinical trials or well-designed prospective matched studies to clarify the effectiveness of treatments of PTs.
Identifiants
pubmed: 36039084
doi: 10.1016/j.radcr.2022.07.037
pii: S1930-0433(22)00582-9
pmc: PMC9418210
doi:
Types de publication
Case Reports
Langues
eng
Pagination
4006-4012Informations de copyright
© 2022 The Authors.
Références
Arch Pathol Lab Med. 2016 Jul;140(7):665-71
pubmed: 27362571
Proc (Bayl Univ Med Cent). 2019 Jan 15;32(1):116-118
pubmed: 30956603
Case Rep Oncol. 2016 Dec 14;9(3):861-868
pubmed: 28203179
Ann Surg Oncol. 2019 May;26(5):1263-1275
pubmed: 30617873
Indian J Surg Oncol. 2015 Dec;6(4):363-9
pubmed: 27065662
Medicine (Baltimore). 2019 May;98(22):e15762
pubmed: 31145295
Histopathology. 2016 Jan;68(1):5-21
pubmed: 26768026
BMC Res Notes. 2017 Jan 19;10(1):55
pubmed: 28103951
J Radiol Case Rep. 2013 Feb 01;7(2):24-37
pubmed: 23705037
Histopathology. 1987 Jul;11(7):761-2
pubmed: 3040567
Virchows Arch. 2018 Apr;472(4):615-621
pubmed: 29127495
Ann Surg Oncol. 2009 Aug;16(8):2288-94
pubmed: 19424757
Surg Case Rep. 2020 Dec 7;6(1):308
pubmed: 33284362
J Surg Case Rep. 2021 Jul 29;2021(7):rjab302
pubmed: 34336184
AME Case Rep. 2017 Dec 21;1:9
pubmed: 30263996
Chin J Cancer. 2014 Oct;33(10):492-500
pubmed: 25104281
Chemotherapy. 2021;66(3):82-86
pubmed: 34233328
Eur J Case Rep Intern Med. 2021 Aug 23;8(8):002763
pubmed: 34527624
BMC Womens Health. 2021 May 22;21(1):218
pubmed: 34022875
Ann Surg. 1931 Jan;93(1):250-68
pubmed: 17866470
ISRN Surg. 2013;2013:361469
pubmed: 23577269
Ann Surg Oncol. 2007 Oct;14(10):2961-70
pubmed: 17562113
Cancer. 1992 Jan 1;69(1):141-7
pubmed: 1309302
Ann N Y Acad Sci. 1964 Apr 2;114(2):922-36
pubmed: 4287066
Surg Case Rep. 2015 Dec;1(1):121
pubmed: 26943445
J Cancer Res Ther. 2018 Jul-Sep;14(5):1138-1141
pubmed: 30197364
World J Gastroenterol. 2006 Mar 14;12(10):1649-51
pubmed: 16570365
Int J Radiat Oncol Biol Phys. 2008 Feb 1;70(2):492-500
pubmed: 17931796
Ann Surg Oncol. 2012 Aug;19(8):2612-7
pubmed: 22476816
Acta Radiol Open. 2015 Jul 07;4(7):2058460115592061
pubmed: 26331090
Breast Cancer. 2020 Nov;27(6):1187-1190
pubmed: 32578005
BMC Cancer. 2019 Apr 23;19(1):372
pubmed: 31014268
Clin Transl Oncol. 2007 Apr;9(4):258-61
pubmed: 17462980
Medicine (Baltimore). 2015 Aug;94(33):e1312
pubmed: 26287414
Ann Med Surg (Lond). 2018 Nov 02;36:113-117
pubmed: 30455875
Rare Tumors. 2015 May 18;7(2):5684
pubmed: 26266007
J Clin Diagn Res. 2016 Apr;10(4):OD03-5
pubmed: 27190865